Hunter Jackson

trained as a mathematician, learning to be more. work in biotech, fractional owner @dolphinsfc

[Sergiu P. Pasca @Sergiu_P_Pasca]

Today in @Nature, we report a new approach to studying human brain development and modeling disease in vivo.

Human neural #assembloids and #organoids have opened new ways to study development in vitro, but they also have important limitations. Transplantation can provide a more physiological environment, yet human cortical cells then develop within a rodent brain that matures much faster, constraining their growth and integration.

To address some of these limitations and obtain more advanced functional readouts relevant to disease biology, we generated #apallial mice, in which ~98% of the cortex and hippocampus fail to form, creating space for transplanted human cortical organoids to grow and integrate extensively.

We call these #xenocortical mice (XCX).

Nearly 7 years in the making. Congratulations to an extraordinary team and wonderful collaborators!

Link to the article below 👇

[Hunter Jackson @hunterj757]

@Romy_Holland I love how you parsed this and left thinking you had an original thought

[Samuel Hume @DrSamuelBHume]

How immunotherapy transformed survival in advanced melanoma

[Hunter Jackson @hunterj757]

@ericrennerbrown very well said, NFA

[Alex Harding @AlexHarding7]

Antibodies are simply not the right modality for tau, which primarily causes its pathology within the cell.

[Hunter Jackson @hunterj757]

@FDuffyNFL deal, see you Sunday night

[Hunter Jackson @hunterj757]

@RapSheet demon Carter back for mahomes next week

[Hunter Jackson @hunterj757]

@TingZhaoPathdoc @MGBpathology @MGHPathology Giant cell urothelial carcinoma

[Hunter Jackson @hunterj757]

@EaglesXsandOs @BrettKollmann totally transformative team building strategy to negotiate on a 100k rookie guarantee for a late round pick

[Hunter Jackson @hunterj757]

@EaglesXsandOs @Flynn_tj @BrettKollmann not really, it refers to harvesting second+ order stats to enhance team building on a limited budget, which is the exact opposite of what the eagles do.

[Hunter Jackson @hunterj757]

@EaglesXsandOs @Flynn_tj @BrettKollmann this is not unique, they are not balling on a budget like the moneyball A's were. the process 6ers wasn't moneyball either - the eagles identify market inefficiencies and capitalize better than anyone, which is dynamic YOY and they are uniquely good at it.

[Hunter Jackson @hunterj757]

@Flynn_tj @EaglesXsandOs @BrettKollmann my point is that the eagles aren’t playing money ball bc they’re not squeezing value off analytics on a severely limited budget in an uncapped league. They are clever in cap flexibility, pay top of market if deserved, and found that elite talent on O/young&cheap D is the way

[Hunter Jackson @hunterj757]

@EaglesXsandOs @BrettKollmann every example you gave is an expiring contract where the team is demanding a restructure or release, its not a player with leverage choosing to take less for the benefit of the team. I’m not debating that howie is good at cap, I’m telling you he’s not dealing w same restraints

[Hunter Jackson @hunterj757]

@EaglesXsandOs @BrettKollmann I would hardly argue cap manipulation with effectively infinite cash is equivalent to dealing with cash limitations in uncapped league a la money ball. Also, name a vet that has taken a pay cut. It’s exactly the opposite of that, eagles reward early and often.

[Hunter Jackson @hunterj757]

@fashion_nfl eagles, bucs, rams

[Hunter Jackson @hunterj757]

Memory forms through DNA breaks AND repair. Potential to enhance memory durability by targeting IFN signaling through microglial cells and/or DNA repair enzymes. New targets for immune mediated inflammatory diseases and neurodegen:

https://t.co/InD8w5d2bE

[Hunter Jackson @hunterj757]

On-Demand CRISPR formula for success

1. Single-point liver(!) mutation targeted w/ bespoke m/gRNA delivered via lipid nanoparticles
2. Infant w/out antibodies to Cas9/LNPs
3. FDA compassionate use (7 weeks design to dose) due to urgent clinical risk
https://t.co/I9bfcALKQY

[Hunter Jackson @hunterj757]

@LnrdRizzo @Unibocconi this was published same day, time stamps?