Top Tweets for #dapami
また工野先生に��付き合いいただき、
AHAの4演題を振りかえりました✨
全4回でもしよろしければ是非～
全体振り返りも直後のやつがどっかでアップされますのでそちらもよろしくお願いいたします🙇♂️
まずは #DAPAMI から
https://t.co/E9onndWBRt
#23AHA #aha23
３wほど遅れてしまいましたが、AHAについて水野先生 @atmizu とお話ししたDAPA-MIについてです。(収録はAHA会期終了後数日以内ですので内容の確認不足がありましたら��めんなさい）
AHAでお昼たべたので写真とればよかった,,,
アクセス権がございましたらぜひご覧ください
https://t.co/VdsejGCUvb
In pts w #AMI (no HF/DM), dapagliflozin improved composite outcomes via #cardiometabolic benefits
No ⬇️ in CV☠️ or #HF🏥, but event rates were v low (fraction of other #SGLT2i RCTs)
Nice e.g. of registry-based trial & protocol amendments to meet challenges #DapaMI
#AHA23
🎙️NEW #AHA23 #LBCT Discussion 💫Prof Stefan James, Prof Jonas Oldgren & host, Dr @hvanspall discuss the findings from the DAPA-MI
📽️Watch here👉 https://t.co/Qhxq5p39Mn
📊 Significant benefit of #dapagliflozin on cardiometabolic outcomes in non-diabetic patients with acute MI & impaired LV systolic function
#CardioTwitter
#AHA2023 #DAPAMI
#Dapagliflozin
♦️Post MI pts mean age 63 female 20%
♦️RRCT 70% pts from 🇬🇧 Well done @CardiacAudit
♦️Exp event 722, actual 102!
♦️DAPA did not reduce CV death/Hosp for heart failure or MI or stroke
♦️DAPA did show WIN due to ⬇️type 2 DM, NYHA class, weight⬇️
Presented at #AHA23:
“Dapagliflozin in Myocardial Infarction without Diabetes or Heart Failure” by Stefan James, MD, PhD, et al.: https://t.co/IkPXE5ixxB
@AHAScience #cardiology
#DAPAMI
🤔, seems a lower risk #heartattack group than expected, with primary composite outcome appearing to be driven by less diabetes, lower NYHA class & lower weight, with minimal magnitude of effects on death or #heartfailure hospitalisation.
(Low rates of death post MI).
#DAPAMI #AHA23 registry based pragmatic RCT(endpoint changed from CV💀 to cardio metabolic DM, BMI,AFib, NYHA) of
Low risk MI w/o DM with 2/3 patients with LV EF b/w 30-49% those randomized to Dapaflozin 10 mg had
⬇️incidence of DM
⬇️BMI
⬇️HF hospitalizations/CVD
Win ratio1.34 (hierarchy of clinical importance within the individual components) with lowest component 💀 & HFH
#DAPAMI #LBCT #AHA2023 #AHA23 @AHAMeetings @AHAScience
Dapagliflozin improves cardiometabolic outcomes compared w/ placebo in pts w/ AMI & impaired LV systolic function…
Underwhelming #DAPAMI trial. Positive WIN-ratio driven by weight loss (?), but nothing on hard endpoints...
No HF/DM/CKD. Very low event rate.
#DAPAMI #AHA23
Evaluating the effect of dapagliflozin on cardiometabolic outcomes in acute MI without DM or chronic HF
🫀significant benefit in cardiometabolic outcomes @CardioNerds
@kaulcsmc @ADAlthousePhD #DAPAMI (#AHA23) will also take an "expanded" WR approach for its PEP. While it will minimize ties, trial interpretability will be challenging
1. Death
2. HF hospitalization
3. Nonfatal MI
4. AF hospitalization
5. New T2D
6. NYHA class
7. Body weight ↓
https://t.co/XKjhNj71AN
Great line-up for #AHA2023 @AHAScience:
#SELECT #DAPAMI #CARDIASSBP #CARDIA1 #ARTERIA with RCT of great importance to BP and kidney doctors @hswapnil @kidneydoc101 @kidney_boy @valerie_luyckx
Happy to discuss the studies with @floriancustodis @StephanSchirme1 Prof. Werner
Delighted to be part of the #DapaMI #research @wwl_cardiology #recruitment @SamanthaLav2417 @nataliawadding #teamcardiology @WWLNHS ☺️🙌
Big achievement @Research_ULH for recruiting 66 patients (1 above the target) for #DAPAMI study. Well done to @clhyland_hewitt, Sarah Beck and all the research team involved with the study. Great team effort. Next round of drinks on Prof Lee @ULHT_News
Congratulations to the #DAPAMI team lead by PI Nigel Brown, Consultant Cardiologist, who have consented the 20th patient to the study today!
Great news for the team and thank you to the patients who are participating 😀
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