Human Blastoid

Human stem cell-based models for blastocyst and peri-implantation development | #blastoid

[Gert Jan C. Veenstra @GJCVeenstra]

New human blastoid work out @Nature
By my count this is already the 5th report on human blastoids
Exciting to see these stem cell-based models take off @NRivron

https://t.co/LjD70VocNo

[Magdalena Zernicka-Goetz @ZernickaGoetz]

Very happy I can finally share our experience with human blastoids. Beautiful morphology but EPES cells have limitations in lineage specification. Reconstructing aspects of human embryogenesis with pluripotent stem cells | Nature Communications https://t.co/UIslKNLHDp

[Human Blastoid @humanblastoid]

"to form high-fidelity embryo models, gathering a community comprising stem cell biologists, embryologists, synthetic biologists, computational biologists, physicists, engineers, and ethicists will be key"
https://t.co/JbnybazJ5c
#TeamScience

[Human Blastoid @humanblastoid]

Exciting special issue @CellStemCell of stem cell-based models of (human) embryos, including #HumanBlastoid models:
1 commentary, 4 perspectives, 5 reviews, and orginal research reports, articles and resources

https://t.co/K8WbcJ9nvW

[Fredrik Lanner @fredrik_lanner]

Interested in embryo models, have a look at this today’s focus issue of Stem Cell Reports edited by ⁦@fu_jianping⁩ and ⁦⁦@NRivron⁩ . Don’t miss our review written together with ⁦@EPosfai⁩ ⁦@HGLeitch⁩ ⁦@C_Mulas⁩ https://t.co/w12yHyaCog

[Nature Methods @naturemethods]

Research Highlight by @madhuramukho:

The teams of @leo_jwu at @UTSWNews and Jose Polo at @MonashUni have independently developed different methods to generate the first human blastocyst-like structures in vitro. Both published in @nature.

https://t.co/qav6YmOp0X

[Human Blastoid @humanblastoid]

@fredrik_lanner @ChengZh71215605 Thank you

[Human Blastoid @humanblastoid]

@fredrik_lanner @ChengZh71215605 Is this available for analysis?

[Gert Jan C. Veenstra @GJCVeenstra]

After the mouse blastoid in 2018,
... this is the year of the #HumanBlastoid

It is exciting to see a new field take off

This one will open up early human development for analysis using stem cell-based embryo models

[Human Blastoid @humanblastoid]

Paper #5 in the burgeoning human blastoid field:
- New protocol for making embryo models from naive stem cells
- Paper reports some improvements in efficiency and quality

https://t.co/1KTm6PaAdX

[Human Blastoid @humanblastoid]

@E_Vrij a truly #humanblastoid with a healthy dose of tiger umpf

[Sebastiaan Mastenbroek @S_Mastenbroek]

Het is wetenschappers gelukt de ontwikkeling van embryo's na te bootsen. De gevolgen op lange termijn kunnen groot zijn. https://t.co/I1K3ZGpy8q via @trouw @amsterdamumc

[Human Blastoid @humanblastoid]

@leo_jwu @MonashUni Congratulations. Beautiful cover!
#humanblastoid

[Human Blastoid @humanblastoid]

Question answered: One year and five months it was

[Jun Wu Lab @leo_jwu]

We are excited to share our work on human blastoids as a model of pre- and peri-implantation human development (@leo_jwu, @hon_lab, @leqianyu, @Yyyyyy1005，@jlduan).
Article: https://t.co/eVsABEPCES News and Views: https://t.co/cCjMPlY2lU (1/10)

[Rene Fransen @Fransen_R]

Morgen (hopelijk, als er plek is) mijn bericht hierover in @ndnl Met reactie van @GJCVeenstra

[Human Blastoid @humanblastoid]

Research into embryo-like structures should come with adequate ethical and societal reflection
This is important: We need to make steps to solve fertility problems and congenital disease
We need to understand the biology of our own ontogeny
It is time
8/8

[Human Blastoid @humanblastoid]

This week, a major breakthrough for human developmental biology
Today, two papers on human stem cell-derived embryo models (#HumanBlastoid), are published in Nature
Last week, two other manuscripts were posted on bioRxiv

This is a game changer for the field
A thread
1/8

[Human Blastoid @humanblastoid]

Blastoids are the future for human developmental biology
#JoinTheClub
The SteMBlast consortium aims to develop, optimize, investigate stem cell-based embryo models and use them for basic, translational and pre-clinical research of human development and fertility
@ZonMw
7/8