Top Tweets for #bNabs
📰研究スポットライト | 併用療法で #HIV の生涯にわたるウイルスリザーバーの形成を防げるのでしょうか？
@NatureMicrobiol の新たな研究では、乳児マカクモデルを用いて、広域中和抗体（#bNAbs）、抗レトロウイルス療法（#ART）、#CCR5 阻害を組み合わせることで、HIVリザーバーの形成を抑制できる可能性が示されました。
🔬主な発見：
🔹感染72時間後に治療を開始した場合、bNAbsまたはART単独ではリザーバー形成を一貫して防ぐことができなかった
🔹CCR5阻害薬レロンリマブ（#leronlimab）により、リンパ組織および消化管組織へのウイルスリザーバーの播種を抑制
🔹3剤併用療法を受けた乳児マカクでは、治療中断後も複製可能なウイルスや潜伏ウイルスの証拠が認められなかった
🔹1年間の追跡期間中、検出可能なウイルスリバウンドはみられず、抗ウイルス免疫も獲得
💡HIVを複数の段階から標的化する――ウイルスを中和し、複製を抑制し、さらに細胞への侵入を阻止する――ことで、持続的なウイルスリザーバーの形成を防ぐ新たな戦略につながる可能性があります。
Combining #bNAbs, ART, and #CCR5 blockade showed promising results in an infant macaque model, highlighting the potential of early, multi-target intervention to prevent persistent #HIV infection.
#HIVResearch #Virology #Antiviral #Immunology
📰Research Spotlight | Can combination therapy prevent #HIV from establishing a lifelong reservoir?
A new @NatureMicrobiol study in an infant macaque model suggests that combining broadly neutralizing antibodies (#bNAbs), antiretroviral therapy (#ART), and #CCR5 blockade may limit HIV reservoir establishment.
🔬Key findings:
🔹bNAbs or ART alone were insufficient to consistently prevent reservoir establishment when treatment began 72 h after infection
🔹CCR5 blockade with leronlimab reduced viral reservoir seeding in lymphoid and gastrointestinal tissues
🔹The three-way combination showed no evidence of replicating or latent virus after treatment interruption in the treated infant macaques
🔹The animals remained without detectable viral rebound and developed antiviral immunity during the 1-year follow-up
💡Targeting HIV at multiple stages: neutralizing the virus, suppressing replication, and blocking cellular entry, could offer a strategy for preventing the establishment of the persistent viral reservoir.
#HIVResearch #Antiviral #Immunology #Virology #NeutralizingAntibody #DrugDiscovery #InfectiousDiseases #MedicinalChemistry
📰Research Spotlight | Can combination therapy prevent #HIV from establishing a lifelong reservoir?
A new @NatureMicrobiol study in an infant macaque model suggests that combining broadly neutralizing antibodies (#bNAbs), antiretroviral therapy (#ART), and #CCR5 blockade may limit HIV reservoir establishment.
🔬Key findings:
🔹bNAbs or ART alone were insufficient to consistently prevent reservoir establishment when treatment began 72 h after infection
🔹CCR5 blockade with leronlimab reduced viral reservoir seeding in lymphoid and gastrointestinal tissues
🔹The three-way combination showed no evidence of replicating or latent virus after treatment interruption in the treated infant macaques
🔹The animals remained without detectable viral rebound and developed antiviral immunity during the 1-year follow-up
💡Targeting HIV at multiple stages: neutralizing the virus, suppressing replication, and blocking cellular entry, could offer a strategy for preventing the establishment of the persistent viral reservoir.
#HIVResearch #Antiviral #Immunology #Virology #NeutralizingAntibody #DrugDiscovery #InfectiousDiseases #MedicinalChemistry
🚀Three #Nature studies show that strategically designed vaccines can prime rare B cells to produce broadly neutralizing antibodies (#bnAbs) against diverse #HIV strains.
#HIVVaccine #Vaccines #Immunology #bnAbs #VaccineResearch
🧬Research Spotlight | What if an #HIV vaccine could teach #Bcells to make broadly neutralizing antibodies?
Three studies in non-human primates demonstrate that rationally designed vaccines can prime B cells to produce potent antibodies against HIV.
🔸Engineered Env protein can bind to BCRs of the B-cell precursors
🔸Prime–boost strategies allow bnAbs maturation
🔸Vaccinated rhesus macaques produced antibodies capable of neutralizing diverse HIV strains
🔸Different approaches targeted conserved Env sites, including the V2 apex and V3-glycan epitopes
While protection against infection and long-term durability remain to be demonstrated, these findings mark an important step toward rationally designed HIV vaccines.
