Ian Thompson

PhD Student @stanford | Excited about biosensing, diagnostics, aptamers and more | he/him 🇨🇦

[Ian Thompson @ianapt1]

@glembockyte Congratulations!! It was great to hear more about this work at FNANO and I'm excited to see it out in the world!!

[Ian Thompson @ianapt1]

@LabNetz Good point, lots of fundamental learning to be done even for the most common proteins, since nobody has ever studied them continuously. The future of this technology is exciting!

[Ian Thompson @ianapt1]

@LabNetz This is awesome work! I really like the insulin/inulin example - it's incredibly illustrative.

Are there targets that stick out to you as the best first use cases for ISF protein sensors? Seems like they need to be high abundance and simple partitioning/biology... Maybe CRP?

[Ian Thompson @ianapt1]

If you want to know more, check out the article or this more accessible summary of what motivated us and what we learned:
https://t.co/4v2a9qlqBB

[Ian Thompson @ianapt1]

Biomedical engineers dream of less invasive ways to monitor our health - could skin be the answer?
We take on this question in our new collaborative perspective article on dermal interstitial fluid (ISF) and its future in diagnostics and biosensors!

[Nature Biomedical Engineering @natBME]

Opportunities and challenges in the diagnostic utility of dermal interstitial fluid

https://t.co/eaCqljhILk

[Ian Thompson @ianapt1]

5/5 Where do we see this tech making the most impact?

Short term: Therapeutic drug monitoring to optimize how we dose drugs while avoiding side effects.

Long term: General health and immune monitoring to catch the early warning signs of disease.

[Ian Thompson @ianapt1]

But most of all, it was just really fun to get to exercise some of our underutilized electrical engineer muscles (including fourier analysis!), and to work with an awesome team with @nmaganz @brandwilso @HTSohLab

[Ian Thompson @ianapt1]

#biosensors Twitter! Sensing both sensitivity and FAST is a huge challenge because of a fundamental limit for real-time sensors. Higher affinity -> slower receptor off-rate -> slower sensor ⏳!

Here's our attempt at tipping the scales!
(led by @nmaganz) https://t.co/XF8tdfrxAm

[Ian Thompson @ianapt1]

There are also some very cool insights in the paper:
An algorithmic way to sense fast with a slow receptor with proof of concept data.
Counterintuitive rules to optimize receptors for real-time sensing (higher affinity is not [always] better).

[Ian Thompson @ianapt1]

It was so amazing to be back in-person at the Bioanalytical Sensors GRC! Lots of great people and great science. Now looking forward to co-chairing the affiliated 2024 GRS with @Dshekemi

Plus a very serendipitous 42-hour layover spent at the beach in Toronto!

[Ian Thompson @ianapt1]

Incredibly exciting news!! Congratulations @AmaniHariri20 🎉🎉🎉

[UBC Chemistry @UBCChem]

The Dept of Chemistry is pleased to announce the appointment of Dr. Amani Hariri as an Assistant Professor in the area of biological chemistry with a focus on biosensing. She will join the department January 1st , 2023. Read more about Dr. Hariri here: https://t.co/wcox25WbKQ

[Stanford University @Stanford]

A new device can continuously sense levels of virtually any protein or molecule in the blood. Researchers say it could be transformative for disease detection, patient monitoring and biomedical research. https://t.co/IHvckgM0I4

[Das Lab @RDasLab]

Are you programmer looking to contribute to ongoing mRNA vaccine development? The Das Lab is looking for a fast and detail-oriented programmer to quickly re-code existing dynamic programing methods for mRNA vaccine stabilization. Please DM us if interested!

Details in thread:

[Ian Thompson @ianapt1]

Really excited for this review! #aptamer switches offer so many interesting, programmable functions for nanotechnology. It's great to have this whole body of work collected in one article.

[The Soh Lab @ Stanford @HTSohLab]

Want to learn more about the ongoing progress in programming functional responses into aptamers for the design of stimulus‐responsive nanomaterials? Check out this review from our lab by Alex Rangel and @AmaniHariri20 in Advanced Materials!
https://t.co/98A8RRgMQ1