Top Tweets for #dronedarone
#Dronedarone exhibited significantly lower rates of CV hospitalization & VAs compared w/ #sotalol. These findings provide real-world evidence to support selection of the most appropriate first-line AAD for rhythm control in pts w/ #AFib. https://t.co/GaonCXJBrq #JACCCEP
an in-depth presentation on #Dronedarone, a key antiarrhythmic for managing atrial fibrillation. Understanding its indications, contraindications, and safety profile is critical before prescribing. Let’s ensure the right choice for the right patient. #Cardiology
#Lupin gets U.S. #FDA approval for ANDA of #Dronedarone tablets: Exchange filing
For the latest news and updates, visit: https://t.co/MVT9qbASgP
31d) However, in the post-ablation scenario, #dronedarone ⬇️#afib recurrence vs. sotalol & had fewer #CV events
🔓 https://t.co/0Uh6HaYj11
29a) What about #amiodarone vs. #dronedarone?
Here we have the #DYONISOS trial👇
https://t.co/CtEPGepPzs
25d) #Dronedarone was associated w/ ↘️CV events in 👥 w/ paroxysmal or persistent #AFib + #HF across the spectrum of #LVEF
However, powered trials are needed for confirmation
🔓 https://t.co/RK8L6jdvDc
25c) Here's a post-hoc analysis of #ATHENA, where it was analyzed the role of #dronedarone across the LVEF spectrum
🔓 https://t.co/RK8L6jdvDc, led by @cardiomet_ce faculty @mvaduganathan
24d) However, comedication w/ #digoxin may have ⬆️ mortality % in #PALLAS
#dronedarone–digoxin pharmacokinetic interaction (dronedarone ⬇️ renal excretion of digoxin)
https://t.co/hR5LfmDDBJ
24a) What is the available evidence on the use of #dronedarone in permanent #afib?
a) ⬆️% Restoring sinus rhythm
b) Heart rate control
c) a & b
d) Cardiovascular-safety concerns
23a) In which scenario should #dronedarone not be used?
a) Coronary heart disease #CHD
b) Decompensated #HeartFailure
c) #LV hypertrophy
d) #eGFR 35mL/min/1.73m2
19) Let’s talk about the evidence of #Dronedarone in #Afib.
#DAFNE study: dronedarone was more effective than placebo in maintaining SR (55%⬇️) after cardioversion at 800mg daily dose
🔓 https://t.co/lUa96cyVNk
14b) Unlike to #amiodarone, it doesn’t have iodine⚛️, which are related to toxicity
#Dronedarone also has a methyl-sulfonyl group that ⬇️ its lipophilicity & shortens its half-life to ⬇️ toxicity
🔓 https://t.co/N8WAPbGEXS
14a) #Dronedarone
The preferred 💊in #Afib 👥 w/ ischemic heart disease, LVEF>40% & stable or valvular heart disease
13d) However, the only class III 💊 recommended for long-term rhythm control in #Afib are #Dronedarone, #Sotalol & #Amiodarone
23) In #ATHENA, #dronedarone ⬇️ risk vs placebo of a primary outcome or hospitalization due to unexpected #CV events or death from any cause.
Also a significant ⬇️ in secondary outcomes with dronedarone, including #cardiovascular death & #stroke as single outcomes
22) Among pharmacological therapies, #dronedarone has been the most extensively studied #AAD in terms of rhythm control and adverse cardiovascular outcomes in nonpermanent AF, particularly in the #ATHENA trial
🔓 https://t.co/gPhz74Xx9Q
Limited data exist regarding the role of rhythm control (either by catheter ablation or AADs) in HFpEF
Post hoc analyses of #ATHENA suggest that #dronedarone appears to safely reduce CV events in patients with paroxysmal or persistent AF/AFL and HFpEF
#HeartFailure2023
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