Top Tweets for #mHTT
As reported in the Journal of @AmerChemSociety, researchers demonstrated that a proteolysis-targeting chimera (#PROTAC) penetrates the brain to preferentially degrade mutant huntingtin (#mHTT) aggregates in #HuntingtonDisease (HD) mice.
Read here: https://t.co/w5LouSdiTP
Ecco un'altra buona notizia sul fronte delle #sperimentazioni grazie ai dati positivi diffusi da @WaveLifeSci sullo studio #SelectHD, che ha mostrato la capacità di ridurre solo la proteina #huntingtina mutata #mHTT, lasciando intatta quella sana.
https://t.co/IblDa0JkKU
For those across the Diaspora who've been asking me how they can get involved in the archaeology work happening in Greenwood/Black Wall Street...Now's your chance!
https://t.co/Zfpf3ic1BA
@AITC_DC @InsideNatGeo @NatGeoEducation
#MHTT #GreenwoodArchaeology
New #bioinfonotes about Huntington’s Disease has been published !
#biology #science #huntington #mutation #pathogenesis #disease #mHTT #autosomal #huntingtin #biologynotes
$SGMO + #CHDI Foundation granted Patent 11110154
Froelich ,Sept 7, 2021
Methods and compositions for treating #HD
Disclosed herein are methods and compositions for #treating or #preventing #Huntington's Disease
reduces #mHtt expression by at least 85%
https://t.co/BKsZoea8sY
Do increased Rab8 levels protect against mutant HTT toxicity? See a recent #JHD article investigating it: https://t.co/FrlbAVEix1
#JournalofHuntingtonsDisease #Huntingtonsdisease #HD #HDResearch #RABGTPase #mhtt #Drosophila #HDmodel
US patent application filed today which could be the milestone trigger for transitioning $SGMO program to $PFE.
#GeneRegulation #mHTT
$TAK got #mHTT program from acquisition but most of their commentary was about $WAVE collab and $DNLI collab signed in C18. Last R&D day presentation began to highlight $SGMO ZFP-TF which is based again on Ojala delivery work
4/
CONCISE REVIEW
Prion‐like mechanisms in neurodegenerative disease: Implications for Huntington's disease therapy
#Huntingtons #HD #mHTT #prion #stemcells #transplantation
https://t.co/iub1e7GD9S
Good to see $TAK $SGMO is working to design clinical trial for #mHTT repression using #ZFP_TF
TAK-686 #GeneRegulation
https://t.co/NLt0vFW0JY
For anyone who might be interested, my thesis is now available online #openaccess 🤓 Not expecting many reads😅
https://t.co/zs143jUZ9x
#Huntingtonsdisease #hd #biofluid #biomarkers #neurodegenerativedisease #neurofilament #nflight #htt #mhtt #mutanthuntingtin
It is finally online! This #preprint is literally 5 years of blood, CSF and tears (many mine ha)! It has been a labour of love that is an important addition to our knowledge of #Huntingtonsdisease #biomarkers #nfl #neurofilamentlight #mhtt
Nature2019トップ10論文中バイオメディカルは：変異huntingtin（#mHTT）タンパクのオートファジー清掃を可能にする #HTT LC3リンカー化合物の同定；CRISPRの#Prime editing手法の開発；驚きの「#父親由来mtDNA」の報告。
https://t.co/VJgrPURHbj
" กลัวว่าสักวันหนึ่ง...
คุณจะไปเงี่ยนใส่ใคร ใครที่ไม่ใช่ฉัน "
😆😆😆😆 #mhtt💕
#แคปชั่นจังไร #แคปชั่นเด็ด #แคปชั่นกวน #แคปชั่นโดนๆ
#Huntington #thérapie génique: correction de la maladie chez la #souris en bloquant le gène muté #mHTT https://t.co/IakDAI65PE
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