Top Tweets for #kn522
Here is the table for 7 studies we touched on during our Breats Cancer highlights discussion from #ASCO26 w/ @hoperugo
✅ #OPTIMA
✅ #lidERA
✅ #VIKTORIA1
✅ #KN522
✅ #ASCENT03 & #ASCENT04
✅ #TropionBreast02
#bcsm #OncTwitter #MedTwitter @OncoAlert @OncUpdates
Breast Cancer Highlights from #ASCO26 w/ @hoperugo
✅ #OPTIMA
✅ #lidERA
✅ #VIKTORIA1
✅ #KN522
✅ #ASCENT03 & #ASCENT04
✅ #TropionBreast02
Full 🗣️
⭐️ “Oncology Brothers” podcast
⭐️ https://t.co/S85jcN6WRu
#OncTwitter #MedTwitter #bcsm @OncUpdates
Breast Cancer Highlights from #ASCO26 w/ @hoperugo
✅ #OPTIMA
✅ #lidERA
✅ #VIKTORIA1
✅ #KN522
✅ #ASCENT03 & #ASCENT04
✅ #TropionBreast02
Full 🗣️
⭐️ “Oncology Brothers” podcast
⭐️ https://t.co/S85jcN6WRu
#OncTwitter #MedTwitter #bcsm @OncUpdates
🔥 @OncBrothers #ASCO26 Day 2 Recap:
#KN522
#OPTIMA
#lidERA
#SENOMAC
#TALAPRO3
#TRITON
What are some of your key takeaways from Day 2🤔
#OncTwitter @ASCO #MedTwitter #MedX #Oncology #HemOnc @ASCOPost
Day 2 #ASCO26 highlights:
Breast Cancer:
1. #KN522 (update): IO + Chemo TNBC
2. #OPTIMA: Adj Chemo HR+
3. #lidERA: Adj SERD HR+
4. #SENOMAC: ALND omission
Prostate Ca
5. #TALAPRO3: PARPi
NSCLC:
6. #TRITON: Dual ICI mNSCLC
#OncTwitter @ASCO @OncoAlert
1/7
Day 2 #ASCO26 highlights:
Breast Cancer:
1. #KN522 (update): IO + Chemo TNBC
2. #OPTIMA: Adj Chemo HR+
3. #lidERA: Adj SERD HR+
4. #SENOMAC: ALND omission
Prostate Ca
5. #TALAPRO3: PARPi
NSCLC:
6. #TRITON: Dual ICI mNSCLC
#OncTwitter @ASCO @OncoAlert
1/7
@SuyogCancer @batraatulonc @myESMO @stolaney1 @dr_yakupergun @OncoAlert This was also a really ⬆️ risk subset of TNBC in a country with less access - many had very large tumors & nodal burden.
Compared to #KN522...gosh, how impressive.
Reality is it wouldn't change a thing in 🇺🇸 for cost, system seems kind of broken, no?
#ESMO25 #ESMOAmbassadors
One of the most searched trials on our CLIN platform is KEYNOTE-522!
A huge shout out to the experts driving the conversation:
@lab_kok, @stolaney1, @DrHBurstein, @drsarahsam, @ErikaHamilton9, @OncBrothers, @dr_yakupergun
https://t.co/5GK6PvZ0az
#BreastCancer #oncology @Larvol
#SABCS24 Part1: Highlights w/ @laura_huppert
✅ #INSEMA
✅ #KN522
✅ #OlympiA
Full 📢:
⭐️ https://t.co/PzSPh9KsBz
⭐️ https://t.co/A2lFpwXbJR
⭐️Also on “Oncology Brothers” podcast
⭐️Part 2 & 3 w/ @jamecancerdocan & @stolaney1 to follow
#OncTwitter #bcsm @TargetedOnc
Thank you Dr. Roberto Salgado for the masterclass on #TILs at @SABCSSanAntonio.
Key takeaway:
“TILs are for TNBC (and HER2) what grade is for luminal disease.”
