Samuele Graffiedi

Fisioterapista - Stilton PhD - Maestro di Ciliegi [email protected]

[Samuele Graffiedi @irongrafFT]

"Physiotherapy is about the return of thoughtless, fearless movement" Louis Gifford, 2005

[Samuele Graffiedi @irongrafFT]

Deep Gluteal Syndrome: non è solo il nervo sciatico

https://t.co/WNIo106T4n

[Luca Maestroni @lucamae1987]

"Comparative effectiveness of physical therapy interventions in adults with rotator cuff tendinopathy: a systematic review and network meta-analysis"

https://t.co/BtWNmCRMWl

[Samuele Graffiedi @irongrafFT]

La notalgia parestesica (prurito e fastidio scapolare): revisione della letteratura.

https://t.co/CWZ0DkA6Cz

[Samuele Graffiedi @irongrafFT]

La spalla congelata: lo stato dell’arte.

Grande paper dei colleghi italiani.

https://t.co/U19fABoOD5

[Samuele Graffiedi @irongrafFT]

Spondilartrite nella pratica clinica muscoloscheletrica: screening, sospetto diagnostico e referral.

https://t.co/VLiCuASNxN

[Samuele Graffiedi @irongrafFT]

Di corsi, risotti e co(s)tolette.

[Aakash Gupta @aakashgupta]

The scariest finding in this paper: the subjects couldn't tell it was happening.

UPenn ran this study on 48 healthy adults. One group slept 8 hours. Another slept 6. Another slept 4. For 14 straight days. They tested cognitive performance every 2 hours from 7:30am to 11:30pm.

The 6-hour group's reaction times, working memory, and sustained attention deteriorated on a near-linear curve. By day 14 they were performing at the same level as someone who hadn't slept at all in 48 hours. The 4-hour group hit that threshold by day 6.

Here's the part that should unsettle everyone who thinks they "do fine" on 6 hours: the subjects' self-reported sleepiness flatlined after the first few days. Their brains kept getting worse. Their perception of how impaired they were stopped updating. The cognitive decline was invisible to the person experiencing it.

The researchers found a hard threshold. Any wakefulness beyond 15.84 hours in a day produces cumulative neurobiological cost. That cost compounds every single day you exceed it and does not reset with a weekend of sleeping in.

About 35% of American adults sleep less than 7 hours a night. 40% of those get 6 hours or less. In 1942 that number was 11%. We built an entire professional culture around a sleep schedule that this paper says is functionally equivalent to pulling consecutive all-nighters.

"I'm fine on 6 hours" is the most common response to sleep research. The first thing chronic sleep debt destroys is your ability to notice chronic sleep debt.

[Avi Roy @agingroy]

Aspirin for PRIMARY prevention failed on basically every hypothesis it was tested on. Across ~164,000 patients in meta-analyses: no mortality reduction, unclear stroke benefit, and the number needed to harm (1 in 250 get a major bleed) is actually worse than the number needed to treat (1 in 333 avoid a nonfatal MI).

You're more likely to be harmed than helped.

But the story completely flips for SECONDARY prevention. After a prior heart attack or stroke, aspirin's NNT drops to 50 for preventing another cardiovascular event, with bleeding harm at only 1 in 400. Benefits show up within 2 years.

The problem isn't aspirin. It's giving it to the wrong people.

[ɹǝʇlnoԀ pıʌɐᗡ 🚴🏻 🇺🇸 🇦🇺 🇬🇧 @Retlouping]

Our Contextual effects paper as a video. ⁦@GiacomoRoss86⁩

https://t.co/zbVXDQYqFq

[Samuele Graffiedi @irongrafFT]

😢

[Samuele Graffiedi @irongrafFT]

@DrChrisBishop Many thanks to you and your team!

[Samuele Graffiedi @irongrafFT]

Io Single Leg Squat: quando presciverlo e perché.

https://t.co/HpZjom7WQn

[giorgia. @ehiRicardo]

Mio commento su 17enne che si avvita per aria dopo essere saltato da 50 metri con lo snowboard mentre io inzuppo i biscotti nel latte: "Maaah atterrato un po' seduto sinceramente"

[The Olympic Games @Olympics]

The intensity of the Winter Olympics is here! ❄️🔥

Feel the rush of adrenaline with Alpine Skiing, Cross-Country Skiing, Freestyle Skiing, Luge, Ski Jumping, and Speed Skating. Get ready for the ultimate showdown of speed, skill, and pure passion as athletes push their limits on the world’s biggest stage.

Hurry, the last tickets are almost gone! Don’t miss your chance to witness these thrilling moments live - Link here: https://t.co/Q3lrQFVbaQ 🎟️

#Olympics #MilanoCortina2026 #WinterOlympics

[Samuele Graffiedi @irongrafFT]

Revisione critica dell’utilizzo del ghiaccio negli infortuni sportivi: utile nelle prime sei ore, probabilmente inutile (o dannoso) dopo le prime 12 ore.

https://t.co/EvChKH7Oho

[Samuele Graffiedi @irongrafFT]

Edema spongioso del collo del femore e piccolo trocantere compatibile con Bone Stresa Injury di grado 3 in 🏃‍♀️‍➡️maratoneta.

[Aakash Gupta @aakashgupta]

This is one of the most important studies in sleep science.

Van Dongen et al. ran the experiment that changed how we understand chronic sleep restriction. They had subjects sleep 4h, 6h, or 8h nightly for 14 days, testing cognitive performance every 2 hours.

The 6h group’s reaction time deficits by day 14 matched subjects who had been awake for 24 hours straight. The 4h group? They performed like someone awake 48 hours.

But here’s what makes this study terrifying.

The Stanford Sleepiness Scale ratings in Panel B plateau after day 3-4. Subjects stopped feeling more tired even as their cognitive performance continued deteriorating through day 14. Your subjective experience of fatigue is a lagging indicator that eventually just… stops updating.

This explains why chronic undersleeping feels sustainable. You’ve adapted to feeling tired. Your prefrontal cortex hasn’t adapted to being impaired.

The PVT (Psychomotor Vigilance Task) in Panel A measures lapses in attention. These are the moments where you’re staring at a screen and your brain simply checks out for 500ms. Every additional day of 6h sleep adds more lapses. The curve never flattens.

Panel C and D show working memory and processing speed. Same pattern: continuous degradation with no subjective awareness.

The practical implications:

If you’re sleeping 6h and think you’re functioning fine, you’ve lost the internal calibration to know you’re not. The subjects in this study would have told you they felt “okay” while performing like they’d pulled an all-nighter.

For anyone doing cognitively demanding work, this means you cannot trust how you feel. You need to track objective markers: error rates, decision latency, problem-solving throughput.

Sleep need is biological, not negotiable. Most adults require 7-9 hours, and the research shows no population-level adaptation to chronic restriction. “I only need 6 hours” is almost always “I’ve forgotten what baseline cognition feels like.“

[Samuele Graffiedi @irongrafFT]

Nei pazienti con fascite plantare resistente ai trattamenti (>9 mesi) il release del gastrocnemio mediale prossimale dà risultati simili alla fasciotomia plantare, ma con meno complicanze e guarigione più rapida.

https://t.co/NzfEHj3smM

[Samuele Graffiedi @irongrafFT]

Come interpretare correttamente la significatività statistica (p-value) e l’intervallo di stima.

https://t.co/ECsQe65G0Q

[Samuele Graffiedi @irongrafFT]

Aperto il vaso di Pandora del Leventhal’s Common Sense Model ...
#canofworms

https://t.co/Dcdjlfxj3o

https://t.co/S1UJ8PqU1k