Jagged Frontier

On the AI frontier. New models. New capabilities. New ground.

[Jagged Frontier @jaggedfrontier]

DNA is a massive uncharted yet at the center of every living being but no one has the time and capabilities to keep investigating it and that seems the natural strength of AI , i hope all the AI labs to focus on it this will change medicine and offer a more individual treatments .

[Anthropic @AnthropicAI]

Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.

We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.

Read more: https://t.co/RuEosScSMb

[Jagged Frontier @jaggedfrontier]

@elonmusk That doesn't mean it is a good one .

[Jagged Frontier @jaggedfrontier]

@WhaleInsider They will need to buy a lot more , in fact they need to keep that printing machine running and still won't be enough to cover the gov spending let alone paying the debt .

[Jagged Frontier @jaggedfrontier]

@BullTheoryio It is business as usual but this time the manipulation is more obvious that is all .

[Jagged Frontier @jaggedfrontier]

@cryptorover A huge number that i can't even read at a glance and it is nothing more than a unnoticed fraction of the debt this can't be sustained

[Jagged Frontier @jaggedfrontier]

@Barchart is it just me or is this is starting to get serious .
so what can they do about it since oil and shipping still up ?

[Jagged Frontier @jaggedfrontier]

@nvidia @GoogleDeepMind @emblebi I am all for the AI push in biomedicine i think it is more important than what people assume i hope it will be the next focus after all of that math solving drama .

[Jagged Frontier @jaggedfrontier]

AI is taking over the biomedicine scene is a good thing this is a domain that needs a lot of data handling and we as humans can do it fast enough .

[NVIDIA @nvidia]

With @GoogleDeepMind, @emblebi, and research partners, we’re making AI-predicted protein complex structures for 2,800+ viruses openly available.

This gives scientists a head start in preparing for potential outbreaks.

[Jagged Frontier @jaggedfrontier]

@elonmusk It shows how stupid this is we replaced railroads with highways and paid more for it ?????
humanity is doomed it follows the intrest of the big corps

[Jagged Frontier @jaggedfrontier]

from weak to superhuman in a matter of a few years :

This is what Dario believe will happen to AI in biomedicine like what happened with math , but unlike the pure theoretical nature of math this will have direct effects on us , so be prepared to hear about the gene manipulations from here on and the cure of all diseases potentially .

[Dario Amodei @DarioAmodei]

Today we announced the Claude-led discovery of a molecular machine that we suspect could represent a new gene editing mechanism. Its precise function, biotechnological utility (if any), or level of significance is not yet clear, but at minimum it is work I would have been proud to do as a PhD student. The work was done mostly, though not entirely, by Claude: our life sciences team suggested a broad area of research, Claude read through the literature and a bunch of genome data and discovered something interesting, then Claude proposed experiments to verify the discovery and our team carried them out.

It’s easy to dismiss this as a one-off or curiosity, but we’ve repeatedly seen a pattern where AI performance in new intellectual domains goes from weak to superhuman in a matter of a few years. In 2023 models struggled to do math at the level of an average high-school student. In 2024 they started to do well on math competitions for the best high-schoolers in the country, in 2025 they started to solve minor open problems, in early 2026 more significant open problems, and in late 2026 they are beginning to solve the top few open problems in all of mathematics. We believe AI for biology is on a similar exponential trend.

The main difference between biology and mathematics, of course, is that math can be done purely theoretically, while biology requires experimentation. Some have used this to draw the conclusion that AI’s utility in biology will be limited. We think this is wrong. As we’ve demonstrated today, humans can collaborate with AI to perform the experiments, validate key results in a few weeks and, if necessary, work with the AI to iterate on what they find. Eventually it may even be possible for Claude itself to safely perform the experiments by autonomously controlling lab equipment, with appropriate safeguards in place, but we aren’t doing that today (our lab is also a BSL1/BSL2 facility that doesn't handle materials dangerous to humans).

More broadly, biomedical advancement has many stages — from fundamental biology discoveries, to translational research, to drug discovery, clinical trials, and finally the actual delivery of medicines and health care to patients. We are also interested in these later stages, but even simply accelerating the first stage of fundamental biological discoveries has the potential to speed up and broaden the entire pipeline. Improving our understanding of biology and sharpening biologists’ tools can drive forward all of the later stages, for example by identifying new drug targets, finding new therapeutic modalities, allowing for more precise measurement, and speeding up the experimental loop which itself further accelerates our understanding of biology. This will not in itself speed up clinical trial times, but if it succeeds it could greatly increase the number of promising candidates that go into the pipeline — an increase in throughput even though latency remains.

In Machines of Loving Grace, I wrote about AI’s potential to “cure most diseases in 5-10 years” — a goal that sounds impossible, but one I believe is just barely possible if AI is applied to every stage of the pipeline. The first step is showing that AI can first help with, and then drive, biological discoveries.

Claude’s discovery is the latest in a line of related prior work that goes back decades, beginning with systems like CRISPR, and continuing with discoveries like the bridge recombinase and VIPR in the past few years. Recently, there has been heightened interest in systems based on reverse transcriptase (RT) enzymes, the enzyme underlying the system Claude identified. And most recently, a Stanford team working independently described a novel RT system with an associated non-coding array that is in some ways similar to the one Claude found, though they are distinct systems that evolved independently from each other. I believe that we’re at the very beginning of finding such systems and developing them into powerful tools for biotechnology.

I’m proud of the resources Anthropic has invested in accelerating the public benefits of AI through the life sciences, and we’re aiming both to grow our life sciences team and to work with other scientists to extend this approach to a broad range of problems. If you have a proposal for a research collaboration or are interested in joining our life sciences team, please reach out.

[Jagged Frontier @jaggedfrontier]

@cryptorover I won't believe it until i see it, they just keep manipulating the market to establish full control .

[Jagged Frontier @jaggedfrontier]

@Barchart It is a better investment that stocks at this point .

[Jagged Frontier @jaggedfrontier]

@ClaudeDevs Right after calling for a slow down, was this intended ?

[Jagged Frontier @jaggedfrontier]

@WatcherGuru Free marketing right here

[Jagged Frontier @jaggedfrontier]

@OpenAI Honestly AI voice is the way forward no one has the time to keep typing .

[Jagged Frontier @jaggedfrontier]

@OpenAI While AI can act as a supporting existence which helps in mental health the big issue is it is also an enabler so how did you tackle that ?

[Jagged Frontier @jaggedfrontier]

@AnthropicAI Finally some medicine related AI news please don't just focus on math and forget everything else .

[Jagged Frontier @jaggedfrontier]

@cryptorover What does it mean ?

[Jagged Frontier @jaggedfrontier]

@BullTheoryio The casual great bet by Mr president as usual

[Jagged Frontier @jaggedfrontier]

@StockSavvyShay Where will they get the money from is it more debt or the ipo ?