JamshidiLab

Systems Medicine through: Systems Biology, Mathematical Modeling/Simulation, and Minimally-invasive, Image-guided Interventions, UCLA. Tweets are my own.

[JamshidiLab @JamshidiLab]

Excited to share results from our analysis of pediatric fatty liver disease, #NAFLD, using multi-dimensional data integration https://t.co/NtlnpnEpFU #liver disease, #uclaradiology #systemsbiology @UCLAHealth @UCSanDiego @MDPIOpenAccess @UCSDHealth @RadiologyUcla

[Stephen Diehl @smdiehl]

A 14-line Python script using gzip outperforming a 345m parameter transformer model is probably the most hilarious result I've seen all year.
https://t.co/E7o9gFNA6u

[Nature Reviews Drug Discovery @NatRevDrugDisc]

FDA approves first cell therapy for type 1 diabetes https://t.co/tvkOnOEUBK

[Veera Rajagopal  @doctorveera]

A mind-blowing paper has come out today in @Nature

In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).

Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.

The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.

When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.

The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.

The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:

“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)

https://t.co/zA9OAqSoAu

[Paul Wischmeyer MD @Paul_Wischmeyer]

🙋‍♂️ 41 yo in the hospital 🏥 for 20 days with sickle cell pain crisis.

What’s the diagnosis?
#MedEd #MedTwitter #FOAMcc

[Martin Picard @MitoPsychoBio]

All normal mammalian cells behave as part of a cell collective. Like whole animals, cells survive and thrive by interacting with each other

https://t.co/CL1TwDyyeh

[Human Protein Atlas @ProteinAtlas]

Version 23 of the Human Protein Atlas is released including an updated genome assembly, a new Interaction section with data for human protein-protein interaction networks, and lots of other updates.

Read more
https://t.co/zHLwm2muUd

[Fermat's Library @fermatslibrary]

A Proof withouth words

(a+b)² =a² + 2ab + b²

⬛️

[Gabriel Peyré @gabrielpeyre]

The primary visual cortex is organised as an oriented wavelet transform. Huber and Wiesel got the Nobel prize for this discovery. Mapping the orientation on the surface of the cortex creates singularities called pinwheells. https://t.co/D5nCcRPmFX https://t.co/j45tCL6JRg

[Niko McCarty. @NikoMcCarty]

ATP synthase spins 130 times/s.

That's 4x faster than a piston airplane's propeller.

How do we know this? A beautiful experiment:

A long protein, with a bead at one end, was fused to part of ATP synthase. A camera tracked the bead as it whipped 'round.
https://t.co/95yuqwmo6i

[Martin Bauer @martinmbauer]

You know Pythagoras theorem?

It holds only on a flat surface. On a curved surface -like earth- a right triangle can even have triangles with 3 right angles

Can we generalise Pythagoras? Yes, and the generalisation is a beautiful equation relating triangles and circles

🧵 1/6

[JVIR @JVIRmedia]

The Effect of Smoking Cessation on the Technical Success of Endovascular Treatment for Thromboangiitis Obliterans

https://t.co/yOj8Ctxy3P

Fig: Angiography of 41 y/o M with severe claudication (R3) diagnosed with thromboangiitis obliterans 10 years beforehand

[Cliff Pickover @pickover]

Mathematics, physics, reality.

This is an example of a form of humor that requires so much knowledge that it is understandable by very few humans. https://t.co/Sccbn86Ptc

[Cliff Pickover @pickover]

Physics, mathematics, the universe.

You've heard of velocity and acceleration, but have you heard of.... https://t.co/HgA3MYro22

[Science Magazine @ScienceMagazine]

Hibernating brown bears rarely suffer from blood clots despite 6 months of immobilization.

A new Science study has revealed a factor that appears to protect the animals against this immobility-associated thrombosis. Learn more: https://t.co/Q3KtL9Fxbf, https://t.co/CHA0AlSdue

[Massimo @Rainmaker1973]

Quantum levitation and quantum locking are a consequence of the Meissner effect and allow superconductor to glide freely over a track of magnets

[read more: https://t.co/vIkRKs9uEx]
[📹 magneteasy1: https://t.co/nXBD2A4Giu]
https://t.co/YzodoapMaD

[Samuel Bakhoum @Samuel_Bakhoum]

Very intriguing paper in ⁦@CellChemBiol⁩ showing the #Cancer cell-autonomous role of #cGAS_STING in promoting drug resistance through nfkb. Yes therapy activates #STING but that’s not always a good thing. The adaptive response can help tumor cells https://t.co/v88FgeGiF3

[Science Magazine @ScienceMagazine]

A new #SciencePerspectives looks at the current approaches and challenges facing regenerative medicine. https://t.co/yRpZCGLKXH