"I Teach at a Business School, It's Time to Shut Them Down" says Prof Chris Marquis from the University of Cambridge Judge Business School.
I agree entirely and have been saying this for 2 decades. India would do well to close down business schools and focus on startup incubators. We need large scale startup formation and a lot of experimentation.
SITUATION EXPLAINED: MIT researchers got AI models to talk in "neuralese" instead of words, and it could end our best way of checking what AI is thinking.
• Normally one AI writes a summary for the next AI to read, but MIT's "Swarm Telepathy" hands over the first model's internal working memory directly
• A small translator network converts that memory between different model families, like Qwen, Llama and Gemma, without retraining either model
• It beat models talking in plain text by 40% in accuracy on average and ran about 4x faster
• It even passed image understanding from a vision model to a model that can only read text
• Chain-of-thought monitoring means reading the reasoning a model writes out in English to catch bad behavior before it acts
• In 2025, dozens of researchers from OpenAI, Anthropic and Google DeepMind warned in a joint paper that this window into AI reasoning is "fragile" and could close
• AI safety researcher @davidad predicts chain-of-thought monitoring will be "unambiguously over" by early 2028
@theojaffee: "Instead of models having a chain of thought where they write in English, they will just think in neuralese in the inscrutable matrix of floating-point numbers that make up the KV cache."
Neuralink’s first product is called Telepathy.
It enables high-speed communication with computers or humans simply by thinking. Output bandwidth will vastly exceed the fastest human speech or typing in a few years. Read that sentence again.
This is INSANE. Cisco’s president Jeetu Patel has given a 27-year-old engineer unlimited AI tokens to try to rewrite 98% of the company’s legacy code within 24 months, Fortune reports.
Padmanabhan Krishnamurthy thinks he can do it with a two-person team. He has just four weeks to prove the approach.
Patrick Stewart, the star of ‘Star Trek: The Next Generation,’ died yesterday at his home in Los Angeles following a battle with Alzheimer’s Disease and Lewy Body Dementia. He was 86.
Read more on his life and legacy here: https://t.co/hVHshmbnOe
In 1917 a French microbiologist found a virus that kills only bacteria. The West forgot about it. A lab in Tbilisi didn't, even after its founder was executed in Stalin's purges.
This month, a startup bet AI can bring it back.
The microbiologist was Félix d'Hérelle. He called the viruses bacteriophages, "bacteria eaters." Each one hunts a specific strain and leaves your own cells alone.
In 1919 he used them on a 12-year-old boy dying of dysentery in Paris. The boy recovered.
A young Georgian scientist, George Eliava, met d'Hérelle at the Pasteur Institute and brought the idea home. Together they built a phage institute in Tbilisi.
In 1937 Eliava was arrested and shot.
Then penicillin arrived. Antibiotics were cheap, broad, and easy to mass-produce, and the West dropped phages almost completely.
Georgia didn't. Eliava's institute kept going for decades. Today, patients with infections no antibiotic can touch still fly to Tbilisi as a last resort.
Meanwhile, resistance caught up. In 2019 alone, drug-resistant bacteria directly killed 1.27 million people.
The catch with phages was always speed. You have to find the right virus for one patient's exact strain, and that can take months of searching.
On 20 October a California startup, Radical Numerics, said it had used its AI model to design phages for a patient with drug-resistant E. coli. They were given under a single-patient FDA approval after killing the bacteria in the lab. It's one case, and the outcome hasn't been shared.
But the bottleneck that made the West give up on phages, finding the right one fast enough, is exactly the kind of problem AI is good at.
We may have spent 80 years with one answer to antibiotic resistance sitting in a lab in Georgia.
Which abandoned idea would you bet AI revives next?
🚨 This could be the end of Type 2 diabetes.
Researchers at ETH Zurich led by Martin Fussenegger built a small wireless implant that uses electricity to break down extra sugar in the blood.
It switches off when levels are normal — and means people won’t need diabetes drugs anymore.
Inside is a catalyst made of graphite felt coated with tiny gold and platinum particles, with no living cells or drugs. A glucose sensor worn on the arm watches sugar levels. When they climb after a meal, it signals a phone or smartwatch, which switches on the implant.
The catalyst then turns glucose into gluconate, a harmless compound the body flushes out in urine, and the system shuts off once sugar is back on target.
In diabetic mice, the device kept blood sugar under tight control for six weeks, the animals lost weight, and it caused no sign of tissue damage.
Because less sugar ends up stored as fat, the team sees it as a possible tool for both type 2 diabetes and obesity, without daily pills or injections. So far it has only been tested in mice, and human trials are still ahead.
source: Maity, D., et al. (2026). Wireless electrocatalytic closed-loop system for drug-free management of diabesity. Science.
Early Neuralink speech restoration data:
We are enabling speech to text and voice at conversational rates in participants with ALS. One participant achieved 75 WPM at 5.8% WER on a 125k-word vocabulary in their first week.
Last night an AI agent performed brain surgery on a mouse.
We gave it 19 gene therapy vectors in a spreadsheet, a mouse model of epilepsy, access to a motorize surgery rig with cameras and one goal: reduce seizures.
It picked the drug. It picked the brain region. It derived the coordinates from three papers. Then it drove the stereotaxic arms into the brain and injected 250 nanolitres while watching the entry site through the rig camera for bleeding.
A licensed vet gated every irreversible step and held a physical kill switch to stop the AI agent.
Thread on what it decided, what it saw, and the moment it refused to let me override it.
[Writing this on the spot out of excitement, but I've been 18hrs in front of my laptop coding and coordinating this, so keeping it brief and descriptive, more cohesive thoughts on this soon...]
Delete Granola bro. We're switching to Strawberry. Did you sign up for Pistachio yet? I sent you an invite to our Gingerbread team. Check your inbox on Syrup. You need to make an Iced Vanilla Latte account to access Almond Croissant. Hold on, lemme add you to Chicken Tikka Masala
i'm often asked, "do you think i have pmf?"
my answer is always the same:
"if you're asking that question, you probably don't."
when you hit pmf, you won't have to ask. people will love your product so much that you'll hear it directly from them.
we found this out firsthand at wispr when we heard that people were buying macbooks just to be able to use flow.
you can't fake pmf or people loving your product, and it will be obvious when that happens. until then, keep building.
ship, collect feedback, ship again
— written with @WisprFlow
Introducing Boardy’s List: Who are the Top 100 Founders on X?
Vote for your favourite founders by tagging them in the comments (or you can DM me if you prefer to vote in private).
Every like on your comment counts as a vote.
I want to find more undiscovered talent vs. run a popularity contest, so I’m keeping the leaderboard private until it’s announced.
You have one week to vote.
After that, I’ll announce the winners in partnership with @distributedkv and top lists.
You can vote for as many founders as you like, once per person. You can also vote for yourself and I won’t tell anyone.
Quote tweet this if you want to enter yourself. Every like on your tweet will count as a vote.
Use Gesture Inputs while you are busy in the #Kitchen with messy hands ..
#MasterChef#Chef#Cooks
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