Integrative Neuroscience of Cognition and Aging

PI: Taylor W. Schmitz (@taylorwschmitz). Unofficial cholinergic system fan club. @WesternU

[Integrative Neuroscience of Cognition and Aging @inca_lab]

4/4 Our findings reveal that biophysical constraints lead certain BF cholinergic neurons to exhibit greater modularity, while others show greater diffusivity in their functional integration with cortical targets

[Integrative Neuroscience of Cognition and Aging @inca_lab]

https://t.co/tDlxPZxn8M Work led by @Sudesna18, @RoyHaast, Kate Onuska and Prabesh Kanel from @neuroak, @inca_lab, and @UMichRadiology investigating the structure-function organization of basal forebrain cholinergic projection neurons using multimodal neuroimaging is now out in @NatureComms

[Integrative Neuroscience of Cognition and Aging @inca_lab]

3/4 🧬Evidence from both mouse and human data suggests that the BF structure-function gradient is shaped by a tradeoff between the complexity of cholinergic neuron branching and the distance they travel to their cortical targets.

[Nature Portfolio @NaturePortfolio]

A paper in @NatureMedicine reports that a phase 2a trial of drug candidate LM11A-31 in mild to moderate Alzheimer disease suggests that p75 neurotrophin receptor modulation is safe and attenuates measures of degeneration. https://t.co/KdFWz5KfFK

[Nature Medicine @NatureMedicine]

A phase 1 trial of a p75 #neurotrophin receptor, LM11A-31, in mild to moderate #Alzheimers disease suggests that p75 modulation is safe and attenuates measures of degeneration. #p75NTR @hayleyrcshanks @inca_lab @taylorwschmitz @WesternU
https://t.co/H8C9e87q6h

[Integrative Neuroscience of Cognition and Aging @inca_lab]

4/4 Despite the relatively short 26-week duration of the trial, we demonstrate that LM11A-31 slowed disease progression on markers of synaptic integrity and inflammation in the cerebrospinal fluid, as well as cerebral gray matter (MRI) and glucose metabolism (PET).

[Integrative Neuroscience of Cognition and Aging @inca_lab]

1/4 New paper out from @inca_lab with @hayleyrcshanks taking the pilot seat! https://t.co/Zp6GSabGlI. This is the culmination of a years-long collaboration with Drs. Frank Longo @StanfordMed @FrankLo52652180 and Stephen Massa @UCSFMedicine.

[Integrative Neuroscience of Cognition and Aging @inca_lab]

3/4 The trial met its primary endpoint of safety and tolerability. Our team analyzed the trial’s multiple secondary and exploratory endpoints, which included cerebrospinal fluid, structural magnetic resonance imaging (MRI) and FDG positron emission tomography (PET).

[Phys Pharm @westernuPandP]

Congrats to our own @taylorwschmitz and all other awardees! Western innovators receive Early Researchers Awards - Western News https://t.co/TKah2SqQBm

[Schulich WesternU @SchulichMedDent]

#SchulichMedDent's PhD candidate Hayley Shanks may play for Western's women's football team, but off the field, she's tackling Alzheimer’s disease through her research.

Read more in this story by Makaila Atsonglo. ⤵️

https://t.co/fyEleyuFro

[Integrative Neuroscience of Cognition and Aging @inca_lab]

Each of these reviews has a companion primary research article forthcoming - Stay tuned!

[Integrative Neuroscience of Cognition and Aging @inca_lab]

(part 2) @hayleyrcshanks discusses the p75 neurotrophin receptor as a drug target for promoting neuronal resilience to Alzheimer's disease https://t.co/JoLuoRMDqJ. With collaborators Frank Longo and Stephen Massa @StanfordMed and an assist from @k8onuska.

[Integrative Neuroscience of Cognition and Aging @inca_lab]

@SudesnaC examined the spatial relationship between acetylcholinergic modulation and attention in the human cortex using meta-analytic strategies targeting both pharmacological and non-pharmacological neuroimaging studies. Thanks @neuroak and @royhaast! https://t.co/2UmkIzOgzb

[Integrative Neuroscience of Cognition and Aging @inca_lab]

Two review papers out from the @inca_lab this week:

[Integrative Neuroscience of Cognition and Aging @inca_lab]

Congratulations Dr. Sudesna Chakraborty @SudesnaC!!! Newly minted PhD! Read about some of Sudesna's work here: https://t.co/Qb22mIfvNF

[Integrative Neuroscience of Cognition and Aging @inca_lab]

Double congratulations to @BahaaldinHelal for successful defense of your Master of Engineering Science and admission to University of Toronto med school!

[Integrative Neuroscience of Cognition and Aging @inca_lab]

@maximoprado presents at #ADPD2023 on development of open science initiatives and cross-species translational platforms for imaging and touchscreen cognitive testing @TouchScreenCog @mouse_bytes