Samarth Jajoo

making therapeutics

[Samarth Jajoo @jajoosam]

A little bit about what I have been working on :)

[Soham Sankaran @sohamsankaran]

I never met my grandfather.

He died of pancreatic cancer when my father was just 19. Today, Yash Bindal, 33, father to 18-month-old Maya, faces the same fate.

@PopVaxIndia is using AI to make him a personalized generative medicine to extend his life.

https://t.co/O5VIXbmMGd

[Samarth Jajoo @jajoosam]

Hey Melissa! I have POTS symptoms, and have confirmed hypometabolism in the brainstem seen on PET/CT.

I’ve started thiamine after seeing your tweets and reading the Lonsdale book — curious about Dextrose! How does this help? Would be amazing if you could point me to some relevant reading

[Samarth Jajoo @jajoosam]

This has been an incredibly frustrating experience, but on the bright side, it is hard to imagine better training for being a therapeutics developer than to be dealing with a condition that desperately needs a therapeutic.

n=1 trials may be coming your way!

[Samarth Jajoo @jajoosam]

Can anyone introduce me to clinicians who are treating long COVID, or people who have recovered from it?

I've been dealing with difficult Long COVID symptoms for 3 months now, and have had to go on medical leave from work.

Any help would be amazing :)

[Zhidian Zhang @ZhidianZ]

Excited to share this work with @yoakiyama @ChoYehlin @jajoosam @sokrypton
We find that protein language models trained solely on individual protein sequences, implicitly learn the interface contacts of homo-oligomeric assemblies! As the model scales up, more interface signals pop up.

However, we also notice some proteins PDB database marked as homo-oligomers are missing these interface signals. This took us on the journey to investigate the emergence and absence of homo-oligomeric contacts in pLMs.

https://t.co/sdxQTFgDBx

[Samarth Jajoo @jajoosam]

If you live long enough, cancer will come for you too. But if you know soon enough, you can almost certainly do something about it.

We must test early and often. Hiya writes a deeply personal account:

[Hiya Jain @jainhiya_]

In the essay I never thought I would write, I talk about my experience peaking at the "bad side" of medicine and present a defense for blood based early detection (3/3)
Link: https://t.co/GAnwqBJESX

[Alex Kesin @alexkesin]

This morning, one of my closest friends called me sounding concerned. His doctor had informed him that he had a fatty liver. A decade ago that might have been scary news; but today I was able to reassure him that it's something we can easily reverse with medication.

Hearing the tension melt from his voice made me genuinely happy. And it only reinforces my belief that the fruits of the pharma industry really are a gift from God, especially when they touch the lives of people we care about.

[Samarth Jajoo @jajoosam]

@nileshtrivedi Any reason to expect costs to drop? Is there a patent cliff?

[Samarth Jajoo @jajoosam]

If you work on biology, and are excited to bring your therapeutics ideas to patients, seriously consider moving (back!) to India and joining me at @PopVaxIndia. DM / email (samarth [at] popvax . com)

[Samarth Jajoo @jajoosam]

I graduated from Berkeley in May, and have moved back to India to help build a new pharma company.

Exciting therapeutics will be coming out of Hyderabad in the next few years. Here's part of update I wrote up for friends:

https://t.co/dR8cnnrt1V

[Samarth Jajoo @jajoosam]

We desperately need next generation therapeutics for TB.

It should be easier to make better molecules than to wait for the “global south” to get richer.

[Hiya Jain @jainhiya_]

Tuberculosis, for most of human history, has infected and killed millions of people every year.

Despite having *completely curative* therapeutics, we continue to count over a million deaths each year, mostly in low and middle income countries.

Why?

[Samarth Jajoo @jajoosam]

Perhaps this is not as true for CS anymore — but most cutting edge technology is very very hard to build from scratch at home. I definitely wouldn’t be doing biology today if I didn’t go to college!

[Samarth Jajoo @jajoosam]

Beyond finding my best friends, college was an incredible experience because of being able to do research.

Going to a good research university as an undergrad by itself would have made college worth it for me

[Paul Graham @paulg]

Don't drop out of college to start or work for a startup. There will be other (and probably better) startup opportunities, but you can't get your college years back.

[Samarth Jajoo @jajoosam]

Maybe the best (public) robot product demo I’ve seen.

So rare to see people actually building a product here, cannot wait to buy this

[Aaron Tan @aaronistan]

Introducing Lume, the robotic lamp.

The first robot designed to fit naturally into your home and help with chores, starting with laundry folding.

If you’re looking for help and want to avoid the privacy and safety concerns of humanoids in your home, pre-order now.

[Sergey Ovchinnikov @sokrypton]

@joe_fenrir @IanAndersonLOL In the long run, I think VCs should encourage sharing, and taking advantage of "replica exchange". Where academia (high temp chain) is where folks try crazy ideas (rfdiffusion, bindcraft, etc), that are further optimized by industry (low temp chain) with far more resources. (2/2)

[Soham Sankaran @sohamsankaran]

My brother @sahajsankaran & I are pleased to present our new comedy series ‘Ungli’, in which two broke brothers discover India's Electoral Bonds scheme, and hatch a brilliant plan – starting a fake political party to launder money from abroad. (video below)

[Samarth Jajoo @jajoosam]

Build an open source pipette which is motor controlled, has a few customizable buttons, and a great API. Maybe even make a single one unified across p2-1000.

Would save real time if it existed, and is a pre requisite to any real lab automation.

[Niko McCarty. @NikoMcCarty]

What is a specific problem in biology that would be useful to solve, and could be solved for ~$10,000?

[Sergey Ovchinnikov @sokrypton]

CASP is getting cut by NIH... 😢

(Anyone with extra funds wanna help support perhaps the most important competition of the century?)
https://t.co/mOuROZYJLh

[Henry Ko @henryHM_ko]

I wrote a new blog on TPUs -- it's been fun seeing how different they are from GPUs and also drawing things on excalidraw again✏️

https://t.co/kEZXbB8vmX

[Samarth Jajoo @jajoosam]

@HemanthBharatha is it because of prettier interface