James Pollard

Dubs fan, Gym Rat, semi-pro athlete, and animal lover.

[Juanita Broaddrick @atensnut]

This had me laughing so hard I was crying.

These guys are awesome.

[Massimo @Rainmaker1973]

Psilocybin made human cells live 50% longer.

A new study has uncovered surprising anti-aging potential in psilocin—the active metabolite produced when the body breaks down psilocybin, the psychoactive compound found in magic mushrooms.

In laboratory experiments, researchers exposed two human cell lines (skin fibroblasts and fetal lung fibroblasts) to a 100 μM concentration of psilocin. The results were striking: lung cells took 57% longer to reach replicative senescence (the point at which cells permanently stop dividing and accumulate damage), while skin fibroblasts extended their replicative lifespan by 51%.

These findings suggest psilocin may slow fundamental cellular aging processes, possibly by lowering oxidative stress, enhancing DNA-repair pathways, supporting mitochondrial health, or dampening chronic inflammation—mechanisms that overlap with those targeted by leading experimental longevity drugs.

The benefits extended beyond cell culture. In aged female mice (19 months old at the start, equivalent to approximately 60–65 human years), a single monthly dose of psilocybin dramatically improved outcomes. After 10 months of treatment, 80% of the psilocybin-treated animals remained alive, compared with only 50% of untreated controls. Treated mice also displayed markedly fewer visible signs of aging, including reduced fur loss and graying.

This research marks the first direct demonstration that psilocybin/psilocin can influence biological aging itself, rather than solely producing psychological effects. The authors emphasize that the study used relatively conservative dosing and are now advocating for follow-up work with higher or more frequent administration, detailed assessments of immune, metabolic, and cognitive function, and investigations into whether the extended lifespan corresponds to genuine improvements in healthspan and quality of life.

["Psilocybin treatment extends cellular lifespan and improves survival of aged mice." npj Aging, 2025]

[Iris Seraphina  @iris_seraphina]

It’s “Bring Anything But Your Backpack” to school day 🎒

[T. Bernadetti @MrsRoyKeaneo]

Oh fuck!

I'm cryin! 😂😂😂😂😂
"Man's laughter"

Turn it up!

[James Pollard @jamespollard8]

@rinadalanakrih lol this is how we met

[James Pollard @jamespollard8]

@dickiebush My take on #2:
1. It’s rude
2. I want to be squeezed into a plane for the shortest amount of time possible so I like to board last. The only exception is if all the overhead bin space will likely fill up.

[James Pollard @jamespollard8]

@Kris10Pojunis @JacobGleim @Matt_B_Nelson 🔥

[Ryan Delk @delk]

I’m not sure an interview has ever altered my (uninformed) opinion of another human so profoundly.

[James Pollard @jamespollard8]

For those who haven’t seen this yet, it’s SO FUNNY. I love this. https://t.co/ESt2kEdGOo

[Massimo @Rainmaker1973]

Probably one of the most 'alien-like' species, the ribbon worm spits a living, tree-like proboscis to hunt it prey

[read more: https://t.co/ForVQbFfbY]
[📹 https://t.co/yE6Sa2sz64]

[James Pollard @jamespollard8]

Do you remember when you joined Twitter? I do! #MyTwitterAnniversary

[James Pollard @jamespollard8]

Here’s a separate train of thought but I LOVE this: https://t.co/9tloRMDepw

[James Pollard @jamespollard8]

@Liface I’m starting to brainstorm a blogpost about why we should set the bar higher as far as what we expect from ourselves as being someone’s close friend. I’m curious to hear a couple of your initial thoughts. Some of mine:

[James Pollard @jamespollard8]

An obvious caveat here is that our ability to do these things depends greatly on how we’re personally doing and what capacity we have. (Although I’m optimistic that much of the time we help others is actually capacity-boosting for ourselves.)