Top Tweets for #ijbpr
The alkaloidal drug, quinine, is the first antimalarial drug isolated from #Cinchona_bark. The drug is still quite useful in the treatment of multidrug-resistant malaria. Chloroquine, a 4-aminoquinoline, was developed in the 1940s as a synthetic derivative from quinine.
#ijbpr

In the random selection, collection of all available #plants in the area, which is to be studied, is collected based only on visualization and observation without having knowledge and experience about the selected plants.
#Drug_discovery
#ijbpr
The #alpha_synuclein_protein aggregates in neuropathological diseases, such as Parkinson’s. The formation of these toxic clumps is characteristic of the illness, and they are associated with the related death of brain cells.
#ijbpr
While #gene_editing by CRISPR/Cas9 acts at the DNA level leading to a complete and irreversible depletion of the protein of interest (POI), RNAi induces reversible transcript degradation and, in turn, its reduction.
#ijbpr
Scientists working at Loughborough University, UK, and the University of Cordoba, Spain, have developed a new method for the rapid diagnosis of #poisoning in apparently drunk patients. The saliva-based test offers the potential to screen for poisons.
#ijbpr
Breath analysis in disease diagnostics is a promising research field, and the advances in instrumentation allows the accurate detection of #metabolites. But not only the health status of patients, but also the preservation status of museum artifacts could be monitored.
#ijbpr
The #bioanalytical chain describes the process of method development by biological samples includes sampling, sample preparation, separation, detection and evaluation of the results.
#ijbpr
The matrix-based #standard_curve should consist of a minimum of six standard points, excluding blanks, using single or replicate samples in case of bioanalytical method validation.
#ijbpr
The #bioreactor controller is the “brain” of the bioreactor platform. Its primary function is to monitor and control the critical process parameters within the vessel (eg, pH, culture temperature, dissolved oxygen tension, and media exchange).
#ijbpr
#Bioreactor is a apparatus for growing organisms (yeast, bacteria, or animal cells) under controlled conditions. Used in industrial processes to produce pharmaceuticals, vaccines, or antibodies.
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#Bioanalysis is a sub-discipline of analytical chemistry covering the quantitative measurement of drugs and its metabolites in biological systems like blood, plasma, serum, urine or tissue extracts.
#ijbpr
#Cell_lines are used for drug metabolism studies only in enzyme induced state and in cytotoxicity studies of drug and its metabolite. It is less popular due to de-differential cellular characteristic.
#ijbpr
#Human_microbiome research is one of the most relevant fields of innovation based on the large range of applications known and sectors currently or potentially involved. In fact, the US therapeutics market is meant to reach $6.9 billion by 2024.
#ijbpr
Potentially predictive #cancer_biomarkers include mutations on genes KRAS, p53, EGFR, erbB2 for colorectal, esophageal, liver, and pancreatic cancer; mutations of genes BRCA1 and BRCA2 for breast and ovarian cancer.
#ijbpr
#Biodegradable_polymers used in drug delivery systems are poly(lactic acid), poly(lactic-co-glycolic acid), polyanhydrides, poly(ortho esters), and poly(phosphoesters).In this, polymer matrix plays a major role. It releases the drug from the device to the skin.
#ijbpr
AMPs usually form a helix structure, act through the #bacterial_cell_membrane, form ion channels or pores on the microbial membranes, leading to membrane permeability and causing leakage of intracellular substances to result in bacterial death.
#ijbpr
#Antimicrobial_peptides and proteins are class of naturally occurring molecules that are produced as a first line of defense by all multicellular organisms. These proteins can have broad activity to directly kill bacteria, yeasts, fungi, viruses and even cancer cells.
#ijbpr
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