LSSI Reddy

This is the official twitter account of Prof. Reddy's Laboratory for Systems and Synthetic Immunology (LSSI) at the D-BSSE, ETH Zurich.

[LSSI Reddy @ReddyLab_ETHZ]

We’re excited to present our most recent preprint on bioRxiv “Multimodal single-cell profiling of T cell specificity and reactivity in lung cancer ” https://t.co/xmL6snv7hy

[LSSI Reddy @ReddyLab_ETHZ]

9/9
This study was led by @flobdalabob, @rodrigov87 and @saireddy911.

[LSSI Reddy @ReddyLab_ETHZ]

We’re excited to present our most recent preprint on bioRxiv “Multimodal single-cell profiling of T cell specificity and reactivity in lung cancer ” https://t.co/xmL6snv7hy

[LSSI Reddy @ReddyLab_ETHZ]

8/9
With tumor-reactive TILs being partly in the proliferation cluster, we wondered how their cell states change upon short-term stimulation culture. This showed an increased transition from the resident memory to the proliferative cell state.

[LSSI Reddy @ReddyLab_ETHZ]

We also had the pleasure to present this work at #PEGSeurope and #ICLE.

[LSSI Reddy @ReddyLab_ETHZ]

We're excited to present SpeedingCARs, our most recent paper published by @NatureComms describing an integrated method to engineer CAR T cells using signalling domain shuffling and single-cell sequencing.

https://t.co/eelI1IAtRD

[LSSI Reddy @ReddyLab_ETHZ]

In summary, speedingCARs substantially expands and characterizes the signaling domain combinations suited for CAR design and supports the engineering of the next-generation T cell #immunotherapies.

[D-BSSE, ETH Zurich @ETH_BSSE]

Engineering T-cell receptors for cancer #Immunotherapy |
Read about the foundational technology of the spinoff #EngimmuneTherapeutics, developed by Rodrigo Vazquez-Lombardi, Synthetic Immunology lab led by Sai Reddy @ReddyLab_ETHZ >https://t.co/Xu8kIrRPft
@ImmunityCP

[LSSI Reddy @ReddyLab_ETHZ]

ETH-Zürich (@ETH_en) has put out a great summary of our DML technique and how it can help us develop more effective antibody therapies and vaccines against future variants of SARS-CoV-2. Read more about it here: https://t.co/vmtY2e1OFu

[Cell @CellCellPress]

Now online! Deep Mutational Learning Predicts ACE2 Binding and Antibody Escape to Combinatorial Mutations in the SARS-CoV-2 Receptor Binding Domain https://t.co/QULlnk9Y3x

[LSSI Reddy @ReddyLab_ETHZ]

Update: Our deep mutational learning #DML paper on #SARSCoV2 profiling is now online at @CellCellPress! Now with more in-depth assessments of a greater number of antibodies!

https://t.co/SIh8ltLl2E

[LSSI Reddy @ReddyLab_ETHZ]

It has been 2 years since the 1st detection of #SARSCoV2 and yet the #pandemic shows little signs of slowing down, as seen most recently through the emergence of #omicron and its surprisingly large No. of mutations. How surprising is that though? A thread. https://t.co/G1WPrLxD8f

[LSSI Reddy @ReddyLab_ETHZ]

Great collaborative effort of PostDoc and PhD students from our lab @JosephMTaft @cedricrweber @beichengao @Roy_ehling @AlexYermanos as well as friends from @waikato Dr William Kelton @saireddy911