Hong-Hee Won

Human genetics and genomics

[Nicholas Fabiano, MD @NTFabiano]

Chocolate consumption enhances cognitive function.

There is powerful correlation between chocolate intake & the number of Nobel Prize recipients.

[Marios Georgakis @MariosGeorgakis]

I often post how studying the effects of genetic variation on gene expression can reveal disease mechanisms & novel drug targets🧬-->💊

Our paper at @AJHGNews links disease GWASs with single-cell gene expression to uncover cell-specific drivers of atherosclerosis👇[1/9]

[Veera Rajagopal  @doctorveera]

Nice systematic analysis of gene convergence between common and rare variant GWAS discoveries.

Not often we see common and rare variant studies implicating the same set of genes for a trait. This convergence is rare particularly for traits under strong selection like early onset neuropsychiatric diseases.

However, if we take a step backward, we can see that, even though common and rare disease variants do not converge on the same genes, they do converge on the same pathways.

Analyzing 373 phenotypes with both common and rare variant discoveries available, the authors find that genes implicated by rare and common variants implicate the same pathways for >75% of traits.

Paper:
Wright et al. Common and rare genetic variants show network convergence for a majority of human traits. medRxiv 2025

https://t.co/dVQvxHnBye

[Akl Fahed @aklfahed]

New preprint from our group advancing genetic discovery and biologic understanding of obesity

- Multi-trait GWAS of >2 million people

- Discovered 743 loci including 86 novel

- Defined 11 distinct obesity endotypes driven by metabolic resilience, insulin physiology, beta cell compensation, immune dysregulation, neuroendocrine signaling, and lipid metabolism

Manuscript: https://t.co/YkIEOlKGkk

Thread:

[Marios Georgakis @MariosGeorgakis]

My new weekly read list with 5 interesting papers from the fields of genetics, omics & deep phenotyping 🧵

1⃣snRNAseq provides proof for adult human hippocampal neurogenesis
2⃣A multitrait GWAS of adult obesity
3⃣A review of FDA-approved AI medical tools
4⃣A new deep learning-based neuroimaging phenotype of white matter microstructure
5⃣Proteomic signatures of neurodegenerative pathologies

[Joseph Everett (WIL) @JEverettLearned]

Happiness is highly linked to how focused you are on what you're doing.

A wandering mind is an unhappy mind.

[Hong-Hee Won @hongheeW]

@MinSeoKim_MD Thank you for your great efforts on this fantastic work! https://t.co/6rpByTIxRP

[Min Seo Kim, MD, MSDH @MinSeoKim_MD]

Delighted to share the preprint on the largest obesity GWAS to date!

GWAS from >2 million participants

Key:
✳️13% increase in loci discovery
✳️Identified 11 obesity genetic clusters (endotypes)
✳️Obesity management should be as diverse as the condition itself

Thread👇

[JAMA Network Open @JAMANetworkOpen]

A polygenic risk score (PRS) derived from a European GWAS identified those at high risk for Alzheimer dementia in Korea, emphasizing the transferability of PRSs and suggesting the importance of enriching diversity in genetic studies of Alzheimer disease. https://t.co/6bKfErNFn5

[Hong-Hee Won @hongheeW]

@JAMANetworkOpen Congratulations @normal_hyuk. Look forward to developing PRS further to improve prediction performance in the Korean population.

[Nature Human Behaviour @NatureHumBehav]

Won et al. compare genetic associations with subjective wellbeing (SWB) in Korean and European populations, and show significant cross-population genetic correlations. @hongheeW

https://t.co/12VMkkhjfk

[Hong-Hee Won @hongheeW]

@NatureHumBehav Congratulations @soyeon2019 on this work and getting a PhD + becoming a Broadie.

[Hong-Hee Won @hongheeW]

@heikorunz @FinnGen_FI @uk_biobank @Nature @ben_b_sun Congratulations @heikorunz and thank you for sharing the sum stats of your study.

[Brain @Brain1878]

Ko et al. identify 30 new genetic markers for occupational attainment, and show that high levels of occupational attainment are associated with reduced risk for Alzheimer’s disease, even after taking educational attainment into account. https://t.co/xUgdx2C6L0

[Pete Kraft @GENES_PK]

Yes, Virginia, summary statistics from many cancer genome-wide association studies are publicly available! #sumstats #cancer #gwas https://t.co/XecZJOHfB3

[Hong-Hee Won @hongheeW]

Happy to share our work just published in European Heart Journal @ehj_ed. Great work by @MinSeoKim_MD , @amitvkhera et al.

[EHJ Editor-in-Chief @ehj_ed]

Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies. Discover more in EHJ! https://t.co/HOgWqBkemn

#CVD #CAD #stroke #adiposity #metaanalysis #cardiotwitter @escardio @ESC_Journals

[Amit V. Khera @amitvkhera]

Our lab is expanding!

We seek outstanding comp scientists to join our multidisciplinary team (https://t.co/VG1O5suokg)

working at the interface of genetics, ML, and clinical medicine.

Please RT!

Apply today or DM with ?’s:

https://t.co/puqPX3bpQj
https://t.co/7fNbv9POSx

[EHJ Editor-in-Chief @ehj_ed]

Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies. Discover more in EHJ! https://t.co/HOgWqBkemn

#CVD #CAD #stroke #adiposity #metaanalysis #cardiotwitter @escardio @ESC_Journals

[Saori Sakaue @saorisakaue]

📣Data Release Alert📣 On our 220 cross-pop deep-phenotype GWAS project, I have compiled all 220*3 GWAS summary statistics, and Super @masakanai deployed them into the beautiful web portal!! You can search and download everything at https://t.co/DXuNHv0Ocd 🧵

[Sek Kathiresan MD @skathire]

So, your LDL is >190.

Well, your risk of suffering a heart attack is powerfully dependent on your polygenic background (even after accounting for all other risk factors)

P.S. what @amitvkhera and I have been saying for several years

https://t.co/BAeY5g8zyM