Temporal Proteomic Assessment of Glomerular FAT1 in De Novo Membranous Nephropathy of the Kidney Allograft - Kidney International Reports https://t.co/YMHO93cKem
Good work here by @IbrahimBatal9 in collaboration with our Mayo proteomic core and @MayoClinicPath.
FAT1 is a target antigen in a subset of de novo allograft membranous nephropathy associated with antibody mediated rejection. #MayoClinicKidney@SethiRenalPath@fervenzafernan1 https://t.co/w4NxDXAOfH.
@FridaRosenblum@sam_albadri There is no magic time. Typically a few daybut depending on the injury and sloughing of the endothelium thrombi can persist for longer especially if patient on CNI. Early AMR would be less favored of DSA is negative pretransplant and C4d is neg. Important to rule out ongoing TMA
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@RajguptaEM Interestingly we found that glomerulitis and high proteinuria are associated with worse prognosis in primary MN in the allograft (your pt have both plus low albumin). The glomerulitis in this case may not reflect AMR but stasis and may need to rule out renal vein thrombosis
@RajguptaEM Although no one will know for sure my impression is that AMR associated MGN is weak here for a few reasons: PLA2r is pos, DSA neg, C4d neg and ptc0-1 (none of these reasons by itself is definitive but the combination argues against this possibility). It is likely primary MN