Top Tweets for #spectrumtoolbox
Neuron-specific virus overcomes barriers to brain-related gene therapy, reports @holly_barker92 #SpectrumToolbox https://t.co/ykJJB2Eu5B
Viviana Gradinaru and her colleagues used directed evolution to engineer viruses that target the brain and steer clear of other organs. The approach follows the same principles that breeders use to select for useful traits in livestock. #SpectrumToolbox https://t.co/ykJJB2Eu5B
A new harmless virus can deliver genes to brain cells without infecting other tissues, according to early tests in mice and monkeys #SpectrumToolbox https://t.co/ykJJB2Eu5B
Work is underway in Gradinaru’s lab and others to engineer brain-specific variants that can avoid neutralizing antibodies, which accumulate throughout a person’s lifetime and may reduce the effectiveness of gene therapies #SpectrumToolbox https://t.co/ykJJB2Eu5B
The approach could be used to engineer variants with additional traits or specificity for other tissues, the researchers say #SpectrumToolbox https://t.co/ykJJB2Eu5B
In evolutionary terms, two ‘generations’ is an incredibly small amount of time, Gradinaru says. She and her colleagues achieved their results so quickly by selecting for viruses that incorporated their genetic material into the genome. #SpectrumToolbox https://t.co/ykJJB2Eu5B
Viviana Gradinaru and her colleagues used directed evolution to engineer viruses that target the brain and steer clear of other organs. The approach follows the same principles that breeders use to select for useful traits in livestock. #SpectrumToolbox https://t.co/ykJJB2Eu5B
The virus could minimize the risk of side effects from gene therapies under development for autism-related conditions, such as Angelman syndrome, Rett syndrome and fragile X syndrome #SpectrumToolbox https://t.co/ykJJB2Eu5B
A new harmless virus can deliver genes to brain cells without infecting other tissues, according to early tests in mice and monkeys #SpectrumToolbox https://t.co/ykJJB2Eu5B
Neuron-specific virus overcomes barriers to brain-related gene therapy, reports @holly_barker92 #SpectrumToolbox https://t.co/ykJJB2Eu5B
New method spotlights synaptic plasticity in living mice, reports Holly Barker #SpectrumToolbox https://t.co/7VnLDuIoTG
Using a deep-learning-based system, the group could see receptors being added to synapses each time the animals were imaged over a two-week period, confirming that their learned fear response depended on synaptic plasticity #SpectrumToolbox https://t.co/7VnLDuIoTG
The new mice, developed by Richard Huganir and his colleagues at Johns Hopkins University in Baltimore, Maryland, make it possible to visualize AMPA receptors across the entire brain #SpectrumToolbox https://t.co/7VnLDuIoTG
The method could shed light on altered synaptic function in people with autism, and the neural mechanisms responsible for the condition’s traits #SpectrumToolbox https://t.co/7VnLDuIoTG
The ability to image individual synapses across whole brain regions has promising implications for autism research, says Huganir #SpectrumToolbox https://t.co/7VnLDuIoTG
The latest Clinical Psychology Research & Chat! https://t.co/KEpEei4v9G Thanks to @Spectrum @CarlatPsych #mentalhealth #spectrumtoolbox
Using a deep-learning-based system, the group could see receptors being added to synapses each time the animals were imaged over a two-week period, confirming that their learned fear response depended on synaptic plasticity #SpectrumToolbox https://t.co/7VnLDuIoTG
The new mice, developed by Richard Huganir and his colleagues at Johns Hopkins University in Baltimore, Maryland, make it possible to visualize AMPA receptors across the entire brain #SpectrumToolbox https://t.co/7VnLDuIoTG
The method could shed light on altered synaptic function in people with autism, and the neural mechanisms responsible for the condition’s traits #SpectrumToolbox https://t.co/7VnLDuIoTG
Using a new line of mice that express a synaptic membrane receptor with a fluorescent tag, researchers have tracked changes in the strength of synapses across the brain over several days #SpectrumToolbox https://t.co/7VnLDuIoTG
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