alextcn

founder at Fira (yc w25) - building ai financial research assistant

[Rhys @RhysSullivan]

you ever see the way someone prompts and lose respect for them

[Andrew Rea @andrew__rea]

you should probably not work at a startup or be around startup CEOs if you don't want to get asked about why this isn't happening faster... always, until you die or the company achieves mega-scale.

and even then, we're gonna want it to go faster.

and it almost always can go faster.

[serafim @serafimcloud]

The best products of the 21st century have yet to be shipped.

With 21st, any idea can find its aesthetic and design, even if you aren’t a designer.
Meet the first vibe crafting tool for everyone….

So every product can have soul.

[alextcn @jackqack]

are you @apralky?

[alextcn @jackqack]

Looking forward to this

[Trae Stephens @traestephens]

Peter has been thinking a lot recently about the modern conception of the antichrist.

Some of your joined one of the "Plague Theology" sessions he and I hosted on the topic during COVID.

Some of you listened to his interview with Ross Douthat a couple of months ago (yes, humanity should survive).

Others may have watched his interview with Peter Robinson at Stanford.

Over the next couple of months, he's going to do an in-depth four part lecture series with Acts17 Collective in San Francisco breaking down the theology and what it means for the unfolding of the future. You don't want to miss this.

[alextcn @jackqack]

@Galois_Capital @balajis "To most libertarians power is morally illegitimate, but morality has sadly little influence over the realities of power"

https://t.co/1XWdBborMD

[alextcn @jackqack]

@aditabrm reducto is amazing at parsing complex financial document

[alextcn @jackqack]

@ericvishria @GavinSBaker @zeynep those paying attention realize that chatgpt with search and reasoning in a completely different product category now

[Daniel Dhawan @daniel_dhawan]

Introducing Rork[.]app

• Idea to mobile & web app (React Native)
• Publish & share your web app link in minutes
• Test on your mobile via @expo

Go from idea to App Store, just by chatting.

[François Chollet @fchollet]

Absolutely wild that it's just possible to... will things into existence. Throughout your entire education (0-22 y.o.) you are conditioned to accept the world as-is, and in the following decades you slowly unlearn this conditioning and internalize the fact that you can actually change things. Everything.

[alextcn @jackqack]

Исследование мировых пространств реактивными приборами — Цикловский

[John Pompliano @JohnPompliano]

These photos are only ~100 years apart.

There is no limit to what humans can accomplish.

[alextcn @jackqack]

are we the last of those who have the power, or the first of those to be defenceless?

[maharshi @maharshii]

dude how tf did we take sand and make it into 3nm chips that can do numerical computations billions of times per second, and we use those chips to make machines "learn" !?!?!?

magic does not exist in the real world because this is what real magic is.

[alextcn @jackqack]

@kirillzzy why?

[alextcn @jackqack]

@FAL the way people engage on reddit is incredible

https://t.co/pwNHyO4WK0

[alextcn @jackqack]

this is so sick

riddlemethis made it to the top of /r/StableDiffusion today

@FAL is holding the real-time load perfectly

[Patrick Collison @patrickc]

This morning, Nature published two papers on bridge editing, the new genome engineering technology from @ArcInstitute: https://t.co/IL23V7nYoW, https://t.co/tOE10YZakn. I'm quite excited about its potential!

Since the whole thing is pretty arcane, I fed the blog post (https://t.co/tZZWNRUBdU) to Claude 3.5, and asked it to write an introduction. Below is the rather impressive (unedited) result.

Genome Design: The Bridge to Our Biological Future

I.

Imagine you're trying to edit a document, but instead of a cursor, you have a pair of scissors. You can cut out words you don't like, maybe paste in a few new ones, but precise editing? Forget about it. Now imagine someone hands you a pen. Suddenly, you can write whatever you want, wherever you want. This is the kind of leap we're seeing in the world of genome editing.

For the past few decades, we've been snipping away at genomes with tools like CRISPR, making impressive progress but always constrained by the fundamental nature of our tools: they cut DNA. But what if we could write directly into the genome, inserting whatever we want, wherever we want, without ever making a single cut?

This isn't just a "wouldn't it be nice" daydream anymore. Researchers at the Arc Institute have discovered a new system that does exactly that. They're calling it "bridge recombination," and it might just be the biggest revolution in genetic engineering since CRISPR.

II.