📰Read more @NatureNV : https://t.co/bUdo1M6hKR
#HIVVaccine #Vaccines #Immunology #bnAbs #BroadlyNeutralizingAntibodies
#CROI2026: Low levels of #bNAbs detected in rectal tissue up to 46 weeks post infusion:
https://t.co/rsWjnALHIb
Researchers say this shows the importance of including tissue sampling in cure-related #bNAb studies.
#HIV #HIVcure #HIVresearch #HIVtreatment #HIVscience
Great development in the currently hopeless #Ebola outbreak with #Bundibugyo strain. @WHO supported trial of Combination therapy with cocktail of two #bNAbs #MBP134 with #Remdesivir in #DRCongo.
Until now #Doctors watched and prayed, now look forward to treat
⏰ #AIDS2026 standard registration ends in 3 days!
Register by 7 May to lock in the final discounted fee.
We’re looking forward to sharing new science on funding impacts, prevention advances (#lenacapavir, #bNAbs, vaccines), #DoxyPEP & more.
🔗 Join us: https://t.co/qWNsRITEWc
11/21
HVTN 809 adds a SECOND parallel vaccine sequence targeting V2-Apex:
💉 DV201P (OPT4)
💉 DV202P (OPT4 shielded)
💉 DV203P (Q23)
💉 DV204P (BF1266)
TWO targets simultaneously = HIV has nowhere to hide. This is precision immunology. 🎯🎯 #HVTN809 #bNAbs @IAVI @IASociety
7/21
The hero molecules: bNAbs — Broadly Neutralizing Antibodies. HIV mutates constantly to escape your immune system. bNAbs attack parts of HIV that CANNOT mutate without the virus dying. Think of it as finding HIV's permanent weak spot. 🎯 #bNAbs #HIVImmunology #CureResearch
Today I attended @IASociety CPP HIV Vaccine Innovation Series: Part 1 — as a community advocate for HIV Vaccine R&D AND Cure Research, I'm breaking down everything I learned for PLHIVs in rural Uganda 🇺🇬 and the global community. Let's go. 👇 #HIVVaccine #HIVCure #bNAbs
2/21
Can "Super Soldiers" in our blood hold the key to an HIV cure?
📺 Watch the full breakdown here: https://t.co/v73O2oJ9jH
#HIVCure #bNAbs #GlobalHealth
@GileadSciences @TheDHVI @ViiVHC @HIVGlasgow @disclosurehiv @iasociety @HIVpxresearch
i-Base reports from #CROI2026. Main themes this year:
- ART pipeline
- #bNAbs in different settings
- #PrEP pipeline & #PEP
- Cure-related research
- GLP-1 agonists
- Political changes & impact of #HIVFundingCrisis
Our early summary – more to come later:
https://t.co/2HsmBpMXb6
A new Science #Immunology study in macaques identifies the V2 apex region of the #HIV envelope as the most common target for broadly neutralizing antibodies (#bNAbs) and finds that B cell priming is the bottleneck to bNAb induction. @rumihabib
https://t.co/8sL8p9W5zT
-HIV tedavi ve önleme araştırmaları alanında giderek daha sık duyulan bnAbs nedir?
-HIV pozitifler ve HIV negatifler için ne anlam ifade eder?
(*bnAbs: Geniş Nötralizan Antikor)
https://t.co/YYDmIFnjKE
herkes için #hivbilgisi
#hivhakkindahersey
#hivindogrusu
#beşittirb
#bnabs
🧬🌍 HIV Cure Trials 2025: Stem cell transplants, gene editing (CRISPR), & bNAbs are reshaping the future of HIV treatment.
🔗 More: https://t.co/ZlKnoq5nrx
#HIVCure #GlobalHealth #GeneTherapy #bNAbs #CRISPR #HIVResearch #MedicalBreakthroughs #EndHIV #HIVAwareness
RIO study Q&A: https://t.co/8WaFVyEBNd
- What is the #RIOstudy and how does it work?
- What are #bNAbs?
- What are the results and what do they mean?
- Has someone been cured of #HIV?
#CROI2025 #BHIVA25 #HIVcure #RIOtrial #HIVresearch #HIVtreatment #teropavimab #zinlirvimab
Exciting early @RIOtrial results at #CROI2025:
https://t.co/xZbx8MWrUG
New #bNABs so far successful in keeping viral load undetectable in some participants off #HIVtreatment.
Also the first time we’ve seen bNABs cause vaccine-like immune response.
#teropavimab #zinlirvimab
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