Hoang-Anh T Phan, Ph.D.

Postdoc Fellow @ChildrensPhila | Ph.D. @PennChemistry ‘23 | chemical biologist | music enthusiast

[Hoang-Anh T Phan, Ph.D. @hphan95]

@chenao_zhang @biorxiv_immuno Thank you so much, Chenao 😊!

[Hoang-Anh T Phan, Ph.D. @hphan95]

Excited to share my latest first-author manuscript, now available as a preprint on @biorxiv_immuno! We introduce VLP-Open HLA, a new protein-based nanoparticle platform for T-cell screening studies, leveraging SpyTag/SpyCatcher bioconjugation chemistry and engineered open MHC-I!

[SgourakisLab @SgourakisLab]

Tired of running separate experiments using ELIspots and tetramers? Then use VLP-Open HLA - a versatile nanoparticle platform that can screen for #Tcell responses in vitro. Using SpyTag/SpyCatcher chemistry to conjugate our loadable, open #MHC-I molecules on engineered protein-based nanoparticles, our platform can efficiently detect and activate antigen-specific T cells at scale.
https://t.co/JfULsdzW6Z
https://t.co/Ezx6HEX9nN

[Hoang-Anh T Phan, Ph.D. @hphan95]

@HaotianDu4 @biorxiv_immuno Thank you, Haotian!

[bioRxiv Immunology @biorxiv_immuno]

Ready-to-load MHC-I Nanoparticles for High-throughput T cell Screening Studies https://t.co/i2hIbaGUp7 #biorxiv_immuno

[Nature Biotechnology @NatureBiotech]

@StanfordUChem @CHOP_Research @PennMedicine @scrippsresearch @bioe_stanford @StanfordCancer @czbiohub @PossuHuangLab @HaotianDu4 @SgourakisLab .@ChildrensPhila, @Stanford researchers reveal and refine new immunotherapy platform with increased potential to target cancer cells #NBTintheNews https://t.co/TM0aHWe7Pn

[Hoang-Anh T Phan, Ph.D. @hphan95]

Grateful to contribute a small part to this exciting effort in developing a new protein-based, MHC-targeting immunotherapy platform. Congrats again to lead author @HaotianDu4 and all the incredible co-authors at @ChildrensPhila, @Penn, and @Stanford!

[Nature Biotechnology @NatureBiotech]

Targeting peptide antigens using a multiallelic MHC I-binding system https://t.co/mF9qVtgNka

[Possu Huang Lab @PossuHuangLab]

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens

TRACeR for MHC-I: https://t.co/AGzIC4Ooun
TRACeR for MHC-II: https://t.co/U4lRENyrGu

@HaotianDu4 @ljjchem @SgourakisLab @StanfordBiosci @UPennAllergyImm @CHOP_Research

[SgourakisLab @SgourakisLab]

Proud to unveil TRACER-I, a de novo protein platform developed through 5 years of collaboration with @PossuHuangLab. By recognizing diverse #MHC-I antigens (cancer, autoimmune & pathogenic), we're paving the way for more accessible immunotherapies. Congratulations to @HaotianDu4 and the incredible Team from @StanfordBioX , @UPennAllergyImm and @CHOP_Research ! https://t.co/DqsV7xOMWe

[Hoang-Anh T Phan, Ph.D. @hphan95]

A paper published by my Ph.D. lab in ACS Bioconjugate Chem last month on the fluorescent unnatural amino acid acridon-2-ylalanine (Acd) synthesis and its applications features an analogous DPP-4 probe design, using Acd instead of coumarin as fluorophore.

https://t.co/3Fd7sohrPz

[Hoang-Anh T Phan, Ph.D. @hphan95]

My first-author paper on novel DPP-4 fluorescent probe design is now published in @ChemComm as part of their 60th Anniversary Collection! This was made possible by co-authors Yanan & Sam, my Ph.D. advisor, and everyone in the Petersson lab @PennChemistry

https://t.co/HqnghZFwIJ

[CHOP Research @CHOP_Research]

📸 Snapshots from #NPAW2024 last week! To all our postdoctoral fellows at @ChildrensPhila: THANK YOU! 🙌 And a special thanks to our Office of Academic Training & Outreach Programs + @CHOP_Postdocs for a fun & educational roster of events!

[SgourakisLab @SgourakisLab]

New preprint alert! Our lab has captured the first glimpse of how #TAPBPR selects #antigens for #MHCI presentation. Focusing on a high-fidelity #immune checkpoint, our structural insights guide new approaches to #vaccine design and #cancer #immunotherapy.
https://t.co/1zpK0XZBFz

[The Nobel Prize @NobelPrize]

Katalin Karikó and Drew Weissman – awarded the 2023 #NobelPrize in Physiology or Medicine – discovered that base-modified mRNA can be used to block activation of inflammatory reactions and increase protein production when mRNA is delivered to cells.

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

[Penn @Penn]

Katalin Karikó and Drew Weissman, Penn’s historic mRNA vaccine research team, win 2023 @NobelPrize in Medicine https://t.co/ztt9x0Iumu #nobelprize

[Hoang-Anh T Phan, Ph.D. @hphan95]

@jorge_ortzc Congratulations again, Dr. Ortiz-Carpena!!!

[Hoang-Anh T Phan, Ph.D. @hphan95]

@jeezluisjorge Thank you, Christopher! Hope all is well with you.

[Hoang-Anh T Phan, Ph.D. @hphan95]

I am honored and humbled to be recognized for my service and contributions to graduate student life at Penn. Congratulations to my fellow awardees and thanks to all who have mentored/inspired me along the way!

[Penn @Penn]

Thirteen Class of 2023 graduate students from @AnnenbergPenn, @PennGSE, @pennlaw, @PennMedicine, @PennSAS, and @WeitzmanSchool have received 2022-23 graduate leadership awards.
https://t.co/GioTdJ7VR4

[Hoang-Anh T Phan, Ph.D. @hphan95]

@SamasaBakary Thank you so much!

[Penn Arts & Sciences @PennSAS]

Congrats to Alison Knasin (Ph.D. in chemistry) and Hoang Anh Phan (Ph.D. in chemistry) who received 2022-23 Graduate Student Leadership Awards for their service and lasting contributions to graduate student life at @Penn. https://t.co/7edrXYNLdL @PennChemistry