Sang-Hyuk Jung

Postdoctoral researcher at University of Pennsylvania

[Eric Topol @EricTopol]

The genomics of metabolic syndrome in ~5 million people identifies over 1,300 associated loci, enrichment primarily in brain tissue, a refined polygenic risk score, an and relationship with various clinical conditions
https://t.co/wxbmYxODKx @NatureGenet @hongheeW

[Sang-Hyuk Jung @normal_hyuk]

Happy to share that our new paper, 'Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks,' is now published in the Journal of Translational Medicine.

Paper: https://t.co/8yPtFPyAMF

#glaucoma #genetics

[Sang-Hyuk Jung @normal_hyuk]

Thrilled to share another new paper, 'Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss,' is out at BMC Medicine with Young Chan Lee and @dokyoon_kim.

Paper: https://t.co/qRJ4DqXXEP

#genetics #hearingloss #lifestyle

[Sang-Hyuk Jung @normal_hyuk]

Delighted to share our new paper, Polygenic risk score-based phenome-wide association study of head and neck cancer across two large biobanks, is out at BMC Medicine with Young Chan Lee and @dokyoon_kim.

Paper: https://t.co/61TVZLZRvh

[BMC Medicine @BMCMedicine]

Discovery of #polygenic #riskfactor-based associations between head and neck #cancer -> phenotypic traits (e.g. #alcoholism #smoking #respiratorydisease)

Published in #BMCMedicine
https://t.co/X50oUFAu3G
Data from #PennMedicineBiobank #UKBiobank
@dokyoon_kim @PennMedicine

[Dokyoon Kim @dokyoon_kim]

Excited to share our recent work: "#SingleCell Masked Autoencoder: An Accurate and Interpretable Automated Immunophenotyper"
scMAE model transforms high-throughput single-cell cytometry, offering a scalable, robust, and precise immunophenotyping tool.@EJohnWherry @_ImmuneHealth_

[Dokyoon Kim @dokyoon_kim]

@suhgoood presents "Improved #Alzheimers Disease Risk Prediction and Stratification through a Combined Genetic Risk Score of Common and Rare Variants". Catch this insightful talk in the "Genetic Analysis of Neurological Disorders" session at 1:45pm on 11/3. #ASHG23 @UPennGCB

[Pradeep Natarajan @pnatarajanmd]

Delighted to contribute to this Mendelian randomization paper led by @hongheeW raising the prospect of risks from vitamin over-supplementation particularly when deficiency does not exist https://t.co/CKesZY1HvF @BMCMedicine

[Penn Medicine CSO @PennMedCSO]

Discovering #comorbid diseases using an inter-disease interactivity network based on @uk_biobank #PheWAS data ft. Yonghyun Nam, @normal_hyuk, Jae-Seung Yun, @viveksrm24, @dokyoon_kim (@UPennDBEI/ @UPennIBI), @5inghalp & @_anuragverma (@PennGenetics) https://t.co/hMl4ur5tw9

[Dokyoon Kim @dokyoon_kim]

Happy to share our new paper, Genome-wide #PRS for Hypertensive Disease during Pregnancy can also Predict the Risk for Long-term Cardiovascular Disease, is out at @AJOG_thegray.
Great job, Manu and Seung Mi!
https://t.co/IvckGcKhd0

#WomensHealth @UPennDBEI @UPennIBI @UPennGCB

[Carlos Cruchaga @ccrugom]

We put together 14 cohorts and 13K samples to perform the largest multi-ethnic amyloid PET GWAS identifying four loci associated with brain amyloidosis and #Alzheimer disease risk. @WUADRC @WashUNeurology @Neuro_Genomics https://t.co/bIDCRSuywF

[Sang-Hyuk Jung @normal_hyuk]

ICD2Vec: Mathematical representation of diseases, is out in @JBI_Journal
https://t.co/qC1zHXzaQ9

[PRS papers @PRS_pubmed]

Genetic network structure of 13 psychiatric disorders in the general population https://t.co/0WGWvmYIzK

[Zhen Miao @ZhenMiao2]

I'd like to share a very cool review paper on interpreting deep learning (https://t.co/eGW7kVq4MT), from @sara_mostafavi Lab. I think researchers should definitely try using the ideas summarized here in their own DL models to exploit what has been learned by NNs. 1/n

[Dokyoon Kim @dokyoon_kim]

Happy to share that our paper, Discovering #comorbid diseases using an inter-disease interactivity network based on @uk_biobank #PheWAS data, is out in @OUPBioinfo. The predicted comorbidities were verified using EHR data. @UPennDBEI @UPennIBI

https://t.co/Y1IQCh8JpM

[PRS papers @PRS_pubmed]

A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variants https://t.co/5MJQ8hIUV3

[Sang-Hyuk Jung @normal_hyuk]

Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes https://t.co/QkHJKYDis1 via @JAMANetworkOpen part of @JAMANetwork

[Dokyoon Kim @dokyoon_kim]

Our new paper, Development and Validation of a Novel Prognostic Immune and Nutritional Index (PINI) for #ColonCancer is out at @BrJCancer. It'd be helpful for personalized treatment strategy as the complement of the TNM staging system. @UPennDBEI @UPennIBI
https://t.co/8m8wGWJbMh

[Pigeons & Planes @PigsAndPlans]

Daft Punk have announced their retirement via a video titled “Epilogue” posted to their YouTube this morning.

Their publicist also confirmed the split to Variety. Thank you for 28 years of life-changing music.