iPVD consortium

#Infection and #pulmonary #vascular diseases consortium promoting researches and education

[NEJM @NEJM]

The prognosis of liver disease depends on the extent of fibrosis, which is usually staged with the use of liver biopsy. The limitations of biopsy have led to the development of noninvasive tests, which Drs. Laurent Castera, Mary E. Rinella, and Emmanuel A. Tsochatzis review. Learn more: https://t.co/oZ93UDdEiA

[William A. Wallace, Ph.D. @WilliamWallace]

How the brain talks to the immune system

This diagram shows the inflammatory reflex - a neural circuit where the brain regulates inflammation through the vagus nerve. It’s how psychological stress, inflammation, and immune activity stay linked.

1️⃣ The signal starts in the brain
The vagus nerve carries electrical impulses from the brainstem to the spleen, the body’s blood-filtering and immune-coordinating organ.
🟢 Example: Deep breathing and meditation can activate the vagus nerve, lowering heart rate and reducing circulating inflammatory markers like CRP and IL-6.

2️⃣ The spleen acts as a relay
When the vagus nerve is stimulated, it triggers the splenic nerve to release noradrenaline, which activates immune T cells to release acetylcholine.
🟢 Example: In animal models, vagus nerve stimulation increased noradrenaline in the spleen within minutes, showing how fast the nervous system can modulate immunity.

3️⃣ Acetylcholine calms inflammation
This neurotransmitter binds to receptors on macrophages, reducing the release of tumor necrosis factor-α (TNF-α), an inflammatory cytokine involved in chronic disease.
🟢 Example: Clinical studies using implanted vagus nerve stimulators in rheumatoid arthritis patients lowered TNF-α levels and improved joint pain without immunosuppressive drugs.

The inflammatory reflex shows that inflammation isn’t just chemical, it’s electrical. The brain can literally tell the immune system when to stand down.

[Ghazwan Butrous @gbutrous]

This is our last article in a special issue we at @iPVDc edited in the "Infectious Diseases Reports"

https://t.co/Z4bUxwYIpk

[The Pulmonary Vascular Research Institute @PVRI]

🌍 Upcoming webinar – free & open to all! Join us for the next session in the iPVD Virtual Symposium Series, where Prashant Bobhate will be discussing 'Pulmonary Hypertension in the Shadow of Infections: Challenges in Indian Practice'.

🗓️ 27 August 2025
⏰ 3PM BST

Moderated by Navneet Dhillon - register for free https://t.co/2ahIOSNlSR

#PVD #PulmonaryHypertension #Infection #Inflammation #Webinar

[Kurt Prins @kurt_prins]

Alternative link: Microbiota Transplant Therapy Is Safe and Feasible in Pulmonary Arterial Hypertension | JACC: Basic to Translational Science.

[Eric Topol @EricTopol]

Here is the long version of the Covid artery story culminating in the report below on vascular aging
https://t.co/ngebvhSlvA

[Unlimit Health @unlimit_health]

We’ve got some top Sunday podcast listening for you!

Dr Bonnie Webster of @SchistoSSR explains how Zanzibar is working to eliminate parasitic diseases such as schistosomiasis and soil-transmitted helminths.

🎧 LISTEN NOW: https://t.co/qCpLGwvvAS

[Navneet Dhillon @nadhillon]

Thrilled to share our recent publication in #ATVB on LncRNA-536, one of the novel drivers of smooth muscle proliferation in Pulmonary hypertension . Grateful to the team for their outstanding work. @aatishmahajan

[TheTruePath @The_Truepath]

This is Thomas Seyfried.

He’s a professor of biology, who’s studied cancer for 30+ years.

His message? Cancer isn’t bad genes or bad luck—it’s damaged mitochondria.

This flips everything you’ve been told about how to treat & prevent cancer:

[Sasha Prisco, MD, PhD @SashaPrisco]

Grateful for the opportunity to put together this review on the role of the gut microbiome & infections on PAH with my amazing colleagues @thenappanMD @ArcSuellen @ImadAlGhouleh . Thanks to the special issue editors @nadhillon @gbutrous & Dr. Oliveira.
https://t.co/Vxo9AnrOQW

[Suellen D`Arc Oliveira @ArcSuellen]

It was very nice writing this review with amazing peers!

A lot more to uncover in terms of the microbiome in pulmonary arterial hypertension!

New therapies rely on knowledge from both basic, preclinical, and clinical research.

Read more here 👇👇👇

[The Pulmonary Vascular Research Institute @PVRI]

Don’t miss this upcoming iPVD webinar with Yassine Sassi on 'Environmental determinants and PVDs', moderated by Rudolf Oliveira. Free and open to all! https://t.co/bkc4Yw4kA8 #PulmonaryHypertension #iPVD #PVD

[The Pulmonary Vascular Research Institute @PVRI]

Missed Khodr Tello's talk on cardiopulmonary exercise testing in the diagnosis & phenotyping of PH patients at #PVRI2025? Now’s your chance to catch up!🎦

🔹 Current guidelines in regard of cardiopulmonary exercise testing
🔹 Current data in regard of phenotyping PH with exercise
🔹 Outlook to knowledge gaps

Watch the full talk on demand now➡️ https://t.co/gHX8qozQDY #PulmonaryHypertension #Cardiopulmonary #ExerciseTesting

[iPVD consortium @iPVDc]

These are chilling moments.👌

[Collin Rugg @CollinRugg]

NEW: German man escapes de*th thanks to his emergency airbag after being swept away down a mountain by an avalanche.

The incident happened at Mont Blanc, the highest mountain in Europe.

As the man started sliding down the slope, he could be seen inflating his anti-avalanche airbag to keep him above the surface of the snow.

The man was then taken to the hospital by a helicopter.

On the same day, separate avalanches took the lives of five skiers in the French Alps.

Video: leoloux_ on IG.

[iPVD consortium @iPVDc]

I'm looking forward to visiting this library next year when I shall be attending the annual @PVRI World Congress in Dublin from January 29 to January 31, 2026.

[The Library of Trinity College Dublin @tcdlibrary]

Literary greats such as John Banville, Christy Nolan & Eiléan Ní Chuilleanáin feature in the  Long Room exhibition.
Find out more about ‘collecting the now’ for future generations: https://t.co/h62L60x5P6
#NewTreasuresOfTheOldLibrary @tcddublin @TCDResearchColl @BookOfKellsTCD

[iPVD consortium @iPVDc]

Clip from the annual pulmonary vascular diseases infection consortium (iPVD) meeting in Rio de Janeiro, January 29th, 2025. Credit. @nadhillon

[iPVD consortium @iPVDc]

Thank you, Sandra, for a great poster to remember the @iPVDc sessions today at @pvri annual congress.

[Russell Stothard @StothardRuss]

Last year we had some really tremendous MRes and MSc students https://t.co/u3NkU3VzUa who really did shape the global health agenda for schistosomiasis

[The Pulmonary Vascular Research Institute @PVRI]

Happening this week! Register for free https://t.co/NPouP0liCb

[Jason Hong, MD, PhD @jasonhongFC]

Congrats to Adam Brownstein on a great job presenting our ongoing efforts to build a single-cell human lung atlas for PAH at #AHA24! @AdamBrownstein @joeydai @3CPRCouncil