Top Tweets for #sarcomeric
14a) The most common #sarcomeric mutations induce #hypercontractility of the myofilaments & induces #diastolic dysfunction. This requires ⬆️ energy from the #mitochondria & drains NADH towards ATP production, at the cost of antioxidative capacity.
Disappointed to see the conservative approach to #genetic testing, recommending only the main #sarcomeric #genes. This ignores the recent evidence around FHOD3, CSRP3, TRIM63, ALPK3, etc. Also, phenocopies are not easily distinguishable and should be included from start, IMO.
@CircRes Feb 2nd Issue is Out! https://t.co/IiX6g6rOKd
Cover: Knockdown of the TF #SP1 leads to cardiomyocyte #hypertrophy of a #hiPSC-CM accompanied by intracellular #myofibrillar disarray (red) and #sarcomeric disorder (green); nuclei-blue.
35) It seems we have entered a new era of #HCM management with the development of #sarcomeric contractile inhibitors and approval of the first such agent, #mavacamten.
24d) Still, #genetic screening 🧬is key because even w/out symptoms, offspring members who inherit a #sarcomeric mutation must be followed up over time.
Signal-to-Noise Analysis Can Inform the Likelihood That Incidentally Identified Variants in #Sarcomeric Genes Are Associated with Pediatric #cardiomyopathy
#genetics #cardiogen
Kudos to @FMoussaviHarami and team @J_Powers_ @JD98119 @MichaelRegnier9 for pioneering work showing modulation of the tension time integral combining computational and experimental methods to mitigate the remodeling in the heart with #sarcomeric #mutation! @UWISCRM @UWMedicine
Unexplained HCM in adults: not just #sarcomeric, #fabry, #amyloid. Look for #redflags to find #noonan, screen the family to find #noonan & #sarcomeric
Combined PTPN11 and MYBPC3 Gene Mutations in an Adult Patient with Noonan Syndrome and Hypertrophic Cardiomyopathy, a rare association! https://t.co/sAFV0BxS31 @glimongelli
Moderated Poster Session 1A #Sarcomeric Function & #Contractility and 1B #Ion Channels and #Arrhythmias are under way. Support #EC investigators #BCVS20 @AHAMeetings @AHAScience @AHAScience
Program and Registration for #BCVS19 https://t.co/tdIumskTPo
#CardiacRemodeling #Sarcomeric #CardiovascularBiology #epigenetic #transcriptionalregulation #EpigeneticRegulation #GeneExpression #Cardiotwitter #basicresearch #CVresearch @aklfahed @ChristaTrex
Program and Registration for #BCVS19 https://t.co/XPLyTV6BTv
#Sarcomeric #CardiovascularBiology #epigenetic #transcriptionalregulation #EpigeneticRegulation #GeneExpression #Cardiotwitter #basicresearch #CVresearch
Start preparing #BCVS19 #abstractsubmission and awards close March 13th! https://t.co/hfgR0ey9oD #Sarcomeric #CardiovascularBiology #epigenetic #transcriptionalregulation #EpigeneticRegulation #GeneExpression #Cardiotwitter #basicresearch #Genomics #CellularModels #Genetics
Dr Minhaj Sirajuddin from the Centre for Cardiovascular Biology & Disease, inStem begins his talk on understanding the role of #sarcomeric #protein biology and its implications in #cardiomyopathy. - inStem Annual Review
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