#HAYA is officially a #Clinical-stage company!
The first cohort has been dosed in our #Phase1 clinical trial evaluating #HTX001, a first-in-class investigational therapy targeting the #lncRNA#WISPER for #nHCM. 🫀
I'm looking forward to seeing folks in sunny Orlando. 😎
I'm really excited to discuss Haya's development candidate & atlas of novel biology; decoding & enabling lung remodelling & rejuvenation by targeting the regulatory genome. 🫁🧬 #RIS2026
🆕 review with @jp_unfried out in @NatureSMB 🧐. Direct roles of lncRNAs in transcriptional activation. What do we understand about how lncRNAs lure Pol2 and set the stage for RNA production, and what do we still miss? https://t.co/iYJQ7Rbb9d
Attending #cshlregRNA next week? 🇺🇸
#HAYA’s Senior Director of Biology and Functional Genomics, Rudi Micheletti, will present our lead program, with an emphasis on the #MoA and precision #ASO targeting of #WISPER, the master lncRNA driving #MyocardialFibrosis.
Let’s connect! 🤝
New preprint of my postdoc work! We found a novel group of zinc-finger proteins that rapidly evolved in a lineage-specific manner to repress regulatory activities of transposon-derived sequences through anchoring nucleosomes.
https://t.co/vwI8BdMrQ9
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Our paper about TE's regulatory functions using ENCODE data has been published! https://t.co/9ngI3POHrc @twang5@CedricFeschotte We confirmed TEs contributed 25% of regulatory elements in the human genome. We also investigated how different TEs contributed differently. /1
💥Our new preprint!
Transposon ADDICTION in development!
Gag proteins of endogenous retroviruses are required for zebrafish development
Study led heroically by @sylviaandbu & @JN_Wells
This work has transformed my view of transposons, no less! 🧵1/n
https://t.co/d1yNgFbBSb