Elizabeth Smith

Senior Director of Data Science at Arine. AI / ML in Healthcare to improve outcomes and lower costs of care. Previously @UCSF_BCHSI, @UCBIDS @VerisHealth

[Eric Topol @EricTopol]

For medical information, general AI frontier models (Google, OpenAI, Anthropic) outperformed specialized @EvidenceOpen and @UpToDate as assessed by 12 US clinicians, randomized and blinded to which model and extensive testing/benchmarks. This was not anticipated. @NatureMedicine
https://t.co/KCH1ADfQWz

[Bob Wachter @Bob_Wachter]

There are few in this world who were such forces for good as @atulbutte. His dazzling intellect, relentless curiosity, generosity of spirit, boundless charisma, and infinite optimism left a mark on everything he touched and everyone lucky enough to know him. An enormous loss.

[Elizabeth Smith @izzdogg]

yay !!!!!

[Eric Topol @EricTopol]

The largest medical #AI randomized controlled trial yet performed, enrolling >100,000 women undergoing mammography screening, was published today @LancetDigitalH
The use of A.I. led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists without A.I.. https://t.co/GGrLqdG5yq

[Eugenia Shmidt MD @EugeniaShmidtMD]

Do you or someone you know have #IBD and are interested in getting #pregnant soon? Consider participating in WIsDoM, an online-only registry that will help answer how IBD & IBD treatments (including surgery) affect #fertility.

https://t.co/7jEy1SePI1

🙏@nataliesparacio

[Eric Topol @EricTopol]

A small randomized trial of generative #AI for diagnosis again (as seen in a few previous studies) shows higher performance for #AI than physicians + AI. May indicate that physicians need to be trained on how to incorporate AI.
https://t.co/UXpU49PbfA

[Tempus @TempusAI]

We’re excited to share that @CMSGov has granted ADLT status for our xT CDx test. xT CDx is the first FDA-approved #NGS assay to perform matched normal sequence analysis to provide tumor mutation profiling for patients w/ solid organ neoplasms. Learn more: https://t.co/gkOGCkcILh

[UCSF DoC-IT @UCSF_DOCIT]

@UCSF_DOCIT and @UCSFHospitals will develop the first continuous, autonomous monitoring platform for #AI tech in healthcare. Made possible by a $5M donation, this project aims to prevent undetected adverse outcomes for patients. #healthtech #patientcare https://t.co/Et3w2rDkeI

[euan ashley @euanashley]

Exercise may be the single most potent medical intervention ever known. Its benefits in prevention outstrip any known drugs: 50% reduction in the risk of cardiovascular disease, 50% reduction in the risk of many cancers, positive effects on mental health, pulmonary health, GI health, bone health, muscle function. You name it. Exercise helps. In fact, the ability to exercise over long distances was likely key to our evolution as a species because the availability of densely caloric foods due to persistence hunting allowed our energy-avid brains to enlarge. And yet, we have had very little insight into the molecular basis of these magical effects...until now!

Published in yesterday's Nature and featured on the cover was work from our consortium that represents the culmination of a couple of decades of pitching ideas to the NIH, forming a consortium, planning experiments, executing those experiments, and analyzing data at unprecedented scale, all aimed at enhancing our understanding of the molecular transducers of exercise.

It was a major effort from so many in our consortium (playfully named MoTrPAC) and is the first landmark paper of many more to come. This first paper focused on the multi-tissue, multi-omics of treadmill exercise in rats. Specifically, we report the effects of eight weeks of treadmill running on the transcriptome, the epigenome, the proteome, the metabolome, the lipidome and the immunome of a broad range of tissues (in fact, 9,466 assays across 19 tissues, 25 molecular platforms, and 4 training time points).

The result is the most comprehensive molecular map of exercise ever created. At Stanford, my colleague @MWheelerMD and I co-lead the bioinformatics center and it was our team's duty and privilege to ingest the data, QC the data, help analyze the data, and make the data available to the world. Various tools available at our data hub allow you to explore the data, visualize it, and download it for your own use.

Have fun! And stay tuned for human data that will be coming.

So many people to thank who made this possible (see the paper for details). Special shout out to the primary analysts and authors: David Amar, Nicole Gay, & Pierre Jean Baltran.

Paper: https://t.co/0nhXdfhxx0
Data hub: https://t.co/NxTHsVdfRp

[Elizabeth Smith @izzdogg]

@AdanBecerraPhD Ruh roh I love a color-coded spreadsheet 😳

[Eric Topol @EricTopol]

The first randomized trial of medical #AI to show it saves lives
ECG-AI alert in 16,000 hospitalized patients
31% reduction of mortality (absolute 7 per 100 patients) in pre-specified high-risk group
https://t.co/32erebkY1s
@NatureMedicine

[Front Office Sports @FOS]

For the first time in history, the NCAA women's basketball title game drew more viewers than the men's.

[Yann LeCun @ylecun]

IBM & Meta are launching the AI Alliance to advance *open* & reliable AI.
The list of over 50 founding members from industry, government, and academia include AMD, Anyscale, CERN, Hugging Face, the Linux Foundation, NASA....
https://t.co/NdcMb7GMXv

[Elizabeth Smith @izzdogg]

Happy Thanksgiving! Thank you @karpathy

[Andrej Karpathy @karpathy]

New YouTube video: 1hr general-audience introduction to Large Language Models
https://t.co/Bl4WNuNyFJ

Based on a 30min talk I gave recently; It tries to be non-technical intro, covers mental models for LLM inference, training, finetuning, the emerging LLM OS and LLM Security.

[Elizabeth Smith @izzdogg]

@bbabenko ❤️

[Atul Butte @atulbutte]

Currently 80 job openings across the @UofCalifornia @QB3 startup ecosystem! Academia→ discovery→ jobs… let’s keep Bay Area entrepreneurship alive! Start here: https://t.co/5jhTln0U0X.

[Kirti Magudia, MD PhD @KMagudia]

🌟🌟🌟Hiring a postdoc candidate, research scientist or research assistant🌟🌟🌟
(retweets appreciated)

Exciting times!

@KMagudia and @ecalabr are recruiting a candidate to join us here at @DukeRadiology @duke_dair

Apply here: https://t.co/FXNKTB9vjR

[The New York Times @nytimes]

Colon cancer cases are rising among younger adults, according to a study from the American Cancer Society this month. Here's what to know about early signs, screening and prevention. https://t.co/4KQVEF9FeI

[Elizabeth Smith @izzdogg]

@eshaight @UCSFAnesthesia Congratulations!!! :)

[Elizabeth Smith @izzdogg]

@StanfordRadPD Yikes, there are ZERO women ?!?!?!? That’s disappointing, to say the least.

[Bob Wachter @Bob_Wachter]

I can't recall a @UCSF grand rounds that was more fascinating or mind-blowing than this far-ranging discussion of #ChatGPT's implications for healthcare – clinical, research, and education – by @atulbutte, @AaronNeinstein, @SaraMurrayMD & @LowensteinMD. https://t.co/QKRbMi5Uvt