Tom Hellyer

Clinical academic critical care medicine.
Antibiotic stewardship in critically ill patients.
Clinical deputy director Newcastle CTU.
@SHORTERtrial
@RiscSepsis

[EPPiC Warwick @EPPiC_Warwick]

CoReCCT trials are now open to recruitment
@DarkNatter @gazkitch @ICS_updates @WarwickCTU @KeithCouper @EPPiC_Warwick @Luigi_ICM @dfmcauley @DanJHadfield @ProfLouiseR @perkins_gd @WUTHresearch

[Tom Hellyer @hellyerthomas]

@GoshaWojcik @SHORTERtrial @EdinburghNapier Great opportunity to join the SHORTER team running the process evaluation with @GoshaWojcik .

[Gosha Colquhoun @GoshaColquhoun]

We're hiring! The NIHR-funded @SHORTERtrial seeks a Senior Research Fellow for the Process Evaluation. A great opportunity for qualitative/mixed-methods researchers to step into a senior role and develop leadership skills @EdinburghNapier

Apply now ⬇️

https://t.co/xAfPZBDaf3

[Giovanni Landoni, MD @giovannilandoni]

#CCRdownunder24 congress just started

1st study ADAPT-Sepsis published in @JAMA_current

Procalcitonin guided protocol ⬇️ antibiotic treatment duration by 1day (significant)

but 28-day mortality non-sign⬆️by 7% (relative risk): from 19.4 to 20.9%

https://t.co/rK5vR6EP9X

[Tom Hellyer @hellyerthomas]

@DrToddLee @ABsteward @BradSpellberg Agree. Implausible. RoB not reported.

[JAMA @JAMA_current]

Published in JAMA with #CCRdownunder:

In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein.

@CritCareReviews

https://t.co/j6v8imY0AX

[Tom Hellyer @hellyerthomas]

@BradSpellberg https://t.co/NigSQZkf7y

[Critical Care Reviews @CritCareReviews]

Chief Investigator @darknatter shares the findings from the #ADAPTsepsistrial at #CCRdownunder

@adaptsepsis @FBMH_UoM @NIHRresearch @EPPiC_Warwick @NCAresearchNHS @JAMA_current

[Tom Hellyer @hellyerthomas]

@James_West_PhD @charlot_summers @PLOSGPH That's terrible and very detrimental to ECR. I'm assoc editor and I similarly get passed on papers that have been in the system for ages with little/no progress. Makes it v difficult if the manuscript needs a lot of work to be ready for publication! Agree, its broken.

[Tony Rostron @RostronTony]

7d is not a country mile away from standard care in the UK. Recognising microbiological cure is hard. Antibiotics are not without harm. Try @SHORTERtrial @hellyerthomas

[NEJM @NEJM]

Presented at #CCCF2024:

In the BALANCE randomized clinical trial, patients with bacteremia were assigned to 7 or 14 days of appropriate antimicrobial therapy, and 7 days of therapy was found to be noninferior to 14 days. Full trial results: https://t.co/fAeAPSDZ4b

[Tony Rostron @RostronTony]

UK critical care could offer @SHORTERtrial to patients. @hellyerthomas

[Simon Mead @smead2]

This is what I gleaned the working group recognised and will seek to address (1) the infeasibility of training in academia and two medical specialities (2) academia now linked to pay penalties through slower progression and diminished merit awards….

[Newcastle Clinical Trials Unit @NclCTU]

More posters today from trial managers Gillian Watson and @AGrSwain Come and find out more about recruitment during COVID-19 and lessons in running dental trial @enhanced_trial #ICTMC2024

[Newcastle Clinical Trials Unit @NclCTU]

Come and see @Dean_Allerton to learn more about #eConsent in the @IBDResponse study #ICTMC2024

[Tom Hellyer @hellyerthomas]

7 days in the week. 5 digits on your hand. So naturally antibiotic courses are multiples of 7 or 5 🤔.
@SHORTERtrial large @NIHRresearch funded trial investigating short (5 day) course of antibiotics vs SoC in sepsis. Challenging the 'week's course' dogma.

[Intensive Care Medicine @yourICM]

Challenging dogma if evidence non‑existent, weak, outdated part II
💊give a week’s course of ABT
🍬standardized management for DKA
🫀icarbonate improves contractility in severe acidosis
⚗️hypophosphatemia needs correction
🔓https://t.co/T8xd59nC3j
Part I
🔓https://t.co/jJuWqnTRuc

[Prof. Dame Sally Davies @UKAMREnvoy]

New data released today in @TheLancet shows that without urgent action, antimicrobial resistance could kill 39 million people by 2050.

Deaths and inequities from the global antibiotic emergency are increasing and now is the time to take urgent action.

https://t.co/O91bRl2G91

[PEACH @PEACH_Study1]

💥💥💥MAIN RESULTS💥💥💥

The PEACH team are delighted to finally share the main results of this study!
@CarrolEnitan @j_sandoe @emma_tj1 @Dr_JoanneEuden @LBrookesHowell @DetelinaGrozeva @CTRCardiffUni @UniversityLeeds and many others.

https://t.co/g9PWSEXieF

[Newcastle Health Research Partnership @NCLPartnership]

NHIP Academy was delighted to support eight exceptional researchers throughout their application process to be successfully awarded the new Senior Clinical and Practitioner Research Award (SCPRA) from the @NIHRresearch (NIHR).

Read the full story here: https://t.co/x1ryArc6Ae

[Charlotte Summers @charlot_summers]

There is a crisis in clinical academia in the UK. We talk of the need to expand medical schools, embed research into the NHS to improve care, & the importance of a vibrant life sciences sector for the economy of the UK, & yet we seem unable to tackle the underlying issues 1/9

[Tom Hellyer @hellyerthomas]

Amazing effort by the @SHORTERtrial sites and by the @NclCTU team to get off to such a good start. Keep on going!

[SHORTERtrial @SHORTERtrial]

19 sites open and 168 patients have had the opportunity to participate in research! Wow! Incredible work by all the @SHORTERtrial sites. Keep up the good work. More sites to open soon. 🎯👏👏👏
@NIHRresearch @NclCTU @UniofNewcastle @hellyerthomas