#bcsm #SABCS24 #TILs #KN522 @TILsWorkGroup
4. #KN522: current SoC PeriOp IO + neoAdj Chemo and then Adj IO for high risk TNBC.
- This remains the current standard of care. As of now, there are no specific markers available in clinical practice to predict IO benefit in these patients.
Update on KN522 study.
Extensive biomarker analysis of subgroups of TNBC shows that…all benefit from pembro. So far no selective marker for who does or does not need chemo +IO
#SABCS24 Day 1 Highlights #CommunityOnc:
1. @FDAOncology Reviews recent approvals: #Ribociclib & #Inavolisib
2. #PADMA: HR+ ET + CDK4/6i vs Chemo 1L
3. #DB06: HR+ TDXd
4. #KN522: biomarker analysis
@SABCSSanAntonio @AACR #bcsm #OncTwitter
1/5
< 2 weeks to #SABCS24, here is a📝 of 🔑abstracts from #CommunityOncologists perspective.
- #EUROPA
- #EMBER3
- #SONIA
- #PADMA
- #TOUCH
- #DB012
- #OlympiA
- #KN522
- #REDUSE
#MedEd #bcsm #OncTwitter @UTHealthSAMDA #breastcancer @AACR @SABCSSanAntonio #MedTwitter
Our study on real-world irAEs #KN522
•233 pts: 34% all grade, 10% grade ≥ 3 irAE
•1 in 4 irAEs hospitalized
•15% adrenal insufficiency
•10% colitis (2 deaths)
•67% unresolved
Predictive biomarkers crucial.Many unmet survivorship needs
@CarlosHBarcenas @athira_jayan14 #bcsm
Real-World Immune-Related Adverse Events in Patients
With Early Triple-Negative #BreastCancer Who Received Pembrolizumab: https://t.co/eaJIKsgeSU @CarlosHBarcenas #bcsm
Breast Ca Highlights from #ESMO24 w/ @PTarantinoMD
- #NATALEE
- #KN522
- #DestinyBreast12
Full Int:
- https://t.co/1ytCOTu6zc
- https://t.co/SU8PEdhysW
- Also on the “Oncology Brothers” podcast
#bcsm #OncTwitter #MedTwitter @TargetedOnc @myESMO
Day 3 #ESMO24 highlights:
1. #KN522: Update TNBC
2. #NIAGARA: resectable MIBC @tompowles1 @PGrivasMDPhD
3. #CONTACT02: Update mCRPC @neerajaiims
4. #NICHE2: dMMR Colon Ca @MyriamChalabi
1/5
#OncTwitter @myESMO @OncoAlert #bcsm #gism #MedTwitter
Overall survival (after 75.1 mons follow-up) showed improvement w/ addition of pembro w/HR 0.66, absolute benefit at 5 years of 4.9% for patients with early stage TNBC.
#KN522 #ESMO22 @myESMO @OncoAlert
#KN522 OS data 5 yrs after the initial pCR presentation
75 months of f/u for chemo +/ pembro I stage II and III #TNBC
🌟 EFS is stable from before with 9% improvement w/ pembro
👏 OS improved by 5% (81.7-> 86.6%)
#ESMO24
#ESMOAmbassadors
~1 week to #ESMO24, here is a📝 of 🔑abstracts for general onc that could change/reinforce our SoC!
- #NIAGARA
- #KN522
- #NATALEE
- #DB12
- #MARIPOSA2
- #KRYSTAL12
- #NICHE2
- #SAKK41
- #POD1UM
- #KN811
#BCSM #GISM #LCSM #MedTwitter #GUSM #OncTwitter @myESMO @OncoAlert
SABCS23 Day 4 Highlights by @OncBrothers
@IlanaSchlam
#BreastCancer #Cancer #Fulvestrant #INAVO120 #Inavolisib #KN522 #OncoDaily #Oncology #OncologyBrothers #Palbociclib #Ribociclib #SABCS23
https://t.co/o1szfulxuW
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