@LabNetz Good point, lots of fundamental learning to be done even for the most common proteins, since nobody has ever studied them continuously. The future of this technology is exciting!
@LabNetz This is awesome work! I really like the insulin/inulin example - it's incredibly illustrative.
Are there targets that stick out to you as the best first use cases for ISF protein sensors? Seems like they need to be high abundance and simple partitioning/biology... Maybe CRP?
Biomedical engineers dream of less invasive ways to monitor our health - could skin be the answer?
We take on this question in our new collaborative perspective article on dermal interstitial fluid (ISF) and its future in diagnostics and biosensors!
5/5 Where do we see this tech making the most impact?
Short term: Therapeutic drug monitoring to optimize how we dose drugs while avoiding side effects.
Long term: General health and immune monitoring to catch the early warning signs of disease.
But most of all, it was just really fun to get to exercise some of our underutilized electrical engineer muscles (including fourier analysis!), and to work with an awesome team with @nmaganz@brandwilso@HTSohLab
#biosensors Twitter! Sensing both sensitivity and FAST is a huge challenge because of a fundamental limit for real-time sensors. Higher affinity -> slower receptor off-rate -> slower sensor β³!
Here's our attempt at tipping the scales!
(led by @nmaganz) https://t.co/XF8tdfrxAm
There are also some very cool insights in the paper:
An algorithmic way to sense fast with a slow receptor with proof of concept data.
Counterintuitive rules to optimize receptors for real-time sensing (higher affinity is not [always] better).
It was so amazing to be back in-person at the Bioanalytical Sensors GRC! Lots of great people and great science. Now looking forward to co-chairing the affiliated 2024 GRS with @Dshekemi
Plus a very serendipitous 42-hour layover spent at the beach in Toronto!
The Dept of Chemistry is pleased to announce the appointment of Dr. Amani Hariri as an Assistant Professor in the area of biological chemistry with a focus on biosensing. She will join the department January 1st , 2023. Read more about Dr. Hariri here: https://t.co/wcox25WbKQ
A new device can continuously sense levels of virtually any protein or molecule in the blood. Researchers say it could be transformative for disease detection, patient monitoring and biomedical research. https://t.co/IHvckgM0I4
Are you programmer looking to contribute to ongoing mRNA vaccine development? The Das Lab is looking for a fast and detail-oriented programmer to quickly re-code existing dynamic programing methods for mRNA vaccine stabilization. Please DM us if interested!
Details in thread:
Really excited for this review! #aptamer switches offer so many interesting, programmable functions for nanotechnology. It's great to have this whole body of work collected in one article.
Want to learn more about the ongoing progress in programming functional responses into aptamers for the design of stimulusβresponsive nanomaterials? Check out this review from our lab by Alex Rangel and @AmaniHariri20 in Advanced Materials!
https://t.co/98A8RRgMQ1