Inge Wortel

computational immunology & biological data science | simple models: wrong but useful | research software | she/her

[Inge Wortel @inge_wortel]

Phagocytes (pink) are often described as "hunting" bacteria (blue, left). Yet this imagery is misleading for bacteria that move rapidly (right). Our work on Listeria invading the gut is now published https://t.co/TFxhtkQE3v, and has only become better after review! 🧵👇

[Inge Wortel @inge_wortel]

Preprint time!🎉
First up: https://t.co/1oiBp3XLlC, a fun collaboration with immunologist&imaging expert Mark Miller @WUSTLmed! @biorxiv_micrbio

We know that many bacteria can move rapidly, but what does that mean for their ability to cause disease? Here's our answer.👇

[1/11]

[Chris D. Jackson @ChrisDJackson]

📢 BREAKING: President Joe Biden just made history by casting his early vote for Vice President Kamala Harris, supporting her bid to become the first female president in U.S. history.

True to form, @POTUS didn’t skip the line – he stood patiently, just like everyone else, to make his voice heard.

Have you cast your vote yet?

[Inge Wortel @inge_wortel]

@SebastienThis That's great, congrats!

[Inge Wortel @inge_wortel]

@K_T_H_V____ The position is to become a PhD student, so you need to have a master's degree to apply. Hope that answers the question!

[Inge Wortel @inge_wortel]

We are looking for two PhD candidates!

We have two projects combining machine learning and simulations to learn more from videos of immune cell movement. The projects are related but each have a different focus.

For details, see: https://t.co/G7yBwjtKLa

[Lorentz Center @lorentzcenter]

A broad CPM community: end-users, researchers and developers of software tools, come together to (re-)evaluate the major hurdles in the field and lay out a roadmap for the next 30 years of CPM research. https://t.co/lqXeHktjkR
@inge_wortel @tisrenk @hirashima0203 @roeland_merks

[AiNed @StichtingAiNed]

Het inzetten van uitzonderlijk AI-talent is belangrijk om de nationale #AI-kennis- en opleidingsbasis te versterken. Het bestuur van AiNed feliciteert dr. @inge_wortel van de @Radboud_Uni dan ook van harte met de toekenning van haar AiNed Fellowship grant! https://t.co/RP517b4ovh

[Reviewer 2 @GrumpyReviewer2]

#AcademicChatter #AcademicTwitter

[Erika Tsingos @tisrenk]

Last year, the cellular Potts model turned 30. 🥳

To look back on 30 years of research, and glimpse forward to the next 30 years we are organizing a @lorentzcenter workshop.

Dates: December 18-22, 2023.
Registration: https://t.co/MAUZq32hKm

Only a few spots left!

[AlessandraCambi @AlessandraCambi]

ImmuNet: A Segmentation-Free Machine Learning Pipeline for Immune Landscape Phenotyping in Tumors by Muliplex Imaging https://t.co/GOmSSyRr3g

[Inge Wortel @inge_wortel]

Very excited about our upcoming
@lorentzcenter
workshop on CPMs in December! Amazing line-up and very diverse topics. Please RT!

More info/register: https://t.co/lZikq7Clq2

Supported by
@NVTBtheobio
@SMB_MathBiology
@ESMTBio
and the Jan van der Hoevenstichting

[Roeland Merks @roeland_merks]

From December 20-24th, we will be organizing a @lorentzcenter workshop on the occasion of >30 years cellular Potts models, since the first publication by @JamesAGlazier1 and François Graner. Please come join us! https://t.co/4a8AAfAlcQ. Please RT!

[Guido Meijer @guido_meijer]

I was watching Lord of the Rings last night and realized there are many parallels with academia!

A thread 🧵👇

[Yuliya Shapovalova @y_shapovalova]

Our institute has five open positions at different levels (assistant/associate/full professors), broadly advertised for computing sciences. Great environment to work in!
https://t.co/Z9cRtfd1Ej

[Inge Wortel @inge_wortel]

We have vacancies for the position of Assistant/Associate/Full Professor at the Institute for Computing and Information Sciences. Great environment, so if this is of interest to you or someone in your network, see: https://t.co/DzFDYD8LWv Feel free to DM me with any questions.

[Roeland Merks @roeland_merks]

Happy to share our latest work on topotaxis, the movement of cells along density gradients. Detailed motility models display stronger topotaxis than more simple active Brownian particles. Work by Leonie van Steijn (drylab), Joeri Wondergem (wetlab), et al. https://t.co/4eKAnS7dcE

[Jason Sheltzer @JSheltzer]

Fascinating new preprint on bioRxiv tackles a whale of a question:

Whales are huge. So why don’t they get a ton of cancers?

https://t.co/z0KjxPUebi

[Kareem Carr, Ph.D. @kareem_carr]

I know a lot of you wanted a technical breakdown of this meme so here it is!

I don't think you will find this level of detail anywhere else so keep reading if you don't want to miss out.

[Inge Wortel @inge_wortel]

This project was a lot of fun to work on. The full model is available here: https://t.co/9sFxMsTJqV (including interactive web app).

Many thanks to the reviewers for pointing out missing links, and to Mark Miller's team (who did a crazy number of new exps for the rebuttal)!
🔚

[Inge Wortel @inge_wortel]

Phagocytes (pink) are often described as "hunting" bacteria (blue, left). Yet this imagery is misleading for bacteria that move rapidly (right). Our work on Listeria invading the gut is now published https://t.co/TFxhtkQE3v, and has only become better after review! 🧵👇

[Inge Wortel @inge_wortel]

Preprint time!🎉
First up: https://t.co/1oiBp3XLlC, a fun collaboration with immunologist&imaging expert Mark Miller @WUSTLmed! @biorxiv_micrbio

We know that many bacteria can move rapidly, but what does that mean for their ability to cause disease? Here's our answer.👇

[1/11]

[Inge Wortel @inge_wortel]

But phagocytes don't *need* to race bacteria, which they can capture by acting like "fly-paper" instead. It may not sound as heroic, but it gets the job done...

So: transcytosing phagocytes might have a protective function in the gut! More work needed, so time will tell...