Top Tweets for #yPathPearls
Answer: Primary sclerosing cholangitis.
Key things to remember about PSC:
πMale predominance (5:1 male to female)
πStrong association with IBD (70% have ulcerative colitis 10% have Crohn's disease
#yPathPearls
Not everything that is nodular in the liver = cirrhosis!
Here's an entity that can mimic cirrhosis grossly & on imaging: Nodular Regenerative Hyperplasia (NRH)
NRH usually occurs as a result of vascular abnormalities, such as heart failure and outflow obstruction.
#yPathPearls
Look at this lonely dysplastic crypt from a tubular adenoma.
Let's learn from this crypt. What makes it different from its neighbors?
β
Mucin depletion
β
Nuclear enlargement, elongation & crowding
β
Hyperchromasia
β
Numerous mitotic figures
Photo taken w/ π± | #yPathPearls
One of my FAVORITE things about being a #Pathologist is answering the patient's question, "why don't I feel well?"
For this patient, the answer is right on the H&E slide!
H. pylori gastritis: a readily-treatable infection that can lead to stomach CANCER if not treated!
β€οΈπ¬β€οΈ
Mucicarmine is a tissue stain that can be used to highlight mucin in tumors, which can help one make the diagnosis of adenocarcinoma.
This positive control tissue shows how nicely mucicarmine highlights the goblet cells in small intestine.
Pretty, isn't it?
#yPathPearls
An example of how levels can make all the difference for monitoring inflammatory bowel disease activity πͺπͺπͺ
#GIpath #yPathPearls
Crypt abscesses are a fairly common finding in #GIpath, but rarely do you see such a perfect example of one in longitudinal section! #yPathPearls
Examining multiple levels on a seemingly endless tray of GI biopsies can be tiring, but can sometimes pay off immensely.
Look at how much more intestinal metaplasia is on level 2 than level 1 of this stomach biopsy.
No surprise, it's almost gone again on level 3.
#yPathPearls
Perineural invasion (PNI) by pancreatic adenocarcinoma:
β
An indicator of poor prognosis
β
Tumors with PNI utilize nerves as alternate routes of invasion
β
Invasion along nerves can generate pain in the patient
#yPathPearls
Quick #PathBoards memory tool for the hazard sign colors:
Red - Fire (fire is REDish)
Blue - Health (blue cross/blue shield HEALTH insurance)
Yellow - Chemical reactivity (think of explosive yellow powders from chemistry class)
White - Other
#yPathPearls
Kimura disease and Kikuchi disease are so easy to mix up and almost always appear together in review questions...
How's this?
kiMURa = MORE eosinophils https://t.co/BPCzWGGaxS
Kikuchi = kaBOOMi (necrosis w/o neutrophils)
https://t.co/yVkPcSw33Q
#yPathPearls
Pleomorphism: variation in size, shape and staining of cells.
This is an extreme example of pleomorphism from a uterine carcinosarcoma.
#yPathPearls
Nice example of a leiomyosarcoma π¬π
Key features:
β
Fascicular pattern on low power (orange highlights fascicles)
β
Spindle cells with "cigar-shaped" nuclei (blunt ends)
β
Frequent mitoses (arrows)
β
SMA(+), desmin(+)
#yPathPearls
#BSTpath #Pathology #PathBoards
Malakoplakia of the colon.
β
Histiocytes with defective immune response to gram(-) bacteria
β
Associated with HIV & solid organ transplants
β
Most often seen in the bladder
Do you see the characteristic Michaelis-Gutmann bodies π?
#yPathPearls #GIpath #PathBoards
Megakaryocyte mitosis in an otherwise normal bone marrow. Too many chromosomes, right?
That's because normal megs can have many more than the 46 chromosomes of our diploid cells.
It is reported that normal megs can have a ploidy of up to 64... 1472 chromosomes!!!
#yPathPearls
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