We're hiring! The NIHR-funded @SHORTERtrial seeks a Senior Research Fellow for the Process Evaluation. A great opportunity for qualitative/mixed-methods researchers to step into a senior role and develop leadership skills @EdinburghNapier
Apply now ⬇️
https://t.co/xAfPZBDaf3
#CCRdownunder24 congress just started
1st study ADAPT-Sepsis published in @JAMA_current
Procalcitonin guided protocol ⬇️ antibiotic treatment duration by 1day (significant)
but 28-day mortality non-sign⬆️by 7% (relative risk): from 19.4 to 20.9%
https://t.co/rK5vR6EP9X
Published in JAMA with #CCRdownunder:
In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein.
@CritCareReviews
https://t.co/j6v8imY0AX
@James_West_PhD@charlot_summers@PLOSGPH That's terrible and very detrimental to ECR. I'm assoc editor and I similarly get passed on papers that have been in the system for ages with little/no progress. Makes it v difficult if the manuscript needs a lot of work to be ready for publication! Agree, its broken.
7d is not a country mile away from standard care in the UK. Recognising microbiological cure is hard. Antibiotics are not without harm. Try @SHORTERtrial@hellyerthomas
Presented at #CCCF2024:
In the BALANCE randomized clinical trial, patients with bacteremia were assigned to 7 or 14 days of appropriate antimicrobial therapy, and 7 days of therapy was found to be noninferior to 14 days. Full trial results: https://t.co/fAeAPSDZ4b
This is what I gleaned the working group recognised and will seek to address (1) the infeasibility of training in academia and two medical specialities (2) academia now linked to pay penalties through slower progression and diminished merit awards….
More posters today from trial managers Gillian Watson and @AGrSwain Come and find out more about recruitment during COVID-19 and lessons in running dental trial @enhanced_trial#ICTMC2024
7 days in the week. 5 digits on your hand. So naturally antibiotic courses are multiples of 7 or 5 🤔.
@SHORTERtrial large @NIHRresearch funded trial investigating short (5 day) course of antibiotics vs SoC in sepsis. Challenging the 'week's course' dogma.
Challenging dogma if evidence non‑existent, weak, outdated part II
💊give a week’s course of ABT
🍬standardized management for DKA
🫀icarbonate improves contractility in severe acidosis
⚗️hypophosphatemia needs correction
🔓https://t.co/T8xd59nC3j
Part I
🔓https://t.co/jJuWqnTRuc
New data released today in @TheLancet shows that without urgent action, antimicrobial resistance could kill 39 million people by 2050.
Deaths and inequities from the global antibiotic emergency are increasing and now is the time to take urgent action.
https://t.co/O91bRl2G91
NHIP Academy was delighted to support eight exceptional researchers throughout their application process to be successfully awarded the new Senior Clinical and Practitioner Research Award (SCPRA) from the @NIHRresearch (NIHR).
Read the full story here: https://t.co/x1ryArc6Ae
There is a crisis in clinical academia in the UK. We talk of the need to expand medical schools, embed research into the NHS to improve care, & the importance of a vibrant life sciences sector for the economy of the UK, & yet we seem unable to tackle the underlying issues 1/9