AgingandBrainCancer

#Neurosurgeon treating #braintumors. Father of twins. Dedicated to help #patients w/ BTs by #surgery and #nextgeneration #therapydevelopment by #research.

[Christos Tolias @NeurosurgTolias]

Hypertonic Saline is Superior to Mannitol for the Combined Effect on Intracranial Pressure and Cerebral Perfusion Pressure Burdens in Patients With Severe Traumatic Brain Injury | Neurosurgery | Oxford Academic https://t.co/akQwgrPGaY

[eLife - the journal @eLife]

The Reviewing Editor said that this manuscript by Muhlheip et al. was a "beautifully executed piece of work" https://t.co/pNfUemd812 #fromthedecisionletter

[Cell Metabolism @Cell_Metabolism]

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention https://t.co/FiXuto2Bh6

[bioRxiv @biorxivpreprint]

A genome-wide Approximate Bayesian Computation approach suggests only limited numbers of soft sweeps in humans over the last 100,000 years https://t.co/lncBnBifax #bioRxiv

[Nature Medicine @NatureMedicine]

Genetic analysis of paternal sperm from families with a child affected by #autism reveals that the recurrent risk for transmitting disease-associated de novo mutations to future offspring is near 0% for most couples | https://t.co/FIb1hLcyyQ | @sebatlab @radychildrens

[HHMI @hhmi_science]

Congrats to HHMI's Lily and Yuh-Nung Jan, recipients of the 2019 Perl-UNC Neuroscience Prize for the "discovery and functional characterization of potassium channels." https://t.co/XLxIxP63ts

[EMBL @embl]

Faster, cheaper and more detailed

Researchers at EMBL & the Center for Bioinformatics at Saarland University in Saarbrücken develop a cheaper & faster method to check for genetic differences in individual cells: https://t.co/7Czy3tIzcd

[bioRxiv @biorxivpreprint]

SCSA: a cell type annotation tool for single-cell RNA-seq data https://t.co/XVE67X7bbo #bioRxiv

[Maria Mihaylova @MariaMMihaylova]

Some beautiful (and festive) mito images in the crypt from a graduate student in our lab using Lattice SIM.

[Johns Hopkins Medicine @HopkinsMedicine]

A study suggests lower serotonin transporters may be drivers of #Alzheimers disease. https://t.co/z5uHop7beQ

[Nature Neuroscience @NatureNeuro]

Rather than constraining mnemonic processing, potentiation of somatostatin-expressing (SOM+) #interneurons in medial prefrontal cortex (#mPFC) represents an important causal mechanism for conditioned fear in male mice https://t.co/RmMBIBCL3E

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

New research in @nature from @SJMorrison_ & @RJDLab demonstrates metabolic differences among melanoma cells confer differences in metastatic potential. The findings suggest a therapeutic approach that could reduce disease progression. https://t.co/BG88pJxIS0 @HHMINEWS @UTSWNews

[Alain Chédotal @AlainChedotal]

Inactivation of the primary cilia proteins Arl13b and Inpp5e, linked to Joubert syndrome perturbs #commissure development. Abnormal corpus callosum, corticospinal tract and deep cerebellar nuclei projections. Altered growth cone dynamics and branching.
https://t.co/LpRwdtkiT7

[Anton Henssen @anton_gh]

Check out our paper, online today @NatureGenet ! With Richard Koche @sloan_kettering , @eliasrfos from the Torrents lab @BSC_CNS and colleagues @ChariteBerlin @MDC_Berlin, we describe that circular DNA serves as a substrate for oncogenic genome remodelling https://t.co/BV5sQaXA0r

[David Sinclair @davidasinclair]

Wow! A robust, real-time NAD biosensor. NAD promotes our cellular defenses against deterioration but NAD assays aren’t cheap. This could change all that. Imagine point-of-care devices & skin patch sensors 🚀 https://t.co/p8PGrAfXHM #biohacking #aging #healthandwellness #longevity

[Kentsis Research Group @KentsisResearch]

What is this? Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income https://t.co/SKk8iGHcWN

[Nature Neuroscience @NatureNeuro]

Metabolism of #dopamine by monoamine oxidase (MAO) leads to mitochondrial electron transport chain (ETC) activity, helping to support the bioenergetic demands of phasic release https://t.co/NPFkJ0nL50

[bioRxiv Genomics @biorxiv_genomic]

Single nucleus multi-omics links human cortical cell regulatory genome diversity to disease risk variants https://t.co/3csfIHZMUA #biorxiv_genomic

[Cell @CellCellPress]

Resource in this issue of Cell: Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body - https://t.co/uJCf2YfIsX

[Molecular Cell @MolecularCell]

Online Now: Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores https://t.co/VfXAsd6XIm