Top Tweets for #totalSynthesis
The Nierenstein reaction converts acyl chlorides into α-chloroketones using diazomethane. The presence of HCl prevents a competing Wolff rearrangement.
The reaction has been applied in the #TotalSynthesis of (-)-Dysibetaine by Kobayashi and co-workers.
References in thread!
The Finkelstein reaction converts alkyl halides or sulfonates into other halides via an SN2 exchange with corresponding halide salts.
Overman & co-workers exchanged an -OMs for a chloride using LiCl in the #TotalSynthesis of (-)-Strychnine @UCIChemistry
References in thread!
Recent publication on Total synthesis of myxadazoles A1, A2, and B by Dr. D. Srinivasa Reddy's group from #CSIRIICT.
https://t.co/IBcpfYnLET
@CSIRIndia @IndiaDST
#totalsynthesis #naturalproducts #OrganicChemistry #medicinalchemistry #Myxadazoles #ResearchPublication
The Hofmann elimination generates alkenes from quaternary ammonium salts when treated with base, expelling an amine.
The reaction has been applied in the #TotalSynthesis of (-)-Quinine by Woodward and co-workers @HarvardCCB to generate a terminal alkene.
References in thread!
Reference for the #TotalSynthesis of (±)-Longifolene:
https://t.co/wWZgUqc5d5
Explore more reactions and their synthetic applications and download the free app!
https://t.co/hqjf3HVCmN
In the DeMayo reaction, the enol of a 1,3-dicarbonyl and an alkene undergo [2+2] cycloaddition. Retro-aldol of the resulting cyclobutanol yields a 1,5-dicarbonyl.
This has been applied in the #TotalSynthesis of (±)-Longifolene by Oppolzer & co-workers.
References in thread!
![SynStrategy's tweet photo. In the DeMayo reaction, the enol of a 1,3-dicarbonyl and an alkene undergo [2+2] cycloaddition. Retro-aldol of the resulting cyclobutanol yields a 1,5-dicarbonyl.
This has been applied in the #TotalSynthesis of (±)-Longifolene by Oppolzer & co-workers.
References in thread! https://t.co/gQN8YfZZ7l](https://pbs.twimg.com/media/HSccSrXaoAApDJ_.jpg)
![SynStrategy's tweet photo. In the DeMayo reaction, the enol of a 1,3-dicarbonyl and an alkene undergo [2+2] cycloaddition. Retro-aldol of the resulting cyclobutanol yields a 1,5-dicarbonyl.
This has been applied in the #TotalSynthesis of (±)-Longifolene by Oppolzer & co-workers.
References in thread! https://t.co/gQN8YfZZ7l](https://pbs.twimg.com/media/HSccSrTasAAP63d.jpg)
In the Reformatsky reaction, an α-halo ester is treated with zinc to form an organozinc reagent that adds to carbonyls, yielding β-hydroxy esters.
The reaction was applied in the #TotalSynthesis of (−)-Artemisinin by Giannis and co-workers.
References in thread!
The Johnson iodination converts an α,β-unsaturated carbonyl into an α-iodoenone by treating the substrate with iodine and DMAP.
This reaction has been applied in the #TotalSynthesis of (−)-Curcusone A by Mingji Dai and co-workers.
References in thread!
Enantioselective Organocatalytic Construction of N‑Bridged Tricyclic Normorphan Skeleton: Application to the #TotalSynthesis of (+)-Peduncularine by So Hyun Jung, Ju Ha Baek, So Young Jang, Yongseok Kwon, and Hyeung-geun Park https://t.co/5mIgp9DHFm
#TotalSynthesis and Structural Revision of Rhabdobranin Reveals a Cryptic Gram-Negative Antibiotic by Helge Bode, Alan Healy et al. https://t.co/7obDeVAGUB
#TotalSynthesis of (±)-Stemocurtisine via Catalytic Carbonylation by Mingyu Zhang (@zhangmy_01), Hailey Yu, Xiao Huang, and @MingjiDai at @EmoryChem in @J_A_C_S https://t.co/0VDgHqzTDI
Concise Asymmetric #TotalSynthesis of (−)-Cribrostatin 4 by Xing-Yu Wang; Ka Lu; Wen Jiang; Lei Zheng; Xiao-Ming Zhang; Fu-Min Zhang; Hong Wang; Yong-Qiang Tu in @J_A_C_S https://t.co/kJsUtd7dEf
Recent publication on Synthesis of D-Fucp3NAc Containing Conjugation-Ready Pentasaccharide Repeating Unit Related to Acinetobacter baumannii RCH51 by Dr. Abhishek Santra’s group from #CSIRIICT.
@CSIR_IND @IndiaDST
#Glycochemistry #totalsynthesis #AcinetobacterBaumannii
The Paal-Knorr pyrrole synthesis is a condensation reaction between a 1,4-dicarbonyl and an amine to form pyrroles.
In the #TotalSynthesis of (±)-Marinopyrrole B by Clive and co-workers, the amine was added in the form of ammonium acetate.
References in thread!
#TotalSynthesis of (+)-CC-1065 by Benjamin D. Senzer and Rick L. Danheiser at @ChemistryMIT in @J_A_C_S https://t.co/GzekLg0KYJ
#TotalSynthesis and Structural Confirmation of Curcusone I by Yang-Chao Peng, Dong-Yun Lin, Xuanhao Deng, Wen Zhang, Fanbo Zhou, Xiening Ke, and Chuang-Chuang Li in @J_A_C_S https://t.co/iYaRxEZ7sl
Asymmetric #TotalSynthesis of Venezuelaene A via TEMPO+BF4–-Mediated Oxidative Nazarov Cyclization and Cascade Metathesis by Sujun Xie, Axiao Tao, Qian Wang, Jia-Dong Yu, Chengqing Ning, and Jing Xu in @J_A_C_S https://t.co/QNBhOhqndE
#TotalSynthesis of the Diterpene Alkaloid Thelepogine through Enyne Hydroamination by Christoph Etling, Matthew DiCairano, and @DirkTrauner in @J_A_C_S https://t.co/xQctUBQZHS
Directed Heterodimerization: #TotalSynthesis of (−)-Folicangine, (−)-Voafolidine, (−)-Isovoafolidine, and (−)-Tabernaesine B by Robert-Cristian Raclea, Mohammad Movassaghi at @ChemistryMIT in @JOC_OL https://t.co/1XcK53aDqh
The Kornblum oxidation uses DMSO and base to access aldehydes, ketones, and 1,2-dicarbonyls from alkyl or benzyl halides, or α-halo esters.
The reaction was applied by Nicolaou and co-workers @RiceUniversity in the #TotalSynthesis of (–)-Halichondrin B.
References in thread!
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