Top Tweets for #msih
@dhemit_is_back Rumah #Dinas itu artinya fasilitas utk para TNI yg #msih brDinas .. jk Rumah Dinas msih #dikangkangi trus oleh yg sdh #Tdak lg brDinas mk .. jlas hal tsb #mnZolimi para TNI yg skrg #sdg brDinas tsb !!
Hrusnya .. jk kualitas Otaknya dipake #sdikit sj .. tentu dah #paham nalar_nya
ESMO review : Must read
🔬 MSI-H ≠ colorectal only.
🚀 Immunotherapy is the backbone across non-CRC GI cancers—early, durable, and often chemo-free.
⚠️ Surgery & chemo? Be selective.
#MSIH #GIOnc #Immunotherapy @OncBrothers @OncoAlert

COMMIT Trial | dMMR/MSI-H mCRC
1L atezolizumab + mFOLFOX6 + bevacizumab > atezo alone
📈 PFS: ~24.9 vs ~13.7 mo
HR 0.53 (95% CI 0.38–0.75)
Toxicity ↑ but manageable
Deeper & more durable control.
#GIOnc #MSIH #Immunotherapy #MedTwitter

• MSI-H CRC isn’t uniform
• Early-onset → Lynch-like biology (MSH2/MSH6, KRAS/APC/PI3K, CMS3/4) + better IO responses
• Late-onset → Sporadic (MLH1-methylation/BRAF) + less IO benefit
• Etiology matters
#Oncology #CRC #MSIH #Immunotherapy #PrecisionOncology

JMIR Formative Res: A Machine Learning–Based Scoring System to Identify High Immunoactivity Microsatellite Stability Tumors by Quantifying Similarity to Microsatellite Instability-High Tumors… https://t.co/GXgihLCq3O #MachineLearning #ColorectalCancer #MSS #MSIH #Immunotherapy

FDA-approved The MMR IHC Panel pharmDx (Dako Omnis) as a companion diagnostic for identifying MSI-H/dMMR CRC patients eligible for treatment with:
Nivolumab – Monotherapy
Nivolumab + Ipilimumab – Combination therapy
#FDAApproval #CRC #MSIH #dMMR #Nivolumab #Ipilimumab #diagnosis

@YJanjigianMD #AACR2025 CtDNA Status to direct adjIO for MMRd tumors: Great talk by Dr @YJanjigianMD! #MSIH #Immunotherapy #CRCSMVery nice study and much needed for this patient population. #CRCSM
Outcomes in CtDNA (+) pts & ctDNA clearance seen.
Very interesting results

#AACR2025 CtDNA Status to direct adjIO for MMRd tumors: Great talk by Dr @YJanjigianMD! #MSIH #Immunotherapy #CRCSM
Very nice study and much needed for this patient population.
#CRCSM

#AACR2025 CtDNA Status to direct adjIO for MMRd tumors: Great talk by Dr @YJanjigianMD!
#MSIH #Immunotherapy #CRCSM

FDA approves nivolumab + ipilimumab for unresectable/metastatic MSI-H/dMMR colorectal cancer in adults & kids.
PFS not reached vs 5.8 mo with chemo (HR 0.21; P<.0001).
ORR: 71% vs 58%.
A game changer for this tough population.
#oncology #CRC #MSIH #dMMR #immunotherapy

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