Online Now: Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations https://t.co/VKDkwPI06D
Grateful for a 5-yr R01 award from the National Institute on Aging for developing vaccines against neurodegenerative diseases. Thanks to collaborations with @JackrelLab and support from @WashUBME@WashUengineers
Interesting: New paper from @JackrelLab & colleagues reports PDZ serine protease HTRA1 disaggregates #Parkinsons-associated ฮฑ-synuclein amyloid fibrils & converts them into non-toxic/seeding incompetent species; Future = small molecule HTRA1 modulators
https://t.co/qRyGyqixCr
๐ขWe are excited to share that our paper on HTRA1 remodeling of alpha-synuclein is available now online with @NatureComms! Check out our main findings below ๐
Big shout out ๐ฃ๏ธ to the team that made it all possible: Sheng Chen, @AnuradhikaP, Braxton Bell, Joey Fritsche, Hector Palacios, Maurie Balch, @MacySprunger, @matthewkhoward, Jeremy Ryan, Jessica Haines, @gjpattij, @GusDavisLab, & Meredith Jackrel!
Yesterday Sheng (Andy) Chen defended his dissertation like a star โญ๏ธ We are proud of all he has accomplished during his graduate studies! Congrats Dr. Chen!
Yesterday we celebrated @MacySprunger's dissertation defense! ๐She is the first graduate student to defend from the lab and we are very proud of all she has accomplished during her graduate studies!๐งฌ
It is the first look at one of our big projects in the lab! We have been investigating how human serine protease HTRA1 can prevent and disaggregate alpha-synuclein amyloid! You can check out the preprint now ๐๐https://t.co/HoM4ugaSTP