We study host-bacteria interactions using Listeria and MS-based Proteomics with a focus on Ubiquitin-like modifications (e.g. ISG15) and MHC complex peptides.
🚀 Boosting bacterial immunopeptide discovery! Our bioinformatics workflow integrates 4 search engines with follow-up rescoring to enhance ID by 27%, maximizing the discovery of vaccine candidates. Applied to timsTOF/Thermo data🦠💉 @ImpensLab
🔗Read: https://t.co/QnimRF5XQQ
Happy to share our immunopeptidomics pipeline using four search engine with follow-up rescoring to boost confident IDs. Also applied to timsTOF SCP data!
@ImpensLab@compomics
Preprint: https://t.co/QwrAI9J3cP
Excited to share our latest MCP article uncovering > 6,000 MHC class I immunopeptides in Listeria-infected mice, including 12 Listeria peptides and a potent CD8+ T cell epitope. Many thanks to all co-authors for the excellent work! Read more at https://t.co/d67VbVn5hc
Meet SlyB, a lipoprotein that forms stress-induced #lipidraft in the bacterial outer membrane.
Off the hands of the great @ArneJanssens95 and @nguyenson85, in collaboration with @JFClab@ImpensLab and Alex Pak lab.
@structbiolbxl @BECM_VIB
https://t.co/JEtRs0wgiM
👏Congratulations to @kkariko & @weissmanlab on becoming #NobelPrize laureates. A lifetime achievement celebrating their important research on #mRNA technology in vaccines.
🤔Did you know VIB, together with @VUBrussel, @ugent and participation of several international institutes helped establish the #BAXERNA consortium to further explore the potential of mRNA vaccines?
We are looking for a #postdoc position in #immunopeptidomics @ VIB & UGent with proteomics/peptidomics expertise to develop novel antibacterial #vaccines, see https://t.co/JvEuYiKHSk. A warm call to proteomics postdocs to apply!
Research on #Moyamoya disease @ImpensLab: "Rare diseases result from dysregulated, often yet unknown molecular pathways. Investigating these conditions can lead to groundbreaking fundamental discoveries while opening treatment options for the patients."
🎊 More wonderful @ERC_Research news! @ImpensLab has received an #ERC Consolidator grant for his research on #Moyamoya disease (#MMD). With this grant, the Impens Lab hopes to provide unprecedented insight into MMD-related immune responses! 👉 https://t.co/2iqIVzJ4zq