Isabel S

Discovering the molecular biology of CRISPR and exploring life in ATX.

[Isabel S @isabel_stroh]

@DCSwarts @davidwtaylorjr @ut_mbs @TexasScience @MolecularCell @palermo_lab @aakashsahha Thank you!

[David Taylor @davidwtaylorjr]

Awesome updated work by my talented postdoc @isabel_stroh @TexasScience showing Cas12a with the non-target and target strand in the active site! R-loop forms largely in solution. The lid helix appears to reset after each cleavage event. https://t.co/gT5H3hqQJW

[Grace Hibshman @GraceHibshman]

My first story from the @davidwtaylorjr lab is online! I’m looking forward to sharing this research next week alongside @jpkbravo @crispr2023 https://t.co/6IqeP7BM8D

[Isabel S @isabel_stroh]

Looking forward to discussing more things Cas12a, R-loops, and CRISPR next week at @crispr2023 ! 3/3

[Isabel S @isabel_stroh]

I 'm happy to share my new work with Cas12a using kinetics-guided cryoEM to observe R-loop formation and DNA cleavage! Major thanks to @davidwtaylorjr for supporting my first dive into the world of structural biology! 1/n https://t.co/VpJQiCoNcI

[Isabel S @isabel_stroh]

This was a great way to build off of our previous kinetic characterization and help better understand the distinct specificity profiles seen for Cas12a by @ItsOKIDoScience @IlyaFinkelstein... How does Cas12a compare to Cas9? It seems to have a more "hands-off" approach... 2/n