Cynthia Jackevicius

CV outcomes researcher, Pharmacist, Editor @Circoutcomes, EBM enthusiast, educator. Views are my own.

[Sanjay Kaul @kaulcsmc]

1/
Rumors of aspirin’s demise are greatly exaggerated.

Concerns with TARGET-FIRST trial:

1. Sample size estimation assumes 1% superiority of P2Y12i monotherapy (2.5% vs 3.5%) rather than conventional equivalence.

2. 80% power low for NI assessment.

https://t.co/sRkh5f0Fp9

[Sanjay Kaul @kaulcsmc]

Evidentiary landscape for P2Y12i mono-Rx vs DAPT post-ACS is as clear as mud!

Even though non-inferiority was not met technically, P2Y12i mono-Rx was associated with Rx effect ranging from 2% benefit to 68% harm.

Balancing benefit-risk post-PCI is hard.

https://t.co/kRhtjoYUpE

[Ramon Bataller @rabataller]

🚨 AI won’t replace doctors… but it can prevent them from learning how to think.

A critical article in @NEJM shows that if introduced too early in medical training, it weakens clinical reasoning.

✅ A good doctor will always need critical thinking.

N Engl J Med 2025;393:786

[Circulation @CircAHA]

AHA/ACC have released the 2025 High Blood Pressure Guideline, emphasizing prevention and early treatment to reduce cardiovascular disease risk.

Read the Guideline in @HyperAHA & @CircAHA and check out our hub with commentaries and more:
https://t.co/RUfDglhsCr...

[Rob DiDomenico @robdeedo]

Kudos to @mfiuzat, @batallah08, Robert Page & Orly Vardeny for shedding light on the training, practice, & roles of HF pharmacists. https://t.co/7U9mOuzUVQ

[Tomasz Jurga @JurgaTomek]

This is easily the strongest recent publication supporting #pharmacist co-management of heart failure therapy!

A great salute to the profession of pharmacy!
https://t.co/qWttTyx49k

[Mark Cuban @mcuban]

If you take Entresto, we now have the generic and it starts at $33.75 !

It's probably lower than your deductible or Coinsurance. So check it out with your doctor !

[JACCP @JACCPJournal]

Both ChatGPT versions demonstrated limited accuracy and reproducibility in answering drug information questions, suggesting that health care professionals should exercise caution when using ChatGPT for drug information. OPEN ACCESS: https://t.co/athYGfKCZM

[Sam Ghali, M.D. @EM_RESUS]

Hi, ER Doc here.

Everyone needs to know that taking too much Tylenol can cause liver failure and DEATH. I have seen too many people unintentionally overdose. Do NOT take more than 4 grams in one day. That’s only 8 extra strength pills! Please tell all your friends about this.

[Cynthia Jackevicius @HeartRPh]

Seeking a strong candidate as a Cardiovascular Outcomes Research Fellow! Program designed to develop cardiology pharmacotherapy & research skills for a successful outcomes research/academic career. Sites: WesternU & VA GLA. For more info and how to apply: https://t.co/gyJvzyLXEA

[Sam Ghali, M.D. @EM_RESUS]

Hi, ER Doc here.

I’ve used this account for over 10 years now to teach people about medical emergencies. It’s my birthday today and I’m hoping to hit 700K followers to be able to reach more people.

Can I get some follows and reposts to help me get there?

[JACCP @JACCPJournal]

Both ChatGPT versions demonstrated limited accuracy and reproducibility in answering drug information questions, suggesting that health care professionals should exercise caution when using ChatGPT for drug information. OPEN ACCESS: https://t.co/athYGfKCZM

[The Bee Guy @the_beeguy]

Queen #BUMBLEBEES - HELP THEM OUT!
Another Saturday morning means another vital thread concerning #bumblebee queens at this time of year!
Please #retweet/#share as EVERY QUEEN BEE THAT SURVIVES GETS TO ESTABLISH A NEST that otherwise would not happen. Let me explain.
1/11
#bees

[Sanjay Kaul @kaulcsmc]

API-CAP
NI margin of HR of 2! Really!!
Is the 41% loss of efficacy acceptable given no benefit in terms of major bleeding which is a more stringent criterion for clinically relevant bleeding even though the latter was the prespecified bleeding endpoint?

[The Bee Guy @the_beeguy]

It’s that time of year - people asking us about #bumblebees - WHY THEY’RE SEEING THEM ON THE GROUND - so here’s a thread to explain what they’re up to.
Please #retweet.
Every #queen that survives means a new colony that gets to exist & produce new queen #bees for next year!
So this is important to share.
Thank you.
1/9

[Circulation @CircAHA]

In anticoagulated patients with atrial fibrillation, bleeding was strongly associated with new cancer diagnoses: an opportunity for cancer diagnosis at an earlier stage @denniskomd @HeartRPh @DouglasLeeMD @dr_mike_fradley @husam247 https://t.co/pxF7ieNs73

[Cynthia Jackevicius @HeartRPh]

@MoShurrabMD

[Felice Gragnano @FeliceGragnano]

Concurrent use of #amiodarone is associated with an increased risk of major bleeding in patients on #DOACs. Read more in a new study in #EHJPharmacotherapy 💊

👉 https://t.co/OiQpNkCbdO

@EditorEHJCVP 👨‍⚕️
@ESC_Journals 📚
@escardio ❤️

#Cardiology #CardioMed #CardioEd

[Rosa Ritunnano @RRitunnano]

Instead of listing my publications, as the year draws to an end, I want to put pressure on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research

[Jason H. Wasfy, M.D. @jasonwasfy]

"Instead of progress, the rise of a health care quality industrial complex has added measurement bloat, cost, and waste, with little improvement in patient outcomes."
https://t.co/SOI1tQ9Hi5
@sbradley_heart @CircOutcomes @ACCinTouch

[Cynthia Jackevicius @HeartRPh]

@husam247 @WCHospital @PMunkCardiacCtr Congrats, @husam247!! So well deserved! 🎉