Ida Lindeman

Postdoc at University of Oslo
Interested in autoimmunity, celiac disease, RA, plasma cells, BCRs, IG polymorphisms and single-cell technologies.

[Ida Lindeman @IdaLindeman]

Thanks to everyone involved in this study!
Aengus Officer, @ctwatson29, @EivindNess, Ludvig Sollid, @UniOslo, @UniOslo_MED, @Oslounivsykehus, NTNU

[Ida Lindeman @IdaLindeman]

🔔Our new PNAS study: Celiac-associated HLA-DQ2.5 doesn’t just present gluten—it preselects naive TCRs that can recognize gluten. HLA risk alleles help wire a disease-relevant T cell repertoire before antigen exposure. #TCR #celiac #HLA #immunology🧵

https://t.co/TMzKqlDyCq

[Ida Lindeman @IdaLindeman]

Our results offer a new angle on genetic risk and pathogenesis in celiac disease. Which other HLA-associated diseases could be affected by skewed naive TCR repertoires?

[Rasmus Iversen @RasmusIv]

Very happy to share our latest preprint, where we address the relationship between systemic and gut IgA. See link below and details in 🧵. Huge thanks to everyone involved!

https://t.co/phzAHdAgpS

[Cell Reports @CellReports]

Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease https://t.co/fSvOisLNBX

[Jorunn Stamnæs @stamnaes]

Tissue proteomics with clinical value in #celiac disease: - https://t.co/rgqD3HyRFO Great work Anette Johansen and thank you collaborators in particular @SandveGeir for expert ML knowledge! @CeliacDotOrg @UniOslo_MED @Coeliac_UK @AGA_Gastro @coliakiforening

[Rasmus Iversen @RasmusIv]

Very happy to share this story on autoreactive B cells in celiac disease together with @IdaLindeman @LeneHoydahl @ChristophAsb @LouiseFRisnes @JCoDiRC. Here, we identify a population of circulating IgA-switched B cells specific to the self-antigen transglutaminase 2 (TG2).

[Rasmus Iversen @RasmusIv]

Very happy to share that our paper on anti-gluten antibodies in celiac disease is out now in @CellReports. The study was led by Chunyan Zhou @JCoDiRC @UniOslo_MED and was a great collaboration with the Buus lab @UCPH_health. Details in 🧵
https://t.co/LWFlCLC1pv

[GreiffLab 💻🔬💊 @victorgreiff]

New work from our @UiO_LifeSci ImmunoLingo convergence environment in which we leverage linguistics to formalize the antibody sequence language. https://t.co/0jvdiC7E5d. Work led by @MaiSpaceHa, @PRobertImmodels, @pandaisikit.
See🧵below by @MaiSpaceHa for details.

[Ida Lindeman @IdaLindeman]

We're looking for an enthusiastic #postdoc to join the Sollid group (https://t.co/MsK4bz5C2i) at the University of Oslo through the #ScientiaFellows program to investigate genetic polymorphisms in adaptive immune receptors. Please share and DM if interested! #postdocjobs #AIRR

[Andreas Lossius @LossiusAndreas]

We used scRNA-seq to assess the combined transcriptome and Ig repertoires of CSF B cells in MS. This revealed a stereotyped B-cell response using IGHV4/IGKV1 in patients carrying certain IGHC alleles! @EurJImmunol #MS https://t.co/8SPa2eR8zM

[Rasmus Iversen @RasmusIv]

Happy to share this story on anti-gluten antibodies in celiac disease. https://t.co/dyOCGam3bA The project was led by Chunyan Zhou @JCoDiRC @UniOslo_MED and is the result of a long-standing collaboration with the Buus lab @uni_copenhagen. Main findings are summarized below.

[GreiffLab 💻🔬💊 @victorgreiff]

Happy to share our work on multi-dimensional comparison of immune repertoires. Amazing work by @cedricrweber. Great collaboration with Xiao Liu, @ReddyLab_ETHZ, @mkuijjer, and, as always, @SandveGeir. Main findings in 🧵. https://t.co/5ID0ttPkeP.

[Mucosal Immunology @MucosalImmunol]

So you ran a single-cell RNA seq experiment...now what? Ludvig Sollid @JCoDiRC and @IdaLindeman reviews single-cell approaches in the investigation of celiac disease: https://t.co/GFoNYKe3uI #Celiac #SingleCell

[GreiffLab 💻🔬💊 @victorgreiff]

We just released CompAIRR – a tool that reduces greatly the longstanding computational bottleneck of identifying shared identical and similar sequences among large sets of immune repertoires. All the details/links are in the thread below. Feedback is very welcome! @airr_community

[GreiffLab 💻🔬💊 @victorgreiff]

Another new preprint! We combined virtually-docked 3D-antibody-antigen binding complexes with an unbiased in silico oracle to explore at unprecedented resolution the principles of ML-based antibody design with respect to affinity, conformational epitope, and developability. 1/2

[Philippe A. Robert @PRobertImmodels]

Happy to share our preprint: "A billion synthetic 3D-antibody-antigen complexes enable unconstrained machine-learning formalized investigation of antibody specificity prediction"
https://t.co/56rffLJfwk
Check out Absolut! database+software to simulate more
https://t.co/Y0LZcIE9VW

[GreiffLab 💻🔬💊 @victorgreiff]

Our review on "Immunoglobulin germline gene variation and its impact on human disease" is out. Great collaboration with @immuno_ivana and Ludvig Sollid @JCoDiRC. @airr_community Link: https://t.co/hmrrq8TRnQ