Top Tweets for #ashplenary
#ASH25 #ASHPlenary
#PARADIGM trial
Great work, congratulations to Dr. Fathi and colleagues! #AML #leusm
Summary:
The study met PE for EFS.
Higher ORR and CR in VEN+AZA gp
More pt received transplant in VEN+AZA gp
Better QOL


#ASH25 #ASHPlenary
Deciphering the dilemma: Intravenous (IV) iron use in iron deficiency anemia during acute infections
👉🏾 IV iron safe during infection and shown to improve outcome.
Dr. Haris Sohail 👏👏 Awesome job!

#ASH25 #ASHplenary
Outcomes of pregnancies in sickle cell patients treated with hydroxyurea : Findings from the escort-HU cohort studies: among 245 pregnancies with SCD. No maternal deaths or malformations noticed.

@SBenbarche @ASH_hematology @MaxStahlMD @MSKCancerCenter @DrCCutler @aamdsif @ASCO @ASHClinicalNews @ASTCT @IMFmyeloma @End_myeloma @RahulBanerjeeMD @HadidiSamer @MM_Hub @Eddie_Cliff @MyelomaTeacher @Myeloma_Society @MyelomaUK #ASH23 #ASHPlenary 6⃣
REACH trial showed ⬆️Hydroxyurea dose:
⬇️ VOC, acute chest, CVA
⬆️Hb, HbF
💡25-30mg/kg/day=optimized dose
🌟No significant added toxicity
♥️Hope for optimized sickle cell disease Tx in resource-limited settings like sub-Saharan Africa
https://t.co/jMwMQ0Ryws

@SBenbarche @ASH_hematology @MaxStahlMD @MSKCancerCenter @DrCCutler @aamdsif @ASCO @ASHClinicalNews @ASTCT @IMFmyeloma @End_myeloma @RahulBanerjeeMD @HadidiSamer @MM_Hub @Eddie_Cliff @MyelomaTeacher @Myeloma_Society @MyelomaUK #ASH23 #ASHPlenary 5⃣
Prenatal folate deficiency can program hematopoietic stem cell function during development, impacting self-renewal & engraftment potential in adulthood.
🩸Altered adult gene expression & metabolic profiles
🩸Mitochondrial dysfunction
https://t.co/8iSFPer6ye
@SBenbarche @ASH_hematology @MaxStahlMD @MSKCancerCenter @DrCCutler @aamdsif @ASCO @ASHClinicalNews @ASTCT #ASH23 #ASHPlenary 4⃣
IsKia Ph3 RCT: 1L KRd±Isatuximab in ASCT-eligible Pts with Multiple Myeloma
➕Isa ⬆️ 10^-6 MRD- rates after ASCT (67% vs 48% OR 2.29 p<0.001)
⬆️Heme AEs
❓Clinical significance of MRD- after ASCT (vs PFS/OS)
❓1L IsaKRd vs DRVd
https://t.co/V28zS1iryR

#ASH23 #ASHPlenary 2⃣
Small molecule "molecular glue degrader" (dWiz-2) targeted Wiz transcription factor allowing upregulation of HbF.
💡Mouse xenotransplant & macaque studies saw HbF increase to >20% by D28 on Tx
💡Emphasis on global accessibility
https://t.co/w3CBYx4pf9

#ASH23 #ASHPlenary 1⃣
AGAVE-201 safety/efficacy study of colony-stimulating factor 1 receptor (CSF-1R) inhibitor Axatilimab for previously Tx chronic GVHD.
💡55% Pt-reported clinically meaningful improvement
💡74% ORR
💡0.3mg/kg Q2W=🌟dose
⬆️FEV1 in some
https://t.co/THtX3whQAj

#ASH22 Outstanding teaching overview slide Dr @beth_psaila as #ASHPlenary introducer for #MPNSM | #JAK2 #CALR #MPL

#ASH22 Wow!! Awesome cover story #BreakingMab by Dr Natasha Szuber in yest very important #ASHPlenary well done by Dr @n_gangat & #ASHNewsDaily team !!! @ASH_hematology #ASHKudos 👏🏽

#ASH22 #MPNSM Dr Reis with a major discovery at #ASHPlenary final talk of session. Super important discovery in MPN field. Phase I study planned for 2023 !! @ASH_hematology

#ASH22 | #ASHPlenary Dr Reis Notable talk. Major discovery. First #CALR-mutant specific #mAb !!!!!@ASH_hematology

#ASH22 #ASHPlenary Wow !!! Discovery of a #CALR mutant specific #mAb for #MPNSM !!!! 👏🏽 @beth_psaila @ASH_hematology


#ASH22 #MPNSM Very much looking forward to this super important abstract in our MPN field soon at #ASHPlenary session !!! #CALR | cc: @mpndoc @KuykendallMd @bose_prithviraj @MDmasarova @LindaResar @KMirza @juliamaxson @NitinJainMD #leusm #MPNSM @ASH_hematology

#ASHPlenary 5⃣ by Bouzid et al on potential CHIP benefits🚨:
👉CHIP clones infiltrate the brain (⬆️fraction in microglial pool than circulating cells)
⬇️levels of CNS amyloid aggregates
🚨EXCLUDED patients with active dementia
⁉️protective effect from Alzheimer's Dz
#ASH21 #leusm

#ASH21 #ASHPlenary Conclusion slide #CHIP is associated with reduced risk of #AlzheimersDisease ; mutated cells can be found in brains of CHIP carriers. #microglia @jaiswalmdphd @pnatarajanmd #leusm #CHIPsm

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