ixxiar

sasi guzien azpitik eta ore guzien gainetik... denbora bizitzen

[Manuel Ruiz-Pablos @manruipa]

🧬 Farewell to the psychosomatic myth: DecodeME shows that ME/CFS is an organic disease with a genetic footprint

Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a devastating illness that affects millions of people worldwide. Its hallmark symptom, post-exertional malaise (PEM), means that even minor activities can trigger a severe and long-lasting worsening of health.
For decades, one of the big questions has been:

👉 Does ME/CFS have a clear biological basis, or is it just a cluster of unexplained symptoms?

The DecodeME study, carried out in the UK with 15,579 patients and more than 259,909 controls, provides the most compelling answer so far: yes, there is a measurable genetic footprint in this disease.

🔎 What is DecodeME and what does a GWAS mean?
DecodeME is the largest genetic study ever conducted in ME/CFS. It used a GWAS (Genome-Wide Association Study), which compares millions of small DNA variations (SNPs) between patients and healthy individuals.

📍 A GWAS does not look for a single “causative mutation,” but instead highlights regions of the genome that act as “treasure maps” 🗺️ with marks saying “something important could be here.”

📌 Key findings
The DecodeME team identified eight regions of the genome significantly associated with ME/CFS.

▪️Immune system
🔹HLA-DQA1 (chromosome 6, HLA class II)
Highlighted allele: HLA-DQA1*05:01
➖Function: presents fragments of viruses and bacteria to T cells.
➖Relevance: less frequent in ME/CFS patients, suggesting a protective effect.
The HLA-II region is central in autoimmunity, placing ME/CFS in the same “genetic territory” as rheumatoid arthritis or multiple sclerosis.

🔹RABGAP1L (1q25.1)
➖Helps eliminate bacteria such as Streptococcus pyogenes and limits viral replication.
➖Connects with the hypothesis that ME/CFS often follows an infection.

🔹OLFM4 (13q14.3)
➖Regulates neutrophil activity, a key frontline defense.
➖Suggests a disruption in innate immunity.

🔹TRIM38 and BTN2A2 (6p22 and 6p21)
➖Regulate T cell activation and immune tolerance.
➖Reinforce the idea of imbalance in adaptive immunity.

▪️Nervous system and pain
🔹CA10 (17q22): involved in synapse formation and chronic pain circuits.
🔹SUDS3 (12q24.23): regulates microglial activation → neuroinflammation.

▪️Metabolism and inflammation
🔹Variants in 12q24.23 have also been linked in other studies to energy metabolism, inflammation, and cardiovascular risk.

🧩 What does all this mean?
The identified variants mostly affect:
➖Adaptive immunity (HLA-II, T cells, defense against viruses/bacteria).
➖Nervous system (synapses, chronic pain, brain inflammation).
➖Metabolism/energy (inflammatory and energetic balance).

The estimated genetic heritability is ~9.5%: a modest value, similar to migraine, irritable bowel syndrome, or long COVID.

This confirms that ME/CFS arises from the interaction between genetic susceptibility + external triggers(infections, toxins, trauma). In other words, ME/CFS is neither purely genetic nor purely environmental: it emerges from the combination of predisposition + triggers (infections, toxins, physical stress), as already suggested in other studies.

🚨 The most striking result: HLA class II
The HLA-II locus stands out as key.

Although the detected allele appears protective, its presence confirms that adaptive immunity lies at the heart of the disease.

In other autoimmune disorders, other HLA-II alleles confer risk. In ME/CFS, the findings suggest that different alleles may modulate vulnerability in opposite directions.

🔮 A before and after
DecodeME marks a turning point:
✅ For the first time, ME/CFS is placed on the genetic map of human diseases.
✅ The study opens new avenues toward therapies targeting adaptive immunity and neuroinflammation.
✅ Future projects (such as SequenceME and sex chromosome analysis) promise even more answers.

As lead researcher Chris Ponting put it:
“We are providing the X marks on the treasure map. Now we need scientists to start digging.”

Conclusion
ME/CFS is not an inscrutable mystery nor a “wastebasket diagnosis.” DecodeME proves there is a real genetic framework, where the interaction between the immune system, brain, and metabolism seems to be the key.

🔗:https://t.co/wzA1tK9nAT

And I will go one step further: the HLA-II region may hold the central clue. More on this genetic predisposition and our hypothesis coming soon. 👇

https://t.co/QyP1vXuj4o

[charlos @loscharlos]

“EBV was for years dismissed as a mild rite of passage.. But that view has been changing rapidly since a 2022 study provided strong evidence EBV is a trigger for multiple sclerosis.. Researchers also believe EBV plays a role in.. certain cancers.. a hidden driver of #LongCovid”

[ixxiar @ixxiar]

@jonabril Konturatu zera ea puntuka 7 edo 8 bertso kantatu ttuzten?

[TOMaskup @RubberDucky333]

Quite a headline
https://t.co/PbLVRjoZuh

[NotRecovered @Not_Recovered]

Today ist the official launch of the #LetterForLife campaign!

Support the campaign and millions of #LongCovid and #MECFS sufferers by sending a postcard to @SKyriakidesEU and @vestager.

Together for a real #HealthUnion! @EU_Health

https://t.co/6QXob8NYm0

[Hans Collin @HansCollin2]

19/5/23.
Ministerio de Salud de EEUU:
“Las reinfecciones de Covid son dañinas y pueden producir graves secuelas a largo plazo.”

Hay que tener sangre fría para esperar con paciencia a que la OMS señale el dizque “fin de la emergencia” para reconocer esto. https://t.co/vtx4VMPaIQ

[ixxiar @ixxiar]

@HondarribiaUdal Ze pena! 🤮
Askotan bezala, antzerkira joan gara, tarte atsegin bat pasatzeko asmoz. Baina, gogoratzen dudala, ez dut sekula horren antzezlan eta antzezle txarrik ikusi. Ezta amateurrak ere. Hemendik aurrera, zer lan den ondo begiratu beharko da, konfidantza berreskuratu arte.

[🍀LCEUS-Long CoVID Euskal Herria Elkartea @covideuskal]

#EndTheSilence
#LongCovidAwareness

[🍀LCEUS-Long CoVID Euskal Herria Elkartea @covideuskal]

Enferm@s crónic@s de #Covid19 o pacientes de #LongCovid llevan su realidad a la calle "hart@s de ser cuestionad@s por todo lo que hacen y de no tener el respeto que cualquier otr@ enferm@ de otra patología tiene".
@isabelledelez.
#LongCovidAwareness
https://t.co/Qyfs94biGO

[ixxiar @ixxiar]

Persistent viral infections are responsible for some of the most devastating human diseases (...). Now, two research groups have concluded that elevated interleukin-10 (IL-10) production causes the immunosuppression that allows viruses to persist unchecked by the immune system.

[Sass @sasswashere]

Viral persistence: IL-10 is the key | Nature Reviews Microbiology https://t.co/g3eaBNmXto

[ixxiar @ixxiar]

The post-acute sequelae of COVID-19 present major problems for many patients, their physicians and the health-care system. They are unrelated to the severity of the initial infection, are often highly symptomatic and can occur after vaccination. 

CAN OCCUR AFTER VACCINATION

[🍀LCEUS-Long CoVID Euskal Herria Elkartea @covideuskal]

Disfunción autonómica y síndrome de taquicardia ortostática postural (#PoTS) en la #LongCovid. https://t.co/x0QxDVlgJP

[🍀LCEUS-Long CoVID Euskal Herria Elkartea @covideuskal]

¿No te has recuperado desde que te infectaste de #SARSCoV2? ¿No has vuelto a estar como antes de enfermar de #Covid19?

#Covid19 iraupen luzeko gaixotasuna da.
Ez zaude bakarrik!
Hemen gaude⤵️ [email protected] 🍀

[ixxiar @ixxiar]

@eidercarton Hori bai. Nik semaforoa laranjan imajinatu dut.
Ikusiko dugu. Apustua egin beharko dugu 😅😂😂

[ixxiar @ixxiar]

@eidercarton Niri, berriz, ez zait horren txarra iduritu: eskolaren irteeran, bizikletek eta oinezkoek erabateko lehentasuna; kotxeak-eta bigarren mailan. Kostako bideko nahaste-borrastea bainon nabarmen argiagoa.

[Blagan @Blagan_euskaraz]

Adi! Bost egun barru amaitzen da mikroipuinak bidaltzeko epea: urriaren 14ean
Info guztia hemen: https://t.co/b3blEoDbrN

[Hondarribiko Udala @HondarribiaUdal]

Alde Zaharra eta Sabín Arana kalea lotzen dituen igogailua matxuratu egin da, beroak olioa berotu eta motorrean arazoak sortuz. Udala ahalik eta azkarren konpontzeko lanetan ari da, abuztuaren erdialdean gaudela kontutan harturik. Barkatu eragozpenak.

[Lectura disfrutona @Comelibros_69]

¿Qué libro con buena fama se te atragantó?

[Tessa Davis @TessaRDavis]

10 amazing websites that cost you nothing, but will save you hundreds of hours of your life:

[ixxiar @ixxiar]

#WordleEUS #176 4/6

🟨🟨⬜⬜⬜
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🟩🟩🟩🟩🟩

@ElhuyarHizk
Gaurkoan, #ConHrikGabe bat