Top Tweets for #IL21
Reasons $CRVS novel oral #ITK inhibitor #soquelitinib may work better than #Dupixent in #atopicdermatitis.
1. ⬇️ #Th2+#ILC2 cells AND ⬇️ #Th17
2. Reduces more cytokines in both Th2 + Th17 pathways #IL4 #IL5 #IL13 #IL31 #IL17 #IL21 #IL22, benefit across entire Th2/AtD <––> Th17/PSO spectrum
3. More cytokines = more patients benefit from more severe AtD to refractory dupi/biologic cases
4. ⬆️ T-reg cells
Over long-term, #Dupixent benefit in AtD may wane:
1. U-shaped response: #IL4 #IL5 #IL13 fall quicky, but then rise back or above original pre-treatment levels
2. Blocking Th2 IL-4Ra can lead to compensatory Type 3 inflammatory response increasing #Th17/#IL17 as seen in 4 of 10 patients, leading to #psoriasis #rosacea
https://t.co/vZLZjQjsob
From 2021, good summary of therapeutic landscape (oral + biologic) for #psoriasis and #atopicdermatitis
Independently targeting #Th2 or #Th17 pathway can lead to shift in balance, resulting in induction of antagonistic disease (i.e., treating psoriasis can unmask/cause atopic dermatitis)
- $CRVS oral ITK inhibitor #soquelitinib unique MOA makes it ideally suited to address this spectrum and overlap of disease between Pso and AtD.
- Table shows soquelitinib has the ability to affect multiple pathways at once blurring the distinction between PsO and AtD treatments and may present the opportunity for a single oral drug to treat both diseases, allowing for disease control in mixed cases of both.
https://t.co/IwgYzSZki7
Featured today by @MSKLibrary: IL-21 shapes the B cell response in a context-dependent manner
#IL21 #BCellResponse #Immunology #Cytokines #ImmuneRegulation #BiomedicalResearch
@yjkim_93 @SimonGrassmann @SunLab_Official @chaudhuj @SDownsCanner
https://t.co/f4mJeyVDeW
NK cells expressing interleukin-21 show promising antitumor activity in glioblastoma cells #IL21 #MECFS #LongCovid
https://t.co/gjZNKEULPn
I am so proud of my friend and colleague @Mayrashanley for her amazing paper just out in @Cancer_Cell! All your hard work and dedication paid off Mayra 🥳 such an impactful work for the #NK cell field! Congratulations!! @lab_rezvani @MDAndersonNews #IL21 #cytokine #celltherapy
Delighted to share our latest research published in @Cancer_Cell Cell. Our study shows that intratumoral administration of IL-21 engineered NK cells resulted in strong and sustained antitumor activity against glioblastoma compared to IL-15 NK cells, which carried significant toxicity when administered intracranially in multiple orthotopic mouse models. We also discovered the critical role of the CEBP family of transcription factors, particularly CEBPD, in maintaining the potency of IL-21 NK cells. Congratulations to @Mayrashanley and many thanks to our collaborators. @FrederickLangMD, Juan Fueyo MD, Cande Gomez-Manzano MD, @abhinavjain_phd, @kchenken. Looking forward to taking this to the clinic! https://t.co/0yfrnGG3XF #CancerResearch #Glioblastoma #NK #immunotherapy #cytokines #IL21
#CuttingEdge from Jason S. Weinstein @Rutgers_NJMS & Joe Craft @YaleMed | unique environmental signals underlie the tissue-specific development of age-associated #Bcells #ReadTheJI #immunology #interferon #IL21 https://t.co/7CnrBhDGDB
How does #IL21 affect inflammatory cells, especially T cells in plaques in #atherosclerosis?
Roy Snijckers shows IL21 blocking attenuated #atherosclerosis .
@LACDR #DAS2023 @UniLeidenNews
7) Profs. @sautesfridm & Hadyn Kissick chair a Fantastic session on tertiary #lymphoid #Structures #TLS /PhD student @LucasBlch #CD62P #CD62L #SITC2022 #SITC22 B Cell Zone/ #Mab #FinishCancer #IL21 #CXCL13 #MECA79 #stem_Like #HEV
6) Profs. @sautesfridm & Hadyn Kissick chair a Fantastic session on tertiary #lymphoid #Structures #TLS /PhD student @LucasBlch #CD62P #CD62L #SITC2022 #SITC22 B Cell Zone/ #Mab #FinishCancer #IL21 #CXCL13 #MECA79 #stem_Like #HEV
5) Profs. @sautesfridm & Hadyn Kissick chair a Fantastic session on tertiary #lymphoid #Structures #TLS /Dr José Conejo-Garcia 💥AB FROM TLS B CELLS ABROGATE TUMOR GROWTH 💥 #SITC2022 #SITC22 B Cell Zone/ #Mab #FinishCancer #IL21 #CXCL13 #OvarianCancer
4) Profs. @sautesfridm & Hadyn Kissick chair a Fantastic session on tertiary #lymphoid #Structures #TLS /Dr José Conejo-Garcia 💥AB FROM TLS B CELLS ABROGATE TUMOR GROWTH 💥 #SITC2022 #SITC22 B Cell Zone/ #Mab #FinishCancer #IL21 #CXCL13 #OvarianCancer
275 #CancerImmunology
SENTI-101, a Preparation of Mesenchymal Stromal Cells Engineered to Express #IL12 and #IL21, Induces Localized and Durable Antitumor Immunity in Preclinical Models of Peritoneal Solid Tumors https://t.co/6d0PMlyFWa
It turns out that #tonsils aren't just for removing...
#transcriptomic + #epigenomic maps, #GC biology #IL21 #IL21R #IL4R #BCL6 #POU2AF1 #HHEX
@hamish_king @HIRN @ufdiabetes @ubclifesciences @vumcdiabetes @AtUcsf @BRIautoimmune @BarbaraDavisCtr @ucdavis @UMassDiabetes
My favorite week @ALPLM has come to a close. Thank you to all the @alplm folks who helped make the Conference on IL History happen. Also, thank you to our partners at @IllinoisPress @siupress @ILStateMuseum you make this possible! #IL21
It’s Conference on Illinois History time! #IL21
@saeedatcha I have just shared your story with my 12 year old. Inspiring, challenging and motivating. Thank you for sharing #IL21
Thank you, @vste ,
for supporting Inspire Loudoun 2021! #edtech #inspireloudoun21 #IL21 #lcps21 #educators #instructionaltechnology
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