Top Tweets for #imerge
This morning at #ASH25, @Dr_AmerZeidan shares an analysis of the #imerge trial for patients with lower-risk myelodysplastic syndromes. #LRMDS
https://t.co/SYkq5KUadU
@SmilowCancer @YaleHemOnc @YaleHematology @ASH_hematology
ICYMI from #Heme Today's coverage of #ASH24 --
Pooled data analysis from the #IMerge trial found #imetelstat produces benefit in #myelodysplasticsyndromes independently of any prior #luspatercept, #lenalidomide, or #hypomethylatingagent tx. #MDS
https://t.co/0yrQPgTo7r
#Heme Today is covering #ASH24 !!!
Coming up for presentation - #IMerge data analysis findings:
#Imetelstat benefit in #myelodysplasticsyndromes is independent of prior #luspatercept, #lenalidomide, or #hypomethylatingagent tx.
#MDS
https://t.co/0yrQPgTo7r
ICYMI in #myelodysplasticsyndrome news -- from #Heme Today's coverage of #EHA2024 --
New analysis findings from the #IMerge trial underscore the benefits from a #telomeraseinhibitor in pts with transfusion-dependent #MDS
https://t.co/QajHeifzbA
From #Heme Today coverage of #EHA2024 -- New analysis of the #IMerge trial support the study's initial findings of benefits from a #telomeraseinhibitor in transfusion-dependent #myelodysplasticsyndrome.
#MDS
https://t.co/QajHeifzbA
#Imetelstat now ⏰ approved 🎉 in #MDS #iMerge
👉 first in class for LR-MDS Rx
👉 consider in 2nd line esp for TD-MDS
👉 watch 👀 for ⬇️ANC PLT as AE
👉 IV 💉 q 28 days
@TheLancet #MDSsm
https://t.co/U0Vz4TI6cS
#Imetelstat now @US_FDA approved for low or intermediate-1 risk transfusion dependent MDS based off #IMerge by @Dr_AmerZeidan:
- 8wk rate of TI higher with imetelstat
- Neutropenia & Thrombocytopenia AEs
#HemeTwitter #OncTwitter @OncoAlert #Hematology
A year ago exactly I stood on the podium at #ASCO23 to present the primary results of the #IMERGE randomized phase 3 study showing efficacy of imetelstat in lower risk #MDSsm & could barely hide my excitement as I have anticipated the potential of this drug to help many patients
Few things in a clinical investigator’s career matter as much as touching the lives of many patients he will never see by getting a good drug approved! FDA approves imetelstat for lower risk myelodysplastic syndromes #MDSsm w transfusion-dependent anemia https://t.co/CgTaLGDGlb
So satisfying to watch live the #ODAC meeting (at 4 AM Kyoto 🇯🇵 time where I am at #MDSsm meeting) & see vast majority of panel recognize the benefits over risks of #imetelstat based on our pivotal #IMerge trial, & look forward to having the drug approved for our patients!
28c) The correct answer is a. As in the plot above, mutational data ➡️a ⬇️of the myelodysplastic clones with #imetelstat exposure, suggesting the drug has disease-modifying activity.
See also the full #IMerge ms in @TheLancet at https://t.co/RpVkW3b1lD.
25a) Nonetheless, #imetelstat represents another option for our patients with #LR_MDS.
What was the median increase in Hgb with imetelstat seen in #IMerge?
20) #IMerge studied the drug #imetelstat. #Telomerase activity looks to be higher in #MDS cells vs normal counterparts. Imetelstat is a potent, 1st in class telomerase inhibitor. Study rationale: imetelstat targets MDS cells & will improve #cytopenias/ ⬇️transfusion burden.
Full results of the #IMerge phase 3 study of Imetelstat in patients with lower-risk myelodysplastic syndromes #MDSsm now published in the @TheLancet Hope this results in approval of a new effective drug for our patients @ic_MDS https://t.co/mtcXk2jTIL
24) @Dr_AmerZeidanof @Yale, one of our expert @onc_ce faculty, led the Ph 3 #IMerge study of #imetelstat, from which data were also presented at #ASCO2023.
🔓 https://t.co/iGn3ULJ169
15) What about #LR_MDS that is relapsed or refractory to erythropoiesis stimulating agents (ESAs)—so beyond 1L options? There’s breaking news there too, also from #ASCO23, courtesy of @Dr_AmerZeidan of @Yale and the Ph 3 #IMerge study of #imetelstat.
🔓 https://t.co/iGn3ULJ169
4) It has been an eventful early summer in 🌎 of lower risk #MDSsm. New data at #EHA23 #EHA2023 #ASCO23 #ASCO2023 with practice-changing #COMMANDS & #IMerge trials! Could there be 🆕 first-line therapy (#Luspatercept) & a new second-line (#imetelstat) approach?
A reflection from #EHA2023 on our progress in #MDSsm-I met several people who pointed out to me that they attended my presentation of the positive phase 3 #IMerge study of #imetelstat in #ASCO23 & that my opening statement during the presentation (when I mentioned they are witnessing history by attending back-to-back presentation of two positive randomized phase 3 studies in #MDSsm -with #COMMANDS trial of #luspatercept being also presented in that session-while we had less than 5 positive randomized phase 3 studies in the last 25 years in MDS) still resonates with them given the many positive randomized trials in other blood cancers like #AMLsm & #MMsm that are presented in regular basis. This is a testament to the progress we are witnessing in the field & hopefully many more positive phase 3 trials for #MDSsm which will hopefully help our patients live better and longer lives..
A great moment of progress (& a personal pride for involvement) in lower risk #MDSsm with #COMMANDS trial showing a drug (luspatercept) for first time beating ESA for anemia. Results shown in plenary session in #EHA23 & #EHA2023 & concurrent publication in @TheLancet @YaleCancer
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