Excited to share the lab's first preprint ! We previously observed CD226+ macrophages in brown fat that resemble CCR2- and IRF4-dependent peritoneal small Macs, but we didn't know anything about them...
https://t.co/z7yaGzKBhL
This novel macrophage population in salivary glands is regulated by ILC-2 derived GM-CSF and arises mostly from MDP-derived monocytes. Importantly, they also express CD226+ and have a lot in common with the population we describe in adipose tissue... More to come !
CSF1R signalling sustains glucose uptake in Ly6Chigh monocytes to fuel the hexosamine biosynthetic pathway (HBP), which in turn allows optimal CSF1R expression. Impairing glucose flux towards HBP through GFPT1 invalidation leads to increased Ly6Chigh/Ly6Clow ratio.
CSF1R regulates monocyte subset differentiation and intracellular metabolism. https://t.co/sq0SU86W1C
Our new preprint is now online ! Here, we explore links between CSF1R signalling, intracellular metabolism and monocyte differentiation.@LP2M_Lab@Cnrs20@Univ_CotedAzur@Inserm
We report that surface CSF1R expression relies on continuous translation and export to the membrane. CSF1R recycling rate accelerates as monocytes differentiate from the Ly6Chigh to the Ly6Clow subset, and CSF1R blockade prevents Ly6Chigh commitment towards this trajectory.
Excited to share the lab's first preprint ! We previously observed CD226+ macrophages in brown fat that resemble CCR2- and IRF4-dependent peritoneal small Macs, but we didn't know anything about them...
https://t.co/z7yaGzKBhL
Excited to share the lab's first preprint ! We previously observed CD226+ macrophages in brown fat that resemble CCR2- and IRF4-dependent peritoneal small Macs, but we didn't know anything about them...
https://t.co/z7yaGzKBhL
We report that this subset is conserved across several tissues and especially fat, in which they regulate lipid metabolism. Importantly, these cells have a rapid turnover from monocytes, and in particular MDP-derived monocytes that are biased to differentiate into CD226+ Macs !
Happy to see our review on macrophages of the vascular system published in Nature Cardiovascular Research !
@GwenRandolph_ @jichang_han @IvanovLab https://t.co/x6xZtbMaMC
🚨preprint alert! Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages (LAMs)
https://t.co/OLtLWf6Ffw
Ivanov lab paper ! Very happy to see our story on monocyte glucose metabolism online in @NatureComms today. Inhibition of Glut1 depletes the majority of blood monocytes, yet atherosclerotic plaques still develop normally🧐 @LP2M_Lab
https://t.co/COd6e7bYxf
Happy to see this story out!
@LP2M_Lab@Univ_CotedAzur@CNRS_DR20@Bastien_Dolfi@AlexGallerand
Sex‐specific impact of psychosocial stress on hematopoiesis and blood leukocytes - Dolfi - European Journal of Immunology - Wiley Online Library https://t.co/GH6WRBQgAs
Glad to share our new study investigating the unknown diversity of adrenal glands macrophages. I would like to thanks all my team and collaborators for this incredible work ! https://t.co/laJagDz3Th
Out in Nat Comms! https://t.co/MyLIGcLDvE
Great work by @AlexGallerand, @MarionAlya, Stoyan and many others.
This one is very special, and I wanted to highlight all the amazing single-cell analysis done by @mfiruleva, allowing me to do more as a senior author for the first time