Top Tweets for #phart2
2nd RCT showing #hypoRT 🟰 conv RT for high risk #ProstateCa
@DrPatCheung #PHART2 RCT (PA @r_glicksman) was 1st: https://t.co/fIPFJNHBpO
Now Q is the role of UHRT. Many trials accruing:
@CDNCancerTrials #PR24
@VedangMurthy #PRIME
@DrSuneil_PCa #PACE-NODES
@NRGonc #GU013
Hypofractionated Dose Escalation Radiotherapy for High-risk Prostate Cancer: The Survival Analysis of the Prostate … https://t.co/K7Nc3Zpkis
I was hoping for efficacy results (or at least PSARR @4y)…
@niazi_Dr7 when do plan to cut those data?
@DrCorreaRO and @DrPatCheung have analyzed @Sunnybrook #PHART2 RCT (same design, n=178). mFU 64 mo - efficacy and toxicity will be reported.
Stay tuned!
🗣️ Ph III trial HF 68Gy/25 vs standard fractionated (SF) 76Gy/38 HR #prostatecancer both arms pelvic RT+ADT
▶️329👥: 164 HF vs 164 SF
🔑Results
👉⬇️acute GI in HF (p=0.016), but not sig at 8 weeks
👉 NO# acute GU
👉At 24 mo: 🟰 GI tox but ⬇️ GU HF
👉⬇️ G3 tox/NOG4
#radonc
We plan to compare #SATURN and #5STAR (#SBRT to pelvis and prostate) with moderate hypofx (25fx to pelvis/prostate) and conventional RT (latter two as part of @DrPatCheung #PHART2 RCT)
@jfcdrr @EvanThomas84 @the_RSS @marslain SBRT is an acceptable option for HR and VHR per NCCN. For high risk, it says “nodal radiation should be considered” but does not comment on fractionation. @DrAndrewLoblaw @VedangMurthy @DrDarrenPoon Good published data for 25/5
@VedangMurthy @AmarUKishan @achoud72 @Sushilberiwal @RTendulkarMD @docpriyamvada @indranilsays @DrSrinivas_C @AbhiG_RadOnc @RadOncTMC @Sunnybrook we allowed 25/5 concomitantly with 40/5 (#SATURN technique) when Covid-19 hit. Probably have treated about 200 pts weekly or more commonly EOD.
Used about as often than our moderate hypofx protocol #PHART2 developed by @DrPatCheung
Expertly written by @r_glicksman ! Looking forward to seeing PHART2 RCT results and a comparison b/w #PHART2 and #SATURN
Long term (>10y) data from pHART2- moderately hypofrac prostate boost with ENI +ADT for high risk disease. 10y BCF 33%, DM 16%, OS 76%. 5y toxicity and patient reported QoL. PI: P Cheung. @DrAndrewLoblaw @gerard_morton @dr_vesi @DrStanLiu @Sunnybrook https://t.co/8IwnVXToBS
@merino_tomas @DrAndrewLoblaw @PCaParker @nickva1 @_ShankarSiva @DrewMoghanaki @DrSuneil_PCa @AmarUKishan @PBlanchardMD We do 65 in 25 as a SIB.
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