Dorentina Humolli

PhD student at @ETH_en studying phage-host interactions

[Alexander Harms @AHarms485]

🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.

Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.

A thread 1/8

[Dorentina Humolli @humolli_d]

And big thanks to all co-authors Jessica Ransome, Damien Piel, @JWVeening for their amazing contributions!

[Dorentina Humolli @humolli_d]

🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years at @ETH_en! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)

[Dorentina Humolli @humolli_d]

It has been a great journey so far and I can't wait to see the viral dark matter that will get turned into functional insight using HIDEN-SEQ. Huge thanks to @AHarms485 who made this work possible. It has been a privilege to tackle something this ambitious together.

[Nicholas M. I. Taylor Lab @NMITaylorLab]

Very happy our paper on Zorya anti-phage defense system is now published in
@Nature! 🥳 Big congrats to first authors
@HaidaiHu and @__jphilipp and all other authors! Wonderful collab with @Salmo_Lab
and @SimonJacksonNZ #cryoEM @UCPH_CPR @koebenhavns_uni https://t.co/AFPSKH14Za

[alex meeske @alexjmeeske]

Many bacteria have >1 CRISPR system, and they affect each other! @shallymarg found a 3-way interaction that leads to primed adaptation in the RNA-targeting type VI system, check it out:

[Alexander Harms @AHarms485]

You are looking for a PostDoc position or know someone who is? We are looking for someone to join our team at @ETH_en Zürich for a project on phage-host interactions of Pseudomonas aeruginosa 🦠🧬👇🏼

[Dorentina Humolli @humolli_d]

Exciting news! More diversity added to the BASEL phage collection 🧬. Check out the preprint 👇

[Alexander Harms @AHarms485]

Preprint alert 🚨! I present you the second and final manuscript on the BASEL phages! 36 new deeply characterized phages from viral groups that were so far mostly terra incognita - and all infect the E. coli K12 lab strain with easy tricks. 1/12
https://t.co/lqZdYvMkSG

[Jörg Vogel @JoergLab]

I am glad I can finally share this:

Non-genetic mRNA silencing reveals essential genes in phage-host interplay.

Enabled discovery of new important genes of Pseudomonas jumbo phage phiKZ.
Also works for defense systems, clinical isolates.

Read here: https://t.co/3iehXZHIXl

[Alexander Harms @AHarms485]

If you are in the area next Monday and curious about molecular phage biology, join us for my inaugural lecture at @ETH_en Zürich - it's public! 🧬🦠👇🏼

[Michael Baym @baym]

Truly excited to see our latest article, in which we were surprised how phages that target conjugative plasmids are both so common and diverse, published!

A real tour de force from @nquinoneso and @implosian

https://t.co/hCZJpzJism

[Mark O. Martin @markowenmartin]

Always makes me think of the night sky.