David Maltz

Advisor and strategist at the intersection of the consumerization of healthcare, medtech development, digital health and wearable/pervasive technology

[Evelio González Prieto @evelio_prieto]

🔘🔴🔘COVID PERSISTENTE: DESREGULACIÓN DEL SISTEMA INMUNITARIO, LA APOPTOSIS Y LAS MITOCONDRIAS, Y SU ASOCIACIÓN CON SÍNTOMAS A LOS 10 MESES
🧵1⃣Artículo de 9 investigadores de centros de Pakistán
https://t.co/mUjdKZonFX

[U.S. Surgeon General @Surgeon_General]

Millions of Americans live with infection-associated chronic conditions and illnesses, including long COVID, ME/CFS, and Lyme disease–associated chronic symptoms; conditions that are often debilitating, misunderstood, and under-recognized.

In a new Clinical Infectious Diseases viewpoint, CAPT Iskander and Dr. Haridopolos of the Office of the U.S. Surgeon General call for making these “invisible illnesses” visible through patient-centered care, stronger surveillance, multidisciplinary management, and continued research investment.

The article emphasizes the importance of validating patients’ lived experiences while advancing evidence-informed care to improve outcomes for people living with these complex chronic conditions.

[Hiroshi Yasuda (保田浩志) @Yash25571056]

As you may already know well, "young patients who experienced a second confirmed SARS-CoV-2 infection during the omicron period were more than twice as likely to receive a clinician-documented diagnosis of post-acute sequelae of COVID-19 (PASC) as those in the same calendar period after a first infection..
[In this cohort study of >465,000 patients younger than 21 years,] the incidence of clinician-documented PASC was roughly 1,884 cases per million children after a second infection, compared with about 904 cases per million after a first infection..
Beyond formal PASC diagnoses, children and adolescents who experienced reinfection had an elevated risk of a wide range of symptoms and conditions previously associated with long COVID.
These outcomes spanned multiple organ systems, including:
- cardiovascular complications such as myocarditis, arrhythmias, heart disease and chest pain;
- neurologic and cognitive effects such as headaches, cognitive impairment, postural orthostatic tachycardia syndrome (POTS) and other forms of dysautonomia;
- kidney injury;
- thrombotic events; and
- more common symptom clusters including fatigue, abdominal pain and musculoskeletal pain.
Myocarditis risk was more than three times higher after a second infection, and the risk of thrombotic events more than doubled..
These findings directly contradict the common assumption that because acute omicron illness is usually mild in children, and reinfection is clinically inconsequential.."

SARS-CoV-2 is different.

'Reinfection raises Long COVID risk in children and adolescents'
https://t.co/5x6y9gNfSq

[PolyBio @polybioRF]

It’s great to see the PolyBio-supported Long COVID tissue bank and LIINC collaborative featured in Men’s Health this week! Collaborating with Dr. Michael Peluso has driven forward PolyBio’s work and the Long COVID field at large. Check out the article 👇🏻

https://t.co/7TgHrxsAEv

[Michael R Scoma MD @DrMichaelScoma]

In ME/CFS, mitochondrial dysfunction is unlikely a primary driver. Chronic autonomic dysfunction with impaired perfusion and REDOX imbalance ▶️ secondary bioenergetic failure. Endoplasmic reticulum stress emerges in parallel, amplifying cellular dysfunction.

[Hiroshi Yasuda (保田浩志) @Yash25571056]

"COVID-19 might be significant to Parkinson’s disease and Alzheimer’s..
The inflammatory response in the brain is the main link between COVID-19 with neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease.. molecular studies indicate similar inflammatory pathways..
deficient gliovascular communication, microglial aberrant activation, reduced endothelial nitric oxide synthase (eNOS) and vascular dysfunction observed in COVID-19 patients and experimental models may contribute, accelerate, or exacerbate neurodegenerative processes..
epidemiological data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) patients demonstrated an increase in cognitive impairment prevalence from 4.3% in pre-COVID-19 to 6.8% in post-COVID-19.."

Our cognitive change has only just begun.

'Neuroinflammation and Oxidative Stress in Parkinson’s Disease, Alzheimer’s Disease, and COVID-19: Microglia–Neutrophil Interaction'
https://t.co/NZgHjiDEZW

[Adam @ABrokenBattery]

A powerful introduction to a parliamentary debate in the Netherlands on post-acute infection syndromes (PAIS), including #LongCOVID, #MECFS, chronic Lyme & post-sepsis conditions.

Dutch MP Kostić describes it as one of the biggest medical scandals of recent decades. (29/1/26)

[David Maltz @intervalent]

This is a very detailed analysis of the power of the metabolic lens on both physical and mental illness. Great read. And thanks for the shout out to https://t.co/WLfSGnZDmQ!

[Tim Ferriss @tferriss]

NEW blog post is up!

"How I Beat Lyme Disease with The Ketogenic Diet — Science, How-To Protocols, and 10+ Years of Zero Symptoms"

I started writing this as a reply to @TheGregYang, co-founder of xAI, who recently stepped down from xAI to address his debilitating case of Lyme disease.

Ultimately, I decided that a blog post could provide more detail and allow proofreading by credible scientists, so here we are.

Before we dive in, a disclaimer: I’m not a doctor, nor do I play one on the internet. The following is for informational purposes only. Please consult with your doctor and read the warnings at the end.

CONTINUE READING:
https://t.co/W2dxiOo3Iu

[Jack | amatica health @JackHadfield14]

Brain scans in ME/CFS and Long COVID have found changes in glutamate and GABA, the chemicals that control brain activity.

Multiple studies now suggest disrupted excitation and inhibition may be linked to brain fog, fatigue, and sensory symptoms. Let’s breakdown in simple terms.

[Putrino Lab @PutrinoLab]

This is a novel, first-in-human #LongCOVID clinical trial. If you're in the New York area (or can travel there), please consider taking part!

[David Maltz @intervalent]

@Alina_MSN_RN @CoRESinai This is the first clinical study with this device technology.

[David Maltz @intervalent]

@SunMoonTzu @CoRESinai @ravenscimaven @PutrinoLab @microbeminded2 @polybioRF @longcovidlabs is a decentralized science org looking into this now. Worth checking out their progress. They just had a successful token offering to fund the org.

[David Maltz @intervalent]

@CoRESinai @Naomi_D_Harvey @TraceyABurgess Note that there are 3 in-person visits, 4 weeks apart. There are 7 short virtual visits as part of the study.

[Amy Proal, PhD @microbeminded2]

As CoRE’s Scientific Director I’m excited about this trial.

#LongCovid patients in NYC: check the flyer to see if you might be eligible!

[David Maltz @intervalent]

#digitaltherapeutics provide a new mechanistic approach to disease treatment that is orthogonal to molecular medicine. This adds not only a new dimension, but the combination of the two magnifies the impact. @EddieMartucci #BiotechShowcase

[Aidar Health @AidarHealth]

We are humbled and honored to join forces with @BARDA to combat #COVID19. Please contact us if you’d like to work with @AidarHealth on this monumental project!@startuphealth @MedTechAwards @_DiMeSociety @DigitalTrends @HHSGov @MDBiz @AmerMedicalAssn @WSJ @forbes @COVID19Tracking

[David Maltz @intervalent]

So impressed with @KateDilligan's confident pitch for at @MedTechAwards finals! Fingers crossed that @coolerheads_ will prevail! Amazing job, Kate!

[David Maltz @intervalent]

This will be really useful to have as a comprehensive yet digestible summary of what the FDA actually does in accessible language. I'll be bookmarking this one and sharing for sure!

[Y Combinator @ycombinator]

YC Bio founders often ask us about the FDA and the broader regulatory environment. @reshmakhilnani and @seehafer touch on some of the most important concepts bio founders should think about and distills them down to their essence.
https://t.co/B5Py2Jq0Ns

[Y Combinator @ycombinator]

YC Bio founders often ask us about the FDA and the broader regulatory environment. @reshmakhilnani and @seehafer touch on some of the most important concepts bio founders should think about and distills them down to their essence.
https://t.co/B5Py2Jq0Ns

[David Maltz @intervalent]

@warriors Man, @BigTicket_JW, that must be frustrating! I'm working with a company @BioIntTech that could help you recover quickly with their #TENZR wrist PT device. As a long-time @warriors fan, I'd love connect you to them. BTW, @rick_celebrini, the company is based in Vancouver!