Top Tweets for #hypercontractility
14a) The most common #sarcomeric mutations induce #hypercontractility of the myofilaments & induces #diastolic dysfunction. This requires ⬆️ energy from the #mitochondria & drains NADH towards ATP production, at the cost of antioxidative capacity.
9) This strong (or excessive) actin-myosin bound state leads not only to #hypercontractility, but also disordered relaxation (i.e. #diastole). See
👉🔓https://t.co/9CRKnPgXht
👉🔓https://t.co/mVQCKzXGRO
Marjoux @CHUdeLyon presents outcomes of randomized #Botox for treatment of #esophagus #hypercontractility and #spasm. Too bad: patients not injected still got better, but small study. #DDW18 #BrighamGIatDDW18
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