Top Tweets for #rorgt
@BowTiedBiotech I would not expect Th17 psoriasis flare for $CRVS as ITKi w/ #soquelitinib stops Th17 cells. ITKi effectively blocks #GATA3 preventing #Th2 AND #RORgt in #Th17 potentially provide patient benefit across the entire AtD to psoriasis spectrum.
https://t.co/WSSfQr0SRb
Reasons $CRVS novel oral #ITK inhibitor #soquelitinib may work better than #Dupixent in #atopicdermatitis.
1. ⬇️ #Th2+#ILC2 cells AND ⬇️ #Th17
2. Reduces more cytokines in both Th2 + Th17 pathways #IL4 #IL5 #IL13 #IL31 #IL17 #IL21 #IL22, benefit across entire Th2/AtD <––> Th17/PSO spectrum
3. More cytokines = more patients benefit from more severe AtD to refractory dupi/biologic cases
4. ⬆️ T-reg cells
Over long-term, #Dupixent benefit in AtD may wane:
1. U-shaped response: #IL4 #IL5 #IL13 fall quicky, but then rise back or above original pre-treatment levels
2. Blocking Th2 IL-4Ra can lead to compensatory Type 3 inflammatory response increasing #Th17/#IL17 as seen in 4 of 10 patients, leading to #psoriasis #rosacea
https://t.co/vZLZjQjsob
Casper Ohnmacht and colleagues decipher how intestinal #RORgt Treg subsets are determined:
https://t.co/RW6fVEMrxS
Researchers discover new drug target for inflammatory bowel disease
Learn more: https://t.co/zLVfY1V7yr
@CellReports @utswcancer @UTSWNews
#IBD #Crohnsdisease #psoriasis #RORgt #Diarrhea #meded #eMednews
November @TrendsImmuno #astrocyte #IL3, #lymphatics, cytosolic bacteria, #cGAS, #mTOR #gasdermin, #Bcell memory, #ADAR1 #antiviral, #SARSCoV2, #Checkpoint #immunity, #cancer-immunity #metabolism, #Tcell activation, #IFN #mucosa, #RORgt #IL17, #inflammation https://t.co/uBGvZr0m7v
Today, we enrolled the first #psoriasis patient in Part C of our ongoing phase 1 clinical trial of #IMU935, a highly potent and selective inverse agonist of the transcription factor ROR��t.
More details: https://t.co/uhJNAhQwjs
#RORg #RORgt $IMUX
#WorldPsoriasisDay: Our #IMU935 program, a highly potent and selective inverse agonist of #RORgt, is currently in phase 1 trials. We plan to extend these in H1 2020 to assess safety and mechanism-related biomarkers in #psoriasis patients. https://t.co/ptu2QajSK7 #letsgetconnected
Today, we announced dosing of the first healthy volunteer in our phase 1 clinical program of #IMU935, a potentially best-in-class #RORgt inverse agonist. We are very proud that our second development program has entered the clinical stage! https://t.co/U7TQU7intq $IMUX #psoriasis
A closer look at #RORgt function using small molecule #Inhibitors | JinfangZhu @NIH @TrendsImmuno https://t.co/sUlAUSrQxi
A closer look at #RORgt function using small molecule #Inhibitors | JinfangZhu @NIH @TrendsImmuno https://t.co/sUlAUSrQxi
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