Patrick Irmisch

[Patrick Irmisch @irmisch_p]

@zinnoberblau Well deserved!

[Gintautas Tamulaitis @GTamulaitis]

Enigma of temporal regulation of type III complex activation was solved! We show that retention of the RNA ends provides the molecular memory for maintaining the long activation of the complex for DNA cleavage.
Thanks to Ralf Seidel and Patrick Irmisch for great collaboration!

[Patrick Irmisch @irmisch_p]

@mfwhite2 Thanks! At higher temperatures the complex showed a higher DNase activity but for a shorter duration. I think this due to a faster release of the RNA ends (, which I did not check).

[Patrick Irmisch @irmisch_p]

Super happy to see this work finally out 🎉🎉 Great thanks to our collaborators in Vilnius!

[Juliette Bucci @BucciJuliette]

🎉Our latest work "Timed Pulses in DNA Strand Displacement Reactions" is now out in @J_A_C_S 🧬⏰! Thanks @RicciLab and @erica_delgrosso for your constant support 💪🏻! Another great collaboration with Prof. Seidel and @irmisch_p 🎊! 🙌🏻Check it out: https://t.co/CAuZACec74 📖

[Francesco Ricci Lab @RicciLab]

🥳🥳Just out this week in @J_A_C_S !!! https://t.co/llpbmjAZtT…. In this paper we show how to temporally program pulse output signals in DNA-based strand displacement reactions. Short thread (with gifs) on what we did and how…1/n

[UNIVERSITÄT LEIPZIG @UniLeipzig]

#CRISPR-Genscheren greifen manchmal auch daneben. Um besser zu verstehen, was dabei passiert, haben Forscher:innen der #UniLeipzig um @djk_physics den Prozess auf Nanoebene sichtbar gemacht: https://t.co/gVMsg5k4Zs #Nanotechnologie

[Patrick Irmisch @irmisch_p]

Excited to see this outstanding single-molecule study by Marius Rutkauskas finally published in @NatureComms. Super happy to have contributed to this awesome work!!
https://t.co/jhej7uu2sX

[CRISPRpapers @CRISPR_papers]

A quantitative model for the dynamics of target recognition and off-target rejection by the CRISPR-Cas Cascade complex https://t.co/p6tk052GaM

[J. Am. Chem. Soc. @J_A_C_S]

⏱️ From this week's covers: Temporal control of DNA strand displacement reactions (SDRs) is achieved using blocker strands and specific enzymes.
🔓 Read the #openaccess article from @BucciJuliette @irmisch_p @erica_delgrosso Seidel @RicciLab : https://t.co/okKDovynFj

[Patrick Irmisch @irmisch_p]

@BucciJuliette @J_A_C_S @RicciLab @erica_delgrosso I'm super happy to have contributed to this project. Insane experimental work by @BucciJuliette!!! Congratulations !! 🎉🎉🎉

[Juliette Bucci @BucciJuliette]

I'm thrilled to share that my first 1st-author paper is now online on @J_A_C_S!🎉Come read this new strategy to temporally control DNA-based reactions⏱🧬. Thanks @RicciLab and @erica_delgrosso for your support and Prof. Seidel and @irmisch_p for the great collaboration!💪🏻

[Francesco Ricci Lab @RicciLab]

Finally out in @J_A_C_S our work on enzyme-driven "timers" for DNA strand displacement reactions!⏰🧬⏰🧬⏰🧬⏰. Do you want to control *when* a strand displacement reaction starts? Now you can... short thread if interested on how we did that... https://t.co/L4H1REEvEz 1/6

[J. Am. Chem. Soc. @J_A_C_S]

Orthogonal Enzyme-Driven Timers for DNA Strand Displacement Reactions @RicciLab @UTORV #Enzyme #Strand #DNA #Displacement https://t.co/zZsUwbcPem

[Juliette Bucci @BucciJuliette]

Super happy to share my first 1st-author preprint in @RicciLab! Check it out👇🏻we combine together #DNA and #enzyme to temporally control DNA-based reaction⏱️ 🧬
Great thanks to Prof. Ralf Seidel and @irmisch_p for the collaboration!

[Erica Del Grosso @erica_delgrosso]

Really happy to see my new work in @RicciLab finally published in @angew_chem. Thanks to @SerenaGenti and to @leonard_prins, @ Ralf Seidel and @irmisch_p for the great collaboration! #DNANanotechnology @MSCActions

[Angewandte Chemie @angew_chem]

Dissipative Control over the Toehold-Mediated DNA Strand Displacement Reaction (Ricci) @RicciLab @leonard_prins @UniLeipzig @erica_delgrosso #openaccess thanks to #projektDEAL https://t.co/JjzUNbVmUk

[Nature Portfolio @NaturePortfolio]

A suite of experiments that use the gene-editing tool CRISPR–Cas9 to modify human embryos have revealed how the process can make large, unwanted changes to the genome at or near the target site. https://t.co/WgNTmBQoOA

[Patrick Irmisch @irmisch_p]

@nur_die_bsg wann findet er denn statt?