Jonathan Sebat

From DNA to the brain. Occasionaly fatherhood, cycling, indie rock. No, Dad will not turn his music down.

[Jonathan Sebat @sebatlab]

I'm pleased to share our latest preprint: Combinatorial effects of gene dosage, polygenic background and environment on complex traits 🧵https://t.co/KBpAJXm6nn

[Jonathan Sebat @sebatlab]

@brainaddiction 🐀 😂

[Jonathan Sebat @sebatlab]

I'm preparing a new talk. Here's one slide that I'm particularly proud of

[Jonathan Sebat @sebatlab]

@NovaSportsReal that estimate might be on the high side

[Nuno Carvalho @nunorgcarvalho]

New [Souaiaia et al. 2026 Nature] paper argues that there is "distinct genetic architecture in the tails of complex traits". Some of my thoughts:

I'm not a fan of framing traits as having distinct architectures at the extremes when it's not really what's going on

[Jonathan Sebat @sebatlab]

@effatma I prefer to be addressed based on my FTP. Jonathan Sebat 3.9 watts/kg

[Jonathan Sebat @sebatlab]

B.S. MDs are the only people I know who are addressed as “doctor” by their co-workers. I know very few academic scientists who refer to themselves or their colleagues by their credentials. “Dr.” is used mainly as formal way of addressing someone who you have just met.

[Dr. Priyam Bordoloi @DocPriyamMD]

Medical Doctors: Hey, I'm the cardiologist keeping you alive, just call me Alex.

PhDs: Please refer to me as Dr. Monica, I did my thesis on ancient pottery.

Look, I know the word 'Doctor' comes from the Latin docere (to teach). I know academics had the title first and I have full respect for the grind. But why are they always the ones defending the title like their lives depend on it?

If someone screams "Is there a doctor on the plane?!" absolutely nobody is looking for a Doctor of Philosophy

[PGC Consortium @PGCgenetics]

1/ We conclude this Twitter takeover spotlighting an upcoming symposium at #WCPG2026
“Advancing Psychiatric Genomics through Large-Scale African Cohorts” 🌍🧬
The session will highlight how African cohorts are reshaping psychiatric genetics globally
@MLCampbell @rockyestroud2

[Jonathan Sebat @sebatlab]

Trigger warning. Today's Press Play with @TheMadBrand is not suitable for parents that are still recovering from PBSSD (Post Baby-Shark Stress Disorder). My youngest is now a freshman in college and I'm still recovering from that earworm.

[PGC Consortium @PGCgenetics]

Take a look at the “Behind-the-Scenes Journey” from the Editorial on Challenges and Strategic Insights of the DepGenAfrica study @depgenafrica as provided by @PGC_Africa’s Comm’s rep @jaredgmaina and colleagues 🛠️🚀
https://t.co/vKfZkR5SGS

[Maria Chahrour @MariaChahrour]

Join us this July at the inaugural Gordon Conference on Neural Genetics and Epigenetics! We’re excited to bring together researchers across neuroscience, genetics, and epigenetics for an exciting lineup. #genetics #epigenetics #neuroscience

[PGC Consortium @PGCgenetics]

Hello from the PGC Africa working group 👋 Today, we begin our takeover to share with you exciting happenings from the working group and its members🎉This takeover is proudly brought to you by @PGC_Africa Africa Comms and Outreach team. Stay tuned!

[Jonathan Sebat @sebatlab]

@autismgadfly autism is also genetically correlated with high IQ

[Jonathan Sebat @sebatlab]

@razoralign How come I can never have cool names like that for our methods

[Jonathan Sebat @sebatlab]

@tonygill3 @MariaChahrour

[Jonathan Sebat @sebatlab]

A very nice commentary from @MariaChahrour on new studies on long read sequencing including ours. 🙂

[Cell Genomics @CellGenomics]

Illuminating hidden genetic architecture in autism https://t.co/9MxMe26KXZ

[Jonathan Sebat @sebatlab]

@girishkaitholil @MariaChahrour Yes some of the missing rare variant contributions are SVs and especially TRs that are not captured well by short reads. Equally important though is inferring the functional consequence of variants that were already detected by SR-WGS but could not be assembled end to end

[Jonathan Sebat @sebatlab]

@Helena_LB Yeah usually the channel the driver was listening to originally is better than the one they change it to when they pick up suburban white people. I guess they only hear from the people that complain

[Jonathan Sebat @sebatlab]

Every lab has a secret weapon. Be that weapon

[Matt Smethurst @MattSmethurst]

A news reporter asked Michael Jordan if he thought the ’90s Bulls could beat LeBron’s Lakers.

MJ: Yes.
Reporter: By how much?
MJ: Two or three points.
Reporter: Why so close?
MJ: Most of us are almost 60 now.

[Jonathan Sebat @sebatlab]

Maybe I won’t need to do lengthy Twitter threads about my own papers if I can trick @doctorveera into doing them 🤔