To understand why this is such a big deal, we need to take a quick tour through the history of genetic manipulation.

In the late 1990s, we discovered RNA interference (RNAi). This was our first real taste of programmable biology. We could use short RNA sequences to target and shut down specific genes. It was like having a universal remote control for gene expression. Cool, right?

Then came CRISPR in the early 2010s. Suddenly, we could not just turn genes off, but edit them directly. It was like upgrading from a remote control to a basic text editor. We could cut out bad genes and paste in good ones. But there was always a catch: CRISPR works by cutting DNA, and cells don't always repair those cuts exactly the way we want them to.

Both of these systems were revolutionary, but they shared a common limitation: they were destructive. They worked by breaking things – either the RNA transcripts of genes (in the case of RNAi) or the DNA itself (in the case of CRISPR).

III.

Enter the bridge recombination system.

The researchers at Arc Institute, led by Dr. Patrick Hsu, were poking around in the genomes of bacteria, looking at transposable elements. These are sometimes called "jumping genes" because they can cut themselves out of one part of a genome and paste themselves into another.

They were particularly interested in a group called IS110 elements. These are about as minimalist as you can get while still being functional – just a gene for the enzyme that does the cutting and pasting, plus some mysterious flanking DNA segments.

What they found was surprising. When an IS110 element cuts itself out of a genome, those mysterious flanking segments join up to form an RNA molecule. This RNA folds into two loops, one that binds to the IS110 element itself, and another that binds to the target DNA where the element will insert itself.

This RNA – which they've dubbed "bridge RNA" – is the key to the whole system. It's like a set of instructions, telling the enzyme exactly where to insert the DNA and what DNA to insert.

IV.

Now, you might be thinking, "Okay, that's neat, but how is this different from CRISPR?" The key is in how the insertion happens.

CRISPR works by making a cut in the DNA and then relying on the cell's repair mechanisms to insert the new DNA. It's effective, but it's also a bit like performing surgery with a chainsaw. Sometimes you get exactly what you want, but often you end up with small errors or unwanted insertions or deletions.

The bridge recombination system, on the other hand, doesn't cut the DNA at all. It unzips a small section, inserts the new DNA, and zips it back up again. No broken DNA strands, no relying on error-prone repair mechanisms. It's precise in a way that CRISPR can only dream of.

But the real magic is in the programmability. Remember those two loops in the bridge RNA? They can be programmed to recognize any DNA sequence. This means you can tell the system to insert any piece of DNA into any location in the genome. It's like having a word processor for DNA.

V.

The implications of this are staggering. Here are just a few possibilities:

• Gene Therapy 2.0: Current gene therapy approaches often rely on somewhat random insertion of therapeutic genes. With bridge recombination, we could insert corrective genes exactly where they need to go, without risking disruption of other important genes.
• Synthetic Biology: Want to give an organism a completely new capability? Just design the gene and insert it precisely where you want it.
• Evolutionary Biology: We could insert reporter genes at specific locations across the genome, allowing us to watch evolution happen in real time.
• Agricultural Improvements: We could insert beneficial genes into crops with unprecedented precision, potentially revolutionizing our ability to create drought-resistant or nutrient-enhanced plants.
• Bioengineering: Imagine being able to design and build entire genetic circuits, inserting each component exactly where it needs to be for optimal function.

VI.

In the grand scheme of things, the discovery of bridge recombination feels like a pivotal moment. It's as if we've been trying to write the book of life with a typewriter, and someone just handed us a word processor.

The researchers at Arc Institute have opened a door to a new era of genome design. As with any breakthrough of this magnitude, it's hard to predict exactly where it will lead. But one thing is certain: the future of biology just got a lot more interesting.

As we stand on the brink of this new frontier, I'm reminded of a quote from Arthur C. Clarke: "Any sufficiently advanced technology is indistinguishable from magic." With bridge recombination, we're not just editing the genome anymore. We're writing it. And that, my friends, is pretty close to magic.

[alextcn @jackqack]

besides solving our riddles, you can create your custom game and challenge your friends

like this one: https://t.co/5rY4zSWHJD

[alextcn @jackqack]

We just launched Riddle Me This 🚀

it's an experimental quiz game where players are solving visual riddles. the goal is to match AI generated images as close as you can

made by @molefrog, @dearkafka and me. lightning fast thanks to @fal

[alextcn @jackqack]

play now: https://t.co/VRZkSQi5